Modulation of Hepatic Fibrosis by c-Jun-N-Terminal Kinase Inhibition

Liver fibrosis

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Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

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Mechanisms of Hepatic Fibrogenesis

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TLR4 enhances TGF-β signaling and hepatic fibrosis

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Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

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The JNK signal transduction pathway

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The JNK signal transduction pathway

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Prophylactic Treatment with Cerium Oxide Nanoparticles Attenuate Hepatic Ischemia Reperfusion Injury in Sprague Dawley Rats

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Uses for JNK: the Many and Varied Substrates of the c-Jun N-Terminal Kinases

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NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis

Bataller, R. A., Schwabe, R. F., Choi, Y. H., Yang, L., Paik, Y. H., Lindquist, J. N., Qian, T., Schoonhoven, R., Hagedorn, C. H., Lemasters, J. J., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18212 · Cited by 566 · see citing works

Regulation and function of the JNK subgroup of MAP kinases

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C-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity

Gunawan, B. K., Liu, Z., Han, D., Hanawa, N., Gaarde, W. A., & Kaplowitz, N. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.03.045 · Cited by 471 · see citing works

Loss of hepatic NF-κB activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation

Sakurai, T., Maeda, S., Chang, L., & Karin, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603499103 · Cited by 398 · see citing works

Distinct Roles for JNK1 and JNK2 in Regulating JNK Activity and c-Jun-Dependent Cell Proliferation

Sabapathy, K., Hochedlinger, K., Nam, S. Y., Bauer, A., Karin, M., & Wagner, E. F. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.08.028 · Cited by 397 · see citing works

JNK1 but not JNK2 promotes the development of steatohepatitis in mice

Schattenberg, J. M., Singh, R., Wang, Y., Lefkowitch, J. H., Rigoli, R. M., Scherer, P. E., & Czaja, M. J. (2006) · Hepatology · doi:10.1002/hep.20999 · Cited by 384 · see citing works

Hepatocytes Do Not Undergo Epithelial-Mesenchymal Transition in Liver Fibrosis in Mice

Taura, K., Miura, K., Iwaisako, K., Österreicher, C. H., Kodama, Y., Penz-Österreicher, M., & Brenner, D. A. (2010) · Hepatology · doi:10.1002/hep.23368 · Cited by 336 · see citing works

Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation

Hui, L., Zatloukal, K., Scheuch, H., Stępniak-Konieczna, E., & Wagner, E. F. (2008) · Journal of Clinical Investigation · doi:10.1172/jci37156 · Cited by 308 · see citing works

IKKβ Is Required for Prevention of Apoptosis Mediated by Cell-Bound but Not by Circulating TNFα

Maeda, S., Chang, L., Li, Z.-W., Luo, J.-L., Leffert, H., & Karin, M. (2003) · Immunity · doi:10.1016/s1074-7613(03)00301-7 · Cited by 286 · see citing works

Inhibition of inhibitor of κB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis

Oakley, F., Meso, M., Iredale, J. P., Green, K., Marek, C. J., Zhou, X., May, M. J., Millward‐Sadler, H., Wright, M. C., & Mann, D. A. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.10.003 · Cited by 265 · see citing works

Human Hepatic Stellate Cells Express CCR5 and RANTES to Induce Proliferation and Migration

Schwabe, R. F., Bataller, R., & Brenner, D. A. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00215.2003 · Cited by 252 · see citing works

C–Jun–N–Terminal Kinase Drives Cyclin D1 Expression and Proliferation During Liver Regeneration

Schwabe, R. F., Bradham, C. A., Uehara, T., Hatano, E., Bennett, B. L., Schoonhoven, R., & Brenner, D. A. (2003) · Hepatology · doi:10.1053/jhep.2003.50135 · Cited by 251 · see citing works

A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations

Magness, S. T., Bataller, R. A., Yang, L., & Brenner, D. A. (2004) · Hepatology · doi:10.1002/hep.20427 · Cited by 246 · see citing works

Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance†

Singh, R., Wang, Y., Xiang, Y., Tanaka, K. E., Gaarde, W. A., & Czaja, M. J. (2008) · Hepatology · doi:10.1002/hep.22578 · Cited by 224 · see citing works

JNK mediates hepatic ischemia reperfusion injury

Uehara, T., Bennett, B. L., Sakata, S. T., Satoh, Y., Bilter, G. K., Westwick, J. K., & Brenner, D. A. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.01.030 · Cited by 214 · see citing works

Tumor Necrosis Factor-induced Toxic Liver Injury Results from JNK2-dependent Activation of Caspase-8 and the Mitochondrial Death Pathway

Wang, Y., Singh, R., Lefkowitch, J. H., Rigoli, R. M., & Czaja, M. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512953200 · Cited by 206 · see citing works

JNK signaling pathway required for wound healing in regenerating Drosophila wing imaginal discs

Bosch, M., Serras, F., Martı́n-Blanco, E., & Baguñà, J. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.01.002 · Cited by 197 · see citing works

c-Jun N-terminal Kinase-1 From Hematopoietic Cells Mediates Progression From Hepatic Steatosis to Steatohepatitis and Fibrosis in Mice

Kodama, Y., Kisseleva, T., Iwaisako, K., Miura, K., Taura, K., Minicis, S. D., Österreicher, C. H., Schnabl, B., Seki, E., & Brenner, D. A. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.06.045 · Cited by 195 · see citing works

Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure

Henderson, N. C., Pollock, K. J., Frew, J. W., MacKinnon, A. C., Flavell, R. A., Davis, R. J., Sethi, T., & Simpson, K. J. (2006) · Gut · doi:10.1136/gut.2006.104372 · Cited by 182 · see citing works

A Pathogenic Role for c-Jun Amino-Terminal Kinase Signaling in Renal Fibrosis and Tubular Cell Apoptosis

Ma, F. Y., Flanc, R. S., Tesch, G. H., Han, Y., Atkins, R. C., Bennett, B. L., Friedman, G. C., Fan, J.-H., & Nikolic‐Paterson, D. J. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006060604 · Cited by 180 · see citing works

Transforming Growth Factor-β and Platelet-Derived Growth Factor Signal via c-Jun N-Terminal Kinase-Dependent Smad2/3 Phosphorylation in Rat Hepatic Stellate Cells after Acute Liver Injury

Yoshida, K., Matsuzaki, K., Mori, S., Tahashi, Y., Yamagata, H., Furukawa, F., Seki, T., Nishizawa, M., Fujisawa, J., & Okazaki, K. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62324-3 · Cited by 165 · see citing works

Differential requirement for c‐Jun NH 2 ‐terminal kinase in TNF‐α‐and Fas‐mediated apoptosis in hepatocytes

Schwabe, R. F., Uchinami, H., Qian, T., Bennett, B. L., Lemasters, J. J., & Brenner, D. A. (2004) · The FASEB Journal · doi:10.1096/fj.03-0771fje · Cited by 141 · see citing works

Disruption of Basal JNK Activity Differentially Affects Key Fibroblast Functions Important for Wound Healing

Javelaud, D., Laboureau, J., Gabison, E. E., Verrecchia, F., & Mauviel, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301942200 · Cited by 137 · see citing works

TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells

Schnabl, B., Bradham, C. A., Bennett, B. L., Manning, A. M., Stefanovic, B., & Brenner, D. A. (2001) · Hepatology · doi:10.1053/jhep.2001.28790 · Cited by 129 · see citing works

Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-β1

Alcorn, J. F., Guala, A. S., van der Velden, J. L. J., McElhinney, B., Irvin, C. G., Davis, R. J., & Janssen-Heininger, Y. M. W. (2008) · Journal of Cell Science · doi:10.1242/jcs.019455 · Cited by 128 · see citing works

Angiotensin II Activates IκB Kinase Phosphorylation of RelA at Ser536 to Promote Myofibroblast Survival and Liver Fibrosis

Oakley, F., Teoh, V. W. Y., Ching-A-Sue, G., Bataller, R. A., Colmenero, J., Jonsson, J. R., Eliopoulos, A. G., Watson, M. R., Manas, D., & Mann, D. A. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.081 · Cited by 127 · see citing works

Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C

Colmenero, J., Bataller, R. A., Sancho‐Bru, P., Domínguez, M., Moreno, M., Forns, X., Bruguera, M., Arroyo, V., Brenner, D. A., & Ginès, P. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00162.2009 · Cited by 117 · see citing works

c-Jun N-Terminal Kinase 1 Is Required for the Development of Pulmonary Fibrosis

Alcorn, J. F., van der Velden, J. L. J., Brown, A. L., McElhinney, B., Irvin, C. G., & Janssen-Heininger, Y. M. W. (2008) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0174oc · Cited by 102 · see citing works

Role of Jun N-terminal Kinase (JNK) signaling in the wound healing and regeneration of a Drosophila melanogaster wing imaginal disc

Mattila, J., Omelyanchuk, L. V., Kyttala, S., Turunen, H., & Nokkala, S. (2005) · The International Journal of Developmental Biology · doi:10.1387/ijdb.052006jm · Cited by 100 · see citing works

Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease

Toivola, D. M., Ku, N., Resurreccion, E. Z., et al. (2004) · Hepatology · doi:10.1002/hep.20277 · Cited by 85 · see citing works

IKKβ phosphorylates p65 at S468 in transactivaton domain 2

Schwabe, R. F., & Sakurai, H. (2005) · The FASEB Journal · doi:10.1096/fj.05-3736fje · Cited by 84 · see citing works

JNK2 mediates TNF-induced cell death in mouse embryonic fibroblasts via regulation of both caspase and cathepsin protease pathways

Dietrich, N. L., Thastrup, J., Holmberg, C., Gyrd‐Hansen, M., Fehrenbacher, N., Lademann, U. A., Lerdrup, M., Herdegen, T., Jäättelä, M., & Kallunki, T. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401353 · Cited by 64 · see citing works

Regulation of ERK/JNK/p70S6K in two rat models of liver injury and fibrosis

Svegliati‐Baroni, G., Ridolfi, F., Caradonna, Z., Alvaro, D., Marzioni, M., Saccomanno, S., Candelaresi, C., Trozzi, L., Macarri, G., Benedetti, A., et al. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(03)00291-5 · Cited by 61 · see citing works

JunD is a profibrogenic transcription factor regulated by Jun N-terminal kinase-independent phosphorylation

Smart, D. E., Green, K., Oakley, F., Weitzman, J. B., Yaniv, M., Reynolds, G. M., Mann, J., Millward‐Sadler, H., & Mann, D. A. (2006) · Hepatology · doi:10.1002/hep.21436 · Cited by 52 · see citing works

Divergent Transforming Growth Factor-β Signaling in Hepatic Stellate Cells after Liver Injury

Khimji, A.-K., Shao, R., & Rockey, D. C. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.071121 · Cited by 27 · see citing works

AT1A-mediated activation of kidney JNK1 and SMAD2 in obstructive uropathy: preservation of kidney tissue mass using candesartan

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Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4

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NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

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Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy

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Hepatic inflammation and fibrosis: Functional links and key pathways

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Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice

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Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice

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p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling

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Alcoholic liver disease: pathogenesis and new targets for therapy

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The PNPLA3 I148M variant modulates the fibrogenic phenotype of human hepatic stellate cells

Bruschi, F. V., Claudel, T., Tardelli, M., Caligiuri, A., Stulnig, T. M., Marra, F., & Trauner, M. (2017) · Hepatology · doi:10.1002/hep.29041 · Cited by 268 · see citing works

Liver fibrosis: from basic science towards clinical progress, focusing on the central role of hepatic stellate cells

Akkız, H., Gieseler, R. K., & Canbay, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147873 · Cited by 191 · see citing works

IL-17A enhances the expression of profibrotic genes through upregulation of the TGF-β receptor on hepatic stellate cells in a JNK-dependent manner

Fabre, T., Kared, H., Friedman, S. L., & Shoukry, N. H. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400861 · Cited by 150 · see citing works

Myeloperoxidase–Hepatocyte–Stellate Cell Cross Talk Promotes Hepatocyte Injury and Fibrosis in Experimental Nonalcoholic Steatohepatitis

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TREM2 Regulates the Removal of Apoptotic Cells and Inflammatory Processes during the Progression of NAFLD

Liebold, I., Meyer, S., Heine, M., Kuhl, A., Witt, J., Eissing, L., Fischer, A., Koop, A., Kluwe, J., Schulze zur Wiesch, J., et al. (2023) · Cells · doi:10.3390/cells12030341 · Cited by 55 · see citing works

Research progress on the relationship between transforming growth factor-β1 and hepatic fibrosis

Li, S., & Wang, A. (2017) · Zhonghua shiyan waike zazhi · doi:10.3760/cma.j.issn.1001-9030.2017.06.063

Effectiveness of saponins from Panax notoginseng against hepatic fibrosis

Li, H. (2007) · Zhongguo xin yao zazhi

A Selective PPARγ Modulator Reduces Hepatic Fibrosis

McVicker, B. L., Hamel, F. G., Simpson, R. L., & Bennett, R. G. (2020) · Biology · doi:10.3390/biology9070151 · Cited by 8 · see citing works

Non-Invasively Distinguishing Progress of Liver Fibrosis by Visualizing Hepatic Platelet Derived Growth Factor Receptor-Beta Expression with an MRI Modality in MicePreprint

Wu, L., Huang, X., Li, N., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-53243/v1 · Cited by 1 · see citing works

Hepatic fibrosis: It is time to go with hepatic stellate cell-specific therapeutic targets

Ezhilarasan, D., Sokal, E., & Najimi, M. (2018) · Hepatobiliary & Pancreatic Diseases International · doi:10.1016/j.hbpd.2018.04.003 · Cited by 204 · see citing works