The DOI matches its Crossref record; 38 of the 39 references it cites were found in a registry or an index.
The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis
Open accessAbstract
Background & aims Prolyl and asparaginyl hydroxylases are key oxygen-sensing enzymes that confer hypoxic sensitivity to transcriptional regulatory pathways including the hypoxia inducible factor 1 (HIF-1) and nuclear factor-kappaB (NF-kappaB). Knockout of either HIF-1 or (IKKbeta-dependent) NF-kappaB pathways in intestinal epithelial cells promotes inflammatory disease in murine models of colitis. Both HIF-1 and NF-kappaB pathways are repressed by the action of hydroxylases through the hydroxylation of key regulatory molecules.Methods In this study we have investigated the effects of the hydroxylase inhibitor dimethyloxalylglycine (DMOG) on Caco-2 intestinal epithelial cells in vitro and in a dextran sodium sulfate-induced model of murine colitis.Results DMOG induces both HIF-1 and NF-kappaB activity in cultured intestinal epithelial cells, and is profoundly protective in dextran-sodium sulfate colitis in a manner that is at least in part reflected by the development of an anti-apoptotic phenotype in intestinal epithelial cells, which we propose reduces epithelial barrier dysfunction.Conclusions These data show that hydroxylase inhibitors such as DMOG represent a new strategy for the treatment of inflammatory bowel disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“and to limit inflammation in models of inflammatory bowel disease and LPS-induced shock [117–120].”
From Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function (2013) · cites this paper as [117]
In the citing paper
“Likewise, NF-κB is thought to be largely protective in the intestinal epithelium via the inhibition of enterocyte apoptosis leading to enhanced intestinal barrier function23.”
From Hypoxia: an alarm signal during intestinal inflammation (2010) · cites this paper as [23]
In the citing paper
“Indeed, these studies have shown that both DMOG and FG-4497 provide an overall beneficial influence on multiple parameters studied in chemically induced (trinitrobenzene sulfonic acid [TNBS] or dextran sodium sulfate [DSS] mouse models of colitis.”
From Hypoxia: an alarm signal during intestinal inflammation (2010) · cites this paper as [23]
In the citing paper
“Within the gastrointestinal tract, the PHD inhibitors DMOG and FG-4497 have been used effectively to reduce symptoms in at least two mouse models of colitis23,26.”
From Hypoxia: an alarm signal during intestinal inflammation (2010) · cites this paper as [23]
In the citing paper
“In these mouse models, the drugs were well tolerated with no significant adverse side effects.”
From Hypoxia: an alarm signal during intestinal inflammation (2010) · cites this paper as [23]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nuclear factor-κB in cancer development and progression
Karin, M. (2006) · Nature · doi:10.1038/nature04870 · Cited by 3,519
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
Carmeliet, P., Dor, Y., Herbert, J.-M., Fukumura, D., Brusselmans, K., Dewerchin, M., Neeman, M., Bono, F., Abramovitch, R., Maxwell, P., et al. (1998) · Nature · doi:10.1038/28867 · Cited by 2,502
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
Greten, F. R., Eckmann, L., Greten, T. F., Park, J. M., Li, Z.-W., Egan, L. J., Kagnoff, M. F., & Karin, M. (2004) · Cell · doi:10.1016/j.cell.2004.07.013 · Cited by 2,433
Okayasu, I., Hatakeyama, S., Yamada, M., Ohkusa, T., Inagaki, Y., & NAKAYA, R. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90290-h · Cited by 2,408
Clinicopathologic study of dextran sulfate sodium experimental acute colitis
Shichijo, K., Matuu, M., Ikeda, Y., Naito, S., Ito, M., & Sekine, I. (1998) · The Japanese Journal of Pharmacology · doi:10.1016/s0021-5198(19)41298-5 · Cited by 1,945
Mechanisms of Disease: pathogenesis of Crohn's disease and ulcerative colitis
Sartor, R. B. (2006) · Nature Clinical Practice Gastroenterology & Hepatology · doi:10.1038/ncpgasthep0528 · Cited by 1,806
Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch
Lando, D., Peet, D. J., Whelan, D. A., Gorman, J. J., & Whitelaw, M. L. (2002) · Science · doi:10.1126/science.1068592 · Cited by 1,558
The fundamental basis of inflammatory bowel disease
Strober, W., Fuss, I. J., & Mannon, P. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30587 · Cited by 1,337
Epithelial NEMO links innate immunity to chronic intestinal inflammation
Nenci, A., Becker, C., Wullaert, A., Gareus, R., Loo, G., Danese, S., Huth, M., Nikolaev, A., Neufert, C. F., Madison, B., et al. (2007) · Nature · doi:10.1038/nature05698 · Cited by 1,077
Cummins, E. P., Berra, E., Comerford, K. M., Ginouves, A., Fitzgerald, K. T., Seeballuck, F., Godson, C., Nielsen, J. E., Moynagh, P., Pouyssegur, J., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602235103 · Cited by 788
Self-citation
Flagged first, then by citations
1 of the 39 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 301–400 of 408
HIF‐1α controls palatal wound healing by regulating macrophage motility via S1P/S1P 1 signaling axis
Hutami, I. R., Izawa, T., Khurel‐Ochir, T., Sakamaki, T., Iwasa, A., Tomita, S., & Tanaka, E. I. (2021) · Oral Diseases · doi:10.1111/odi.13856 · Cited by 13
Cognitive Enhancer Noopept Activates Transcription Factor HIF-1
Зайнуллина, Л. Ф., Ivanova, T. V., Sadovnikov, S. V., Vakhitova, Y. V., & Середенин, С. Б. (2020) · Doklady Biochemistry and Biophysics · doi:10.1134/s1607672920050129 · Cited by 13
Etiology of GVHD: Alloreactivity or Impaired Cellular Adaptation?
Manjili, M. H., & Toor, A. A. (2014) · Immunological Investigations · doi:10.3109/08820139.2014.953636 · Cited by 13
“Additionally, in a model of inflammatory bowel disease (IBD), the pharmacologic activation of HIF-1 by prolyl hydroxylase inhibitors prevents colitis (Cummins et al., 2008; Robinson et al., 2008).”
BackgroundThe signaling pathway of hypoxia inducible factor in regulating gut homeostasis
Liu, W., Fan, X., Jian, B., Wen, D., Wang, H., Liu, Z., & Li, B. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1289102 · Cited by 13
Ryan, S. M., Crowe, L., Cruz, S. N. A., Galbraith, M. D., O’Brien, C., Hammer, J. A., Bergin, R., Kellett, S. K., Markey, G. E., Benson, T. M., et al. (2024) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2024.07.030 · Cited by 14
Targeting Hypoxia to Augment Mucosal Barrier Function
Kelly, C. J. (2012) · Journal of Epithelial Biology & Pharmacology · doi:10.2174/1875044301205010067 · Cited by 13
“Furthermore, it is unclear if other models will reproduce the augmented IgA transcytosis following hypoxia exposure given that the protective role of HIF signaling in chronic inflammatory hypoxia [27] [28], has not always been in agreement with those of acute ischemia/ reperfusion [29].”
CARD3 Deficiency Protects Against Colitis Through Reduced Epithelial Cell Apoptosis
Yu, S. J., Liu, Y., Deng, Y., Zhu, X. Y., Zhan, N., & Dong, W. G. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000322 · Cited by 12
“2015 A common feature of all IBD regardless of the underlying cause is the loss of intestinal epithelial barrier function because of excessive epithelial cell death, an event that allows the nonspecific movement of luminal antigenic material into the submucosa.(23,24) The resulting inflammatory response drives further…”
BackgroundHookham, M. B., Ali, I., O’Neill, C. L., Hackett, E. E., Lambe, M. H., Schmidt, T., Medina, R. J., Chamney, S., Rao, B., McLoone, E., et al. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0430-0 · Cited by 12
“Despite the robust increase in PlGF protein expression in 1% O2 or in response to DMOG, an inhibitor of HIF prolyl hydroxylases [37], previous analysis of the PlGF promoter and enhancer regions did not identify any the putative binding sites for HIFs (hypoxia response elements (HREs)) [38–40].”
BackgroundShang, L., Kang, W., Li, S., & Ge, S. (2018) · Clinical Oral Investigations · doi:10.1007/s00784-018-2733-2 · Cited by 12
SUMOylation indirectly suppresses activity of the HIF-1α pathway in intestinal epithelial cells
Malkov, M. I., Flood, D., & Taylor, C. T. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105280 · Cited by 11
“Previous work from our group has shown HIF-1 α to be highly protective in models of in fl ammatory bowel disease (17 – 19).”
BackgroundSelf-citationPabari, R. M., Tambuwala, M. M., Lajczak, N., Aljabali, A. A. A., Kirby, B. P., Keely, S. J., & Ramtoola, Z. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120717 · Cited by 11
Self-citationHydroxylase Inhibition Selectively Induces Cell Death in Monocytes
Crifò, B., Schaible, B., Brown, E., Halligan, D. N., Scholz, C. C., Fitzpatrick, S. F., Kirwan, A. M., Roche, H. M., Criscuoli, M., Naldini, A., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1800912 · Cited by 11
“In murine models of colitis, pharmacologic hydroxylase inhibition reduces intestinal inflammation, at least in part, through reduced apoptosis of epithelial cells, resulting in enhanced barrier function (20).”
BackgroundSelf-citationKim, D. H., Cha, J., Song, Y. W., Woo, K. M., & Jung, U. (2019) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.34483 · Cited by 11
Ma, X., Wang, X., Cao, J., Geng, Z., & Wang, Z. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095692 · Cited by 11
“Some classical chelators, such as N-oxalylglycine (NOG) [26], dimethyloxalylglycine (DMOG) [27], ethyl-3, 4-dihydroxybenzoate (3, 4-DHB) [12], and deferoxamine mesylate (DFO) [12], can competitively inhibit the activity of PHD and stabilize HIF-1a to repair chronic disease anemia and neuronal injury.”
BackgroundHypoxia and its Emerging Therapeutics in Neurodegenerative, Inflammatory and Renal Diseases
Bhatia, D., Ardekani, M. S., Shi, Q., & Movafagh, S. (2017) · Hypoxia and Human Diseases · doi:10.5772/66089 · Cited by 17
“In these studies PHD inhibitors decreased clinical symptoms in murine models of colitis and thus present promising therapeutic targets for IBD [153, 155, 156].”
BackgroundMattia, M. D., Sallese, M., Neri, M., & Lopetuso, L. R. (2024) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izae046 · Cited by 13
Growth Factors in the Intestinal Tract
Schumacher, M. A., Danopoulos, S., Alam, D. A., & Frey, M. R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809954-4.00003-7 · Cited by 10
Angiogenesis in Rheumatoid Arthritis
Konisti, S., Kiriakidis, S., & Paleolog, E. M. (2013) · Springer eBooks · doi:10.1007/978-3-7091-1428-5_16 · Cited by 9
Tada, Y., Ogawa, M., Watanabe, R., Zempo, H., Takamura, C., Suzuki, J.-I., Dan, T., Miyata, T., Isobe, M., & Komuro, I. (2014) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2014.855196 · Cited by 9
“Other reports claimed beneficial roles of HIF-1a on inflammatory diseases through modulating adenosine signaling and functions of endothelial or epithelial cells [63-65].”
BackgroundEvaluation of Quantitative Imaging Biomarkers in the DSS Colitis Model
Beltzer, A., Kaulisch, T., Bluhmki, T., Schoenberger, T., Stierstorfer, B., & Stiller, D. (2016) · Molecular Imaging and Biology · doi:10.1007/s11307-016-0937-x · Cited by 9
“DMOG treatment known to be effective in DSS-induced colitis [28] resulted in reduced colonic inflammation of colitis mice as detected by decreased [(18)F]FDG uptake in the colons of treated compared to vehicle animals.”
Wang, K., Zhu, R., Li, J., Zhang, Z., Wen, X. L., Chen, H., & Sun, L. (2022) · Clinical Rheumatology · doi:10.1007/s10067-021-06035-5 · Cited by 10
Schützhold, V., Gravemeyer, J., Bicker, A., Hager, T., Padberg, C., Schäfer, J., Wrobeln, A., Steinbrink, M., Zeynel, S., Hankeln, T., et al. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100418 · Cited by 9
Ward, J. B. J., Lawler, K., Amu, S., Taylor, C. T., Fallon, P. G., & Keely, S. J. (2010) · The FASEB Journal · doi:10.1096/fj.10-166983 · Cited by 9
“HIF-hydroxylases, PHDs and FIH, are enzymes that are critically dependent on O2 for their activity and that regulate the expression of key transcription factors that control cellular responses to O2 availability (10, 20).”
BackgroundResultSelf-citationde Zoeten, E. F., Battista, K. D., Colson, S. B., Lovell, M. A., Kessler, B. E., Isfort, R. W., Fennimore, B. P., Onyiah, J. C., Kao, D. J., Yeckes, A. R., et al. (2020) · Hypoxia · doi:10.2147/hp.s219049 · Cited by 9
“The first study used the prolyl hydroxylase (PHD) inhibitor DMOG for the treatment of intestinal inflammation during chemically induced colitis.(51) A second study used the HIF stabilizer FG-4497 during TNBS-induced intestinal inflammation.”
MethodSelf-citationVavricka, S. R., Ruiz, P. A., Scharl, S., Biedermann, L., Scharl, M. M., de Vallière, C., Lundby, C., Wenger, R. H., Held, L., Merz, T. M., et al. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-013477 · Cited by 9
Zhu, Y., Qiao, S., Pang, Y., Wang, H., & Zhou, Y. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s490823 · Cited by 8
Rowland, K. J., Yao, J., Wang, L., Erwin, C. R., Maslov, K., Wang, L. V., & Warner, B. W. (2013) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2013.03.031 · Cited by 10
Fundamental role for the creatine kinase pathway in protection from murine colitis
Hall, C. H. T., Lanis, J. M., Dowdell, A. S., Murphy, E. M., Bhagavatula, G., Neuhart, R. M., Sai, K. Y. V., & Colgan, S. P. (2023) · Mucosal Immunology · doi:10.1016/j.mucimm.2023.09.002 · Cited by 8
Wu, W., Sun, Y., Niu, S., Li, X., Chen, L., Xie, S., Chang, L., Wei, S., Jing, M., Li, H., et al. (2024) · Phytotherapy Research · doi:10.1002/ptr.8389 · Cited by 8
Opposing regulation and roles for PHD3 in lung dendritic cells and alveolar macrophages
Tavernier, S. J., Vanlangenakker, N., Vetters, J., Carmeliet, P., Janssens, S., & Lambrecht, B. N. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.3a0916-405r · Cited by 8
Vitamin D Receptor-Dependent Protective Effect of Moderate Hypoxia in a Mouse Colitis Model
Wang, Z., Yang, H. B., Lv, H., Huang, C., & Qian, J. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.876890 · Cited by 8
Molecular oxygen sensing: implications for visceral surgery
Kiss, J., Kirchberg, J., & Schneider, M. (2012) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-012-0930-z · Cited by 8
Schnoor, M. (2012) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.s3-003 · Cited by 8
“Moreover, inhibition of PHD1 by dimethyloxalylglycine (DMOG) resulted in increased activity of both HIF-1α and NF-κB and protected against DSS-induced colitis through induction of antiapoptotic genes in IEC [115].”
BackgroundHypoxia Primes Human ISCs for Interleukin-Dependent Rescue of Stem Cell Activity
Rivera, K. R., Bliton, R. J., Burclaff, J., Czerwinski, M. J., Liu, J., Trueblood, J. M., Hinesley, C. M., Breau, K. A., Deal, H. E., Joshi, S., et al. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.07.012 · Cited by 10
He, W., Xu, J., Zhao, J., Wang, Z., Kong, R., Zhao, F., Li, Y., Meng, H., & Zheng, Y. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124086 · Cited by 7
Prolyl Hydroxylase Inhibition Mitigates Pouchitis
Harnoss, J. M., Gebhardt, J. M., Radhakrishnan, P., Leowardi, C., Burmeister, J., Halligan, D. N., Yuan, S., Kennel, K. B., Strowitzki, M. J., Schaible, A., et al. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izz218 · Cited by 8
Self-citationGalan, C. D., Vos, M. D., Hindryckx, P., Laukens, D., & Welden, S. V. (2021) · Biology · doi:10.3390/biology10090887 · Cited by 7
“In line with colonic inflammation [2,11,19], ileitis increased pimonidazole staining (p = 0.”
BackgroundResultInfluentialThe HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer
Kennel, K. B., Burmeister, J., Radhakrishnan, P., Giese, N. A., Giese, T., Salfenmoser, M., Gebhardt, J. M., Strowitzki, M. J., Taylor, C. T., Wielockx, B., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.153337 · Cited by 7
Self-citationRoxadustat protect mice from DSS-induced colitis in vivo by up-regulation of TLR4
Feng, Z., Cheng, Y., Wang, Y., Qu, S., Du, J., Gao, F., Liu, C., Wang, Q., & Cai, J. (2023) · Genomics · doi:10.1016/j.ygeno.2023.110585 · Cited by 7
DiGuilio, K. M., Valenzano, M. C., Rybakovsky, E., & Mullin, J. M. (2018) · BMC Gastroenterology · doi:10.1186/s12876-017-0731-5 · Cited by 7
“In dextran-sodium sulfate-induced murine colitis, the hydroxylase inhibitor, DMOG, was found to be protective regarding similar parameters [17].”
Palaniyandi, S., Kumari, R., Radhakrishnan, S. V., Strattan, E., Hakim, N., Munker, R., Kesler, M., & Hildebrandt, G. C. (2020) · Transplantation · doi:10.1097/tp.0000000000003383 · Cited by 8
“In the literature, beneficial effects of HIF-stabilizing therapy by PHIs like DMOG have been found for a wide variety of inflammatory diseases such as IBD, colitis, and ischemic disorders.(7) Studies have shown that hypoxia occurs concurrently with inflammatory responses,(19) lung injury,(20) IBD, and colitis in mice.”
BackgroundXu, M., Taylor, M. S., Hill, B. G., Li, X., Rouchka, E. C., McClain, C. J., & Song, M. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000572 · Cited by 9
“[13] In the current study, we demonstrated that pharmacological activation of HIF-1 and genetic forced intestine HIF-1 overexpression protects against western diet – induced MASLD and was associated with reduced systemic inflammatory response and hepatic bacterial translocation.”
The transcription factor HIF-1α in NKp46+ ILCs limits chronic intestinal inflammation and fibrosis
Nelius, E., Fan, Z., Sobecki, M., Krzywińska, E., Nagarajan, S., Ferapontova, I., Gotthardt, D., Takeda, N., Sexl, V., & Stockmann, C. (2024) · Life Science Alliance · doi:10.26508/lsa.202402593 · Cited by 6
“Our observation are, however, in line with various studies showing that genetic or pharmacologic HIF stabilization in gut epithelial cells is protective against mucosal damage ( Cummins et al 2008, Tambuwala et al., 2010, 2015).”
Prolyl hydroxylase 2 is dispensable for homeostasis of intestinal epithelium in mice
Xie, Y., Yuan, T., Qin, Y., Weng, Z., & Fang, J. S. (2018) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmy037 · Cited by 6
Butyrate and Intestinal Homeostasis: Effects on the Intestinal Microbiota and Epithelial Hypoxia
Bortoluzzi, C., Castro, F. L. D. S., & Kogut, M. H. (2022) · The microbiomes of humans, animals, plants, and the environment · doi:10.1007/978-3-030-90303-9_4 · Cited by 6
Actions of Adenosine on Cullin Neddylation: Implications for Inflammatory Responses
Curtis, V. F., Ehrentraut, S., & Colgan, S. P. (2014) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2014.10.002 · Cited by 6
“PHD inhibitors have been previously investigated for their therapeutic potential in various disease models, such as murine colitis [36,37].”
BackgroundYin, J., Mao, X., Shang, P., Chen, S., Yang, G., He, H., He, C., & Zhou, X. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.102837 · Cited by 5
“Dimethyloxalylglycine (DMOG), a cell-permeable and competitive inhibitor of PHD, can prevent HIF-1 α degradation and enable its stabilization under normoxia, thereby activating the expression of angiogenic factors [29].”
Yang, S., Cui, Y., Ma, R., Yu, S., Zhang, H., Zhao, P., & He, J. (2025) · Biomolecules · doi:10.3390/biom15020256 · Cited by 5
“There are also oxygen concentrations and other signaling molecules that can make a difference [42,43].”
Hypoxia Reduces the Transcription of Fibrotic Markers in the Intestinal Mucosa
Simmen, S., Maane, M., Rogler, S., Baebler, K., Lang, S., Cosín‐Roger, J., Atrott, K., Frey-Wagner, I. M., Spielmann, P., Wenger, R. H., et al. (2021) · Inflammatory Intestinal Diseases · doi:10.1159/000513061 · Cited by 5
Han, Y., Jia, R., Zhang, J., Zhu, Q., Wang, X., Ji, Q., & Zhang, W. (2023) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2022.0194 · Cited by 4
“Stabilizing HIF-1 a with prolyl hydroxylase inhibitors could reduce intestinal inflammation (Colgan and Taylor, 2010; Cummins et al, 2008; Keely et al, 2014; Robinson et al, 2008; Watts and Walmsley, 2019; Xue et al, 2014).”
Hindryckx, P., Laukens, D., & Vos, M. D. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21589 · Cited by 5
“Furthermore, we and others found that HIF-1 can induce an antiapoptotic phenotype in IECs, which may also contribute to preservation of barrier integrity.(18,19) Further evidence for HIF-1 upregulation as a potential therapeutic option in IBD was provided some years later (2008).”
BackgroundHypoxia impacts small intestinal organoid stemness and differentiationPreprint
Lan, X., Qiu, P., & Mou, C. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.30.573689 · Cited by 6
Regulation of pathologic fibroblast functions in digestive diseases: a role for hypoxia?
Ohlendieck, C. M., Matellan, C., & Manresa, M. C. (2025) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00277.2024 · Cited by 5
DeMichele, E., Sosnowski, O., Flood, D., Taylor, C. T., Lewis, I. A., Allain, T., & Buret, A. G. (2025) · Scientific Reports · doi:10.1038/s41598-025-13635-7 · Cited by 5
“Cells were cultured between passages 20 and 35 with high glucose DMEM media (Gibco) containing 4.5 g/L of glucose, supplemented with 10% heat-inactivated FBS and 50 U/mL Penicillin-Streptomycin.”
InfluentialSelf-citationElectrochemically induced in vitro focal hypoxia in human neurons
Wong, J. J. Y., Varga, B. V., Káradóttir, R. T., & Hall, E. A. H. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.968341 · Cited by 4
“The level of eLOSinduced HIF-1α was comparable with chemical stabilisation by DMOG.”
BackgroundInfluentialPinto-Cardoso, R., Bessa-Andrês, C., Pereira-Costa, F., Neiva, R., Martins-Ferreira, R., Leal, B., Catelas, D. N., Vilaça, A., Oliveira, A., Pelletier, J., et al. (2025) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.5c00190 · Cited by 4
Yum, S., Park, H., Hong, S., Jeong, S., Kim, W., & Jung, Y. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.12.081 · Cited by 4
Clayton, D. B., Tong, C. M. C., Li, B., Taylor, A. S., De, S., Mason, M. D., Dudley, A. G., Davidoff, O., Kobayashi, H., & Haase, V. H. (2022) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00344.2021 · Cited by 4
Zhang, W., Tan, Y., Ai, J., Luo, F., Su, X., Wu, Q., Su, L., Pan, J., Zheng, Q., Li, B., et al. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-5050 · Cited by 2
“HIF-PHI treatment ameliorated intestinal inflammation with reduction of inflammatory lesions and proinflammatory cytokines (14,39,40).”
Fets, L., Bevan, N., Nunes, P. M., Campos, S., dos Santos, M. S., Sherriff, E., MacRae, J. I., House, D., & Anastasiou, D. (2022) · Communications Biology · doi:10.1038/s42003-022-03805-y · Cited by 4
Gupta, A., Song, M. H., Youn, D. H., Ku, D., Nair, V. S., & Oh, K. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1330011 · Cited by 3
NMR-Based Metabolomic Analysis of Normal and Inflamed Gut
Kao, D. J., Lanis, J. M., Alexeev, E. E., & Kominsky, D. J. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3603-8_8 · Cited by 3
Role of Hypoxia-Inducible Factor (HIF) in the Initiation of Cancer and Its Therapeutic Inhibitors
Eda, S. R., Vadde, R., & Jinka, R. (2017) · Springer eBooks · doi:10.1007/978-981-10-6728-0_10 · Cited by 3
Hong, S., Yum, S., Ha, N., & Jung, Y. (2010) · Analytical Biochemistry · doi:10.1016/j.ab.2010.08.013 · Cited by 3
Modulation of Innate Immunity by Hypoxia
Riboldi, E., & Sica, A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801968-9.00004-0 · Cited by 3
Chen, W., Huang, C., Tang, D., Wan, J., Zhou, X., Wu, C., & Yang, X. L. (2024) · American Journal of Translational Research · doi:10.62347/ihnx2675 · Cited by 2
Gomes, L. A. B., Smith, O. E., Bollwein, H., & Kowalewski, M. P. (2025) · Animals · doi:10.3390/ani15040595 · Cited by 2
“Informed Consent Statement: Not applicable.”
Shen, Y., Luo, B., Zhang, Q., Li, H., Hu, Y. C., & Chen, M. H. (2025) · Scientific Reports · doi:10.1038/s41598-025-95451-7 · Cited by 2
“Several studies have shown that activation of HIF in intestinal epithelial cells prevents colitis 94,95 .”
Silina, M. V., Dzhalilova, D. S., & Makarova, O. V. (2025) · Moscow University Biological Sciences Bulletin · doi:10.3103/s0096392525600681 · Cited by 2
Xu, J., Xu, L., Li, L. T., You, Q., & Cha, L. (2014) · Genetics and Molecular Research · doi:10.4238/2014.july.25.29 · Cited by 2
“Recently, a growing number of evidences have shown that HIF-1A gene mutations might play important roles in the development of digestive tract cancers (Cummins et al., 2008).”
BackgroundDengler, F., Sova, S., Salo, A. M., Mäki, J. M., Koivunen, P., & Myllyharju, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084038 · Cited by 3
“, in Crohn’s disease or ulcerative colitis [25,26,39,40] and that its inhibition could be beneficial in these conditions [18,29], while a knockout of Hif-p4h-2 or 3 did not affect inflammatory lesions in the guts [26].”
BackgroundRoxadustat Protect Mice from DSS-Induced Colitis Vivo by Up-Regulation of TLR4Preprint
Feng, Z., Cheng, Y., Wang, Y., Qu, S., Du, J., Gao, F., Liu, C., Wang, Q., & Cai, J. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4172648 · Cited by 2
Stage-Specific Effects of Hypoxia on Interstitial Lung Disease
Artham, S., & Somanath, P. R. (2017) · InTech eBooks · doi:10.5772/66817 · Cited by 1
Gwak, M.-G., Kim, M.-S., Park, S., Oh, S., Kim, Y., Kim, J., & Chang, S. (2025) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaf155 · Cited by 2
Matellan, C., Raphael, B., Jones, G., Nwaeziegwe, M., Balfe, S., Ohlendieck, C. M., Bauset, C., Chathail, M. B. N., Kennedy, C., Doogan, K. L., et al. (2026) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjag012 · Cited by 1
Effect of cigarette smoke extract on the intestinal microenvironment of ulcerative colitis tissue
Cannon, A., Clarke, N. E., MacCarthy, F., Dunne, C., Kevans, D., Mahmud, N. U., Lysaght, J., & O'Sullivan, J. N. (2020) · JGH Open · doi:10.1002/jgh3.12422 · Cited by 1
HIF-опосредованные механизмы взаимосвязи устойчивости к гипоксии и опухолевого роста
Dzhalilova, D. S., & Makarova, O. V. (2021) · Biochemistry (Moscow) · doi:10.31857/s0320972521100018 · Cited by 1
Regulation of Epithelial HIF by Probiotic Escherichia coliPreprint
Dowdell, A. S., Roer, R. L., Bhagavatula, G., Cartwright, I. M., Cohen, R. H., Countess, J. A., Koch, S. D., Lee, J. S., Steiner, C. A., Thompson, N. T., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.14.654147 · Cited by 1
Regulation of Oxygen Homeostasis by Prolyl Hydroxylase Domains
Takeda, K., & Fong, G. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-857-7_22
“Several studies indicate that pharmacological inhibition of PHDs reduced inflammatory reactions in colitis and ischemic heart [87, 116 , 117].”
BackgroundPhysiological and Therapeutic Vascular Remodeling Mediated by Hypoxia-Inducible Factor 1
Sarkar, K., & Semenza, G. L. (2010) · Biological and medical physics series · doi:10.1007/978-1-4419-7835-6_6
Regulated Extracellular Nucleotide Metabolism and Function at the Mucosa
MacManus, C. F., Eltzschig, H. K., & Colgan, S. P. (2010) · Springer eBooks · doi:10.1007/978-90-481-3435-9_8
“hypoxia at the site of inflammation [10, 50].”
Aaishwarya, B. D., Jayvadan, K. P., & Bharat, M. (2012) · International Research Journal of Pharmacy
Review The updated biology of hypoxia-inducible factor
Greer, S. N., Metcalf, J. L., Wang, Y., & Ohh, M. (2016)
hypoxia: an alarm signal during intestinal
Taylor, C. T. (2010)
Self-citationInflammationShifts in Immunity and
Kominsky, D. J., & Campbell, E. L. (2010)
Hypoxia and the mechanisms regulating inflammatory tissue destruction in tuberculosis
Belton, M. (2014) · doi:10.25560/42775
“DMOG pre-treatment has been shown to be protective in a murine model of colitis [180] and protective against LPS-induced sepsis [181].”
BackgroundSelenium modulation of gut epithelial cell stress responses
Moore, A. N. (2017)
Robrahn, L., Dupont, A., Jumpertz, S., Zhang, K., Holland, C. H., Guillaume, J., Rappold, S., Cerovic, V., Sáez-Rodríguez, J., Hornef, M. W., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.16.426940
Jia, B., Tan, X.-Y., Liu, X., & Li, X. (2021) · Research Square · doi:10.21203/rs.3.rs-199959/v1
Weiss, M. J. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732587239.793577754
Role of sphingolipids in inflammatory carciongensis
El-Hindi, K. (2022) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) · doi:10.21248/gups.71949
Cheng, M. I., Hong, L., Chen, B., Chin, S. C., Luthers, C. R., Bustillos, C. G., Sheikh, S. Z., & Su, M. A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.27.550746
Asselborn, C., Makar, A. N., Marques, J. G., Akan, A. B., Yiapanas, A., Jennings, C., López, A. P., Wills, J. C., Unciti‐Broceta, A., Myant, K., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.31.702998
“⁻ Peptides were desalted on C18 StageTips and analysed on an Orbitrap Fusion Lumos Tribrid Mass Spectrometer (Thermo Fisher Scientific) coupled to an Ultimate 3000 Nano LC with a C18 packed emitter (Aurora, IonOptiks).”
Li, J., Duan, Y., Tao, Y., Li, Y., Gao, H., Zhou, L., Ma, K., Zeng, Q., Zhou, Y., Li, W., et al. (2026) · Aquaculture Reports · doi:10.1016/j.aqrep.2026.103535
Stage-specific changes in the Krebs cycle network regulate human erythroid differentiation
Romano, M. (2018) · theses.fr (ABES) · doi:10.70675/4312681cz0207z4923zb100z879f8a73681c
The role of HIF-1α in innate immune mechanisms and autoimmunity: A double-edged sword
Chapple, M. L., Zaldumbide, A., & Fagundes, R. R. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.111429
Asselborn, C., Makar, A. N., Marques, J. G., Akan, A. B., Yiapanas, A., Jennings, C., López, A. P., Wills, J. C., Unciti‐Broceta, A., Myant, K., et al. (2026) · eLife · doi:10.7554/elife.110991.1
Metadata
- Authors
- Cummins, E. P., Seeballuck, F., Keely, S. J., Mangan, N. E., Callanan, J. J., Fallon, P. G., & Taylor, C. T.
- Affiliations
- University College Dublin (IE)
- Royal College of Surgeons in Ireland (IE)
- Trinity College Dublin (IE)
- Corresponding author
- Taylor, Cormac T.
- ORCID
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 134
- Issue
- 1
- Pages
- 156-165.e1
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2005539293
- Cited by
- 407
- References
- 39
- Citations by year
- 2026: 13 · 2025: 10 · 2024: 18 · 2023: 18 · 2022: 21 · 2021: 24 · 2020: 24 · 2019: 18 · 2018: 28 · 2017: 25 · 2016: 31 · 2015: 23 · 2014: 22 · 2013: 28 · 2012: 27
- FWCI
- 9.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Health Research Board
- Science Foundation Ireland
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Microscopic Colitis
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Keywords
- dimethyloxalylglycine, colitis, inflammatory bowel disease, HIF-1, NF-κB, prolyl hydroxylase, asparaginyl hydroxylase, intestinal epithelial cells, Caco-2 cells, DSS-induced colitis, apoptosis, epithelial barrier dysfunction, hypoxia
- MeSH terms
- Amino Acids, Dicarboxylic, Animals, Colitis, Disease Models, Animal, Enzyme Inhibitors, Female, Humans, Mixed Function Oxygenases, Mice, Inbred C57BL, NF-kappa B, Cell Culture Techniques, Caco-2 Cells, Mice, Hypoxia-Inducible Factor 1, alpha Subunit
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
