The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Rotaviruses: From Pathogenesis to Vaccination
Open accessAbstract
Rotaviruses cause life-threatening gastroenteritis in children worldwide; the enormous disease burden has focused efforts to develop vaccines and led to the discovery of novel mechanisms of gastrointestinal virus pathogenesis and host responses to infection. Two live-attenuated vaccines for gastroenteritis (Rotateq and Rotarix) have been licensed in many countries. This review summarizes the latest data on these vaccines, their effectiveness and challenges to global vaccination. Recent insights into rotavirus pathogenesis are also discussed, including information on extra-intestinal infection, viral antagonists of the interferon response and the first described viral enterotoxin. Rotavirus-induced diarrhea is now considered to be a disease that can be prevented through vaccination, although there are many challenges to achieving global effectiveness. Molecular biology studies of rotavirus replication and pathogenesis have identified unique viral targets that might be useful in developing therapies for immunocompromised children with chronic infections.
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Cites
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Cited by
Bányai, K., Estes, M. K., Martella, V., & Parashar, U. D. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31128-0 · Cited by 445
Self-citationEpithelial WNT ligands are essential drivers of intestinal stem cell activation
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Rigo-Adrover, M., Pérez-Berezo, T., Ramos-Romero, S., van Limpt, K., Knipping, K., Garssen, J., Knol, J., Franch, À., Castell, M., & Pérez-Cano, F. J. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114516004566 · Cited by 34
Metadata
- Authors
- Greenberg, H. B., & Estes, M. K.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 136
- Issue
- 6
- Pages
- 1939-1951
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2034323018
- Cited by
- 440
- References
- 60
- FWCI
- 16.33
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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