The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The Aging Kidney: Physiological Changes
Open accessAbstract
Age-associated loss of kidney function has been recognized for decades. With aging, many subjects exhibit progressive decreases in glomerular filtration rate (GFR) and renal blood flow (RBF), with wide variability among individuals. The fall in GFR is due to reductions in the glomerular capillary plasma flow rate, and the glomerular capillary ultrafiltration coefficient. In addition, a primary reduction in afferent arteriolar resistance is associated with an increase in glomerular capillary hydraulic pressure. These hemodynamic changes occur in concert with structural changes, including loss of renal mass; hyalinization of afferent arterioles and in some cases, development of aglomerular arterioles; an increase in the percentage of sclerotic glomeruli; and tubulointerstitial fibrosis. Aging is associated with altered activity and responsiveness to vasoactive stimuli, such that responses to vasoconstrictor stimuli are enhanced, while vasodilatory responses are impaired. Changes in the activity of the renin-angiotensin and nitric oxide systems appear to be particularly important, as is the modulating effect of gender. These changes may predispose the older kidney to acute kidney injury, including normotensive ischemic nephropathy, as well as progressive chronic kidney disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Prevalence of Chronic Kidney Disease in the United States
Coresh, J., Selvin, E., Stevens, L. A., Manzi, J., Kusek, J. W., Eggers, P., Van Lente, F., & Levey, A. S. (2007) · JAMA · doi:10.1001/jama.298.17.2038 · Cited by 4,895
Predictors of New-Onset Kidney Disease in a Community-Based Population
Fox, C. S. (2004) · JAMA · doi:10.1001/jama.291.7.844 · Cited by 1,241 · cited 1×
“Epidemiologic studies suggest that acceleration of age-related loss of renal function may be associated with systemic hypertension (7,8), lead exposure (9), smoking (8,10), dyslipidemia (8), atherosclerotic disease (10), presence of inflammatory markers (11,12), increased levels of advanced glycosylation endproducts (…”
BackgroundEffects of renin–angiotensin system blockade in the aging kidney
Ferder, L. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00264-4 · Cited by 52
Cited by
Levey, A. S., & Coresh, J. (2012) · The Lancet · doi:10.1016/s0140-6736(11)60178-5 · Cited by 1,841
Molecular mechanisms of renal aging
Schmitt, R., & Melk, A. (2017) · Kidney International · doi:10.1016/j.kint.2017.02.036 · Cited by 235
The aging kidney: increased susceptibility to nephrotoxicity
Wang, X., Bonventre, J., & Parrish, A. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150915358 · Cited by 132
Tondo, L., Abramowicz, M., Alda, M., Bauer, M., Bocchetta, A., Bolzani, L., Calkin, C. V., Chillotti, C., Hidalgo-Mazzei, D., Manchia, M., et al. (2017) · International Journal of Bipolar Disorders · doi:10.1186/s40345-017-0096-2 · Cited by 125
The renin-angiotensin system and aging in the kidney
Yoon, H. E., & Choi, B. S. (2014) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2014.29.3.291 · Cited by 95
Castro, V. M., Roberson, A. M., McCoy, T. H., Wiste, A., Cagan, A., Smoller, J. W., Rosenbaum, J. F., Ostacher, M., & Perlis, R. H. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.254 · Cited by 90
Changes in glomerular parietal epithelial cells in mouse kidneys with advanced age
Roeder, S. S., Stefanska, A., Eng, D. G., Kaverina, N., Sunseri, M. W., McNicholas, B. A., Rabinovitch, P., Engel, F. B., Daniel, C., Amann, K., et al. (2015) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00144.2015 · Cited by 62
Stover, J. F., Belli, A., Boret, H., Bulters, D., Sahuquillo, J., Schmutzhard, E., Zavala, E., Ungerstedt, U., Schinzel, R., Tegtmeier, F., et al. (2014) · Journal of Neurotrauma · doi:10.1089/neu.2014.3344 · Cited by 53
Schoretsanitis, G., Spina, E., Hiemke, C., & de Leon, J. (2018) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2018.1549489 · Cited by 50
Half-lives of several polyfluoroalkyl substances (PFAS) in cattle serum and tissues
Drew, R., Hagen, T. G., Champness, D., & Sellier, A. (2022) · Food Additives & Contaminants: Part A · doi:10.1080/19440049.2021.1991004 · Cited by 42
Rej, S., Elie, D., Mucsi, I., Looper, K. J., & Segal, M. (2015) · Drugs & Aging · doi:10.1007/s40266-014-0234-9 · Cited by 31
Need for Nutritious Convenience Foods for the Elderly Population: A Review
Agarwal, V., & Joshi, I. (2021) · Current Nutrition & Food Science · doi:10.2174/1573401316999201009144719 · Cited by 3
Kaplan, A., Ceylan, B., Baydil, B., & Šimenko, J. (2025) · Applied Sciences · doi:10.3390/app151910304
Metadata
- Authors
- Weinstein, J. R., & Anderson, S.
- Venue
- Advances in Chronic Kidney Disease
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 17
- Issue
- 4
- Pages
- 302-307
- ISSN
- 1548-5595 (ISSN-L)
- OpenAlex
- W2140577591
- Cited by
- 639
- References
- 3
- FWCI
- 10.15
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
