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The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Radioembolization for Hepatocellular Carcinoma Using Yttrium-90 Microspheres: A Comprehensive Report of Long-term Outcomes

Open access
Salem, Riad, Lewandowski, Robert J., Mulcahy, Mary F., Riaz, Ahsun, Ryu, Robert K., Ibrahim, Saad, Atassi, Bassel, Baker, Talia, Gates, Vanessa, Miller, Frank H., Sato, Kent T., Wang, Ed, Gupta, Ramona, Benson, Al B., Newman, Steven B., Omary, Reed A., Abecassis, Michael, Kulik, Laura·2010·Gastroenterology
DOI 10.1053/j.gastro.2009.09.006
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Abstract

BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) has limited treatment options; long-term outcomes following intra-arterial radiation are unknown. We assessed clinical outcomes of patients treated with intra-arterial yttrium-90 microspheres (Y90). METHODS: Patients with HCC (n = 291) were treated with Y90 as part of a single-center, prospective, longitudinal cohort study. Toxicities were recorded using the Common Terminology Criteria version 3.0. Response rate and time to progression (TTP) were determined using World Health Organization (WHO) and European Association for the Study of the Liver (EASL) guidelines. Survival by stage was assessed. Univariate/multivariate analyses were performed. RESULTS: A total of 526 treatments were administered (mean, 1.8; range, 1-5). Toxicities included fatigue (57%), pain (23%), and nausea/vomiting (20%); 19% exhibited grade 3/4 bilirubin toxicity. The 30-day mortality rate was 3%. Response rates were 42% and 57% based on WHO and EASL criteria, respectively. The overall TTP was 7.9 months (95% confidence interval, 6-10.3). Survival times differed between patients with Child-Pugh A and B disease (A, 17.2 months; B, 7.7 months; P = .002). Patients with Child-Pugh B disease who had portal vein thrombosis (PVT) survived 5.6 months (95% confidence interval, 4.5-6.7). Baseline age; sex; performance status; presence of portal hypertension; tumor distribution; levels of bilirubin, albumin, and alpha-fetoprotein; and WHO/EASL response rate predicted survival. CONCLUSIONS: Patients with Child-Pugh A disease, with or without PVT, benefited most from treatment. Patients with Child-Pugh B disease who had PVT had poor outcomes. TTP and overall survival varied by patient stage at baseline. These data can be used to design future Y90 trials and to describe Y90 as a potential treatment option for patients with HCC.

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Metadata

Authors
Salem, R., Lewandowski, R. J., Mulcahy, M. F., Riaz, A., Ryu, R. K., Ibrahim, S., Atassi, B., Baker, T., Gates, V., Miller, F. H., Sato, K. T., Wang, E., Gupta, R., Benson, A. B., Newman, S. B., Omary, R. A., Abecassis, M., & Kulik, L.
Venue
Gastroenterology
Publisher
Elsevier BV
Published
2010-01
Volume
138
Issue
1
Pages
52-64
ISSN
0016-5085 (ISSN-L)
DOI
10.1053/j.gastro.2009.09.006
OpenAlex
W1998417832
Cited by
1,074
References
44
FWCI
31.49
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Radioembolization for Hepatocellular Carcinoma Using Yttrium-90 Microspheres: A Comprehensive Report of Long-term Outcomes. https://app.cochat.ai/papers/10.1053/j.gastro.2009.09.006
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Salem, R., Lewandowski, R. J., Mulcahy, M. F., Riaz, A., Ryu, R. K., Ibrahim, S., Atassi, B., Baker, T., Gates, V., Miller, F. H., Sato, K. T., Wang, E., Gupta, R., Benson, A. B., Newman, S. B., Omary, R. A., Abecassis, M., & Kulik, L. (2010). Radioembolization for Hepatocellular Carcinoma Using Yttrium-90 Microspheres: A Comprehensive Report of Long-term Outcomes. Gastroenterology. https://doi.org/10.1053/j.gastro.2009.09.006

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.