The aging kidney: increased susceptibility to nephrotoxicity

Wang, Xinhui; Bonventre, Joseph; Parrish, Alan

doi:10.3390/ijms150915358

Cited by 132Acute Kidney Injury ResearchChemotherapy-induced organ toxicity mitigationChronic Kidney Disease and Diabetes

The aging kidney: increased susceptibility to nephrotoxicity

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Wang, Xinhui, Bonventre, Joseph, Parrish, Alan·2014·International Journal of Molecular Sciences

DOI 10.3390/ijms150915358PMC PMC4200815

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Abstract

Three decades have passed since a series of studies indicated that the aging kidney was characterized by increased susceptibility to nephrotoxic injury. Data from these experimental models is strengthened by clinical data demonstrating that the aging population has an increased incidence and severity of acute kidney injury (AKI). Since then a number of studies have focused on age-dependent alterations in pathways that predispose the kidney to acute insult. This review will focus on the mechanisms that are altered by aging in the kidney that may increase susceptibility to injury, including hemodynamics, oxidative stress, apoptosis, autophagy, inflammation and decreased repair.

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The aging kidney has increased sensitivity to stress and PCD.
“For example, the aging kidney has increased sensitivity to stress and PCD, and rodent models show decreased levels of Bcl-2, and increases in Bax, cytochrome c and caspase-3 (Wang et al., 2014).”
From Programmed cell death in aging (2015) · cites this paper as Wang et al., 2014

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Authors: Wang, X., Bonventre, J., & Parrish, A.
Affiliations: University of Missouri (US)
Brigham and Women's Hospital (US)
Corresponding author: Parrish, Alan
ORCID: Wang, Xinhui
Bonventre, Joseph
Parrish, Alan
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2014-09-01
Volume: 15
Issue: 9
Pages: 15358-15376
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms150915358
PMC: PMC4200815
OpenAlex: W2124242901
Cited by: 132
References: 147
Citations by year: 2026: 5 · 2025: 9 · 2024: 9 · 2023: 13 · 2022: 13 · 2021: 10 · 2020: 11 · 2019: 8 · 2018: 12 · 2017: 13 · 2016: 15 · 2015: 14
FWCI: 2.05
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institute on Aging (R01AG034154)
National Institute of Diabetes and Digestive and Kidney Diseases (R37DK039773, R37-DK39773, R01DK072381)
Topics: Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
Health Sciences › Medicine › Pathology and Forensic Medicine › Chemotherapy-induced organ toxicity mitigation
Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
Keywords: kidney aging, nephrotoxicity, acute kidney injury, renal hemodynamics, oxidative stress, apoptosis, autophagy, renal inflammation, kidney repair
MeSH terms: Aged, Aging, Animals, Cardiovascular Diseases, Diabetic Nephropathies, Disease Susceptibility, Hemodynamics, Humans, Inflammation, Ischemia, Kidney, Kidney Failure, Chronic, Mice, Inbred C57BL, Middle Aged, Pharmacokinetics, Prognosis, Rats, Inbred F344, Regeneration, Xenobiotics, Reperfusion Injury, Comorbidity, Cell Death, Age of Onset, Oxidative Stress, Mice, Rats, Acute Kidney Injury

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The aging kidney: increased susceptibility to nephrotoxicity

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