Half-lives of several polyfluoroalkyl substances (PFAS) in cattle serum and tissues

Drew, Roger; Hagen, Tarah G.; Champness, David; Sellier, Amelie

doi:10.1080/19440049.2021.1991004

Cited by 42Per- and polyfluoroalkyl substances researchToxic Organic Pollutants ImpactSynthesis and properties of polymers

Half-lives of several polyfluoroalkyl substances (PFAS) in cattle serum and tissues

Drew, Roger, Hagen, Tarah G., Champness, David, Sellier, Amelie·2022·Food Additives & Contaminants: Part A

DOI 10.1080/19440049.2021.1991004

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Abstract

Roger Drewa**, Tarah G. Hagena#, David Champnessb & Amelie Sellierca ToxConsult Pty Ltd, Malvern East, Australiab Department of Economic Development, Jobs, Transport and Resources (now known as the Department of Jobs, Precincts and Regions), Agriculture Victoria, Hamilton, Australiac Wellington – Laboratory, AsureQuality, Auckland, New ZealandCONTACT Roger Drew rogerdrew@bigpond.com Drew Toxicology Consulting, Malvern East, Victoria 3145, Australia* Present affiliation: Drew Toxicology Consulting, Malvern East, Victoria, Australia. Adjunct Associate Professor, Department of Epidemiology and Preventive Medicine, Monash University, Victoria, Australia# Present affiliation: SLR Consulting Australia Pty Ltd, East Melbourne, Victoria, Australia.ABSTRACTCattle that were at steady-state serum polyfluoroalkyl substances (PFAS) concentrations due to several years of exposure to water contaminated by residues of Aqueous Film-Forming (AFFF) firefighting foam had perfluorooctane sulphonate (PFOS) isomers, perfluoroheptane sulphonate (PFHpS), perfluorohexane sulphonate (PFHxS), perfluorononanoic acid (PFNA) and perfluorodecanoic acid (PFDA) in serum. Elimination serum half-lives were determined in five heifers from serial blood sampling over 215 days. Eleven additional animals that had blood sampled on day 19 (d19) were euthanised on d63. PFAS half-life estimates from the serial blood sampling and from d19/d63 data were not significantly different. The combined (n = 16) serum half-lives (in days) were: total PFOS (tPFOS, 74.1 ± 13.4), PFHpS (45.7 ± 9.4), PFHxS (9.3 ± 1.3), PFNA (12.3 ± 3.2) and PFDA (60.4 ± 10.4). The half-lives of linear PFOS (L-PFOS, 69.4 ± 11.6) and mono branched PFOS isomers (m-PFOS, 83.6 ± 19) were not significantly different from tPFOS, but for the di-branched isomers (di-PFOS), the serum half-life was significantly lower (29.9 ± 5.8). Animal age (1.4–12.3 years old) and serum concentration at the start of depuration did not influence half-lives, and there was no difference between steers and heifers. Consideration of serum and tissue PFAS concentrations at d63 and d215 indicated there was no difference in tPFOS depuration from serum or muscle, but elimination from liver and kidney may be slightly longer. Depuration of PFHpS is essentially the same in serum, kidney and liver, and it is expected depletion from muscle would be comparable. The short half-life of di-PFOS, PFHxS and PFNA did not allow an assessment of clearance from tissues because they were not measurable at d215 but based on the results for PFOS and PFHpS, elimination of PFHxS from tissues is expected to mirror that from serum. Human health risk assessment implications are discussed.

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Knowledge of the various mechanisms of PFAS toxicokinetics in humans, such as absorption, distribution, metabolism and excretion, is still limited, as most available studies have been carried out in animals and have shown high interspecies differences in absorption and elimination pathways.
“Knowledge of the various mechanisms of PFAS toxicokinetics in humans, such as absorption, distribution, metabolism and excretion is still limited, as most available studies have been carried out in animals and have shown high interspecies differences in absorption and elimination pathways (Chou and Lin, 2019; Pizzurro et al., 2019; Drew et al., 2022).”
From Estimation of per- and polyfluoroalkyl substances (PFAS) half-lives in human studies: a systematic review and meta-analysis (2024) · cites this paper as Drew et al., 2022

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Authors: Drew, R., Hagen, T. G., Champness, D., & Sellier, A.
Affiliations: Fujirebio US (United States) (US)
Agriculture Victoria (AU)
Wellington – Laboratory, AsureQuality, Auckland, New Zealand
Corresponding author: Drew, Roger
Venue: Food Additives & Contaminants: Part A
Publisher: Informa UK Limited
Published: 2021-11-03
Volume: 39
Issue: 2
Pages: 320-340
ISSN: 1944-0049 (ISSN-L)
1944-0057
DOI: 10.1080/19440049.2021.1991004
OpenAlex: W3208861935
Cited by: 42
References: 83
Citations by year: 2026: 7 · 2025: 14 · 2024: 11 · 2023: 6 · 2022: 4
FWCI: 1.98
Type: journal article
Language: en
Open access: closed
Locations: Food Additives & Contaminants Part A (publishedVersion)
PubMed (publishedVersion)
Funders: no funding associated with the work
Topics: Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Physical Sciences › Materials Science › Polymers and Plastics › Synthesis and properties of polymers
Keywords: polyfluoroalkyl substances, PFAS, serum half-life, cattle, heifers, PFOS isomers, PFHpS, PFHxS, PFNA, perfluorodecanoic acid, water pollution, elimination kinetics, tissue distribution, perfluorinated compounds
MeSH terms: Animals, Cattle, Decanoic Acids, Environmental Pollutants, Fluorocarbons, Kidney, Liver, Alkanesulfonic Acids

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Half-lives of several polyfluoroalkyl substances (PFAS) in cattle serum and tissues

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