Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice
Open accessAbstract
Background & aims Activated hepatic stellate cells (HSCs), the main fibrogenic cell type in the liver, undergo apoptosis after cessation of liver injury, which contributes to resolution of fibrosis. In this study, we investigated whether HSC deactivation constitutes an additional mechanism of liver fibrosis resolution.Methods HSC activation and deactivation were investigated by single-cell PCR and genetic tracking in transgenic mice that expressed a tamoxifen-inducible CreER under control of the endogenous vimentin promoter (Vimentin-CreER).Results Single-cell quantitative polymerase chain reaction demonstrated activation of almost the entire HSC population in fibrotic livers, and a gradual decrease of HSC activation during fibrosis resolution, indicating deactivation of HSCs. Vimentin-CreER marked activated HSCs, demonstrated by a 6- to 16-fold induction of a membrane-bound green fluorescent protein (mGFP) Cre-reporter after injection of carbon tetrachloride, in liver and isolated HSCs, and a shift in localization of mGFP-marked HSCs from peri-sinusoidal to fibrotic septa. Tracking of mGFP-positive HSCs revealed the persistence of 40%-45% of mGFP expression in livers and isolated HSCs 30-45 days after carbon tetrachloride was no longer administered, despite normalization of fibrogenesis parameters; these findings confirm reversal of HSC activation. After fibrosis resolution, mGFP expression was observed again in desmin-positive peri-sinusoidal HSCs; no mGFP expression was detected in hepatocytes or cholangiocytes, excluding mesenchymal-epithelial transition. Notably, reverted HSCs remained in a primed state, with higher levels of responsiveness to fibrogenic stimuli.Conclusions In mice, reversal of HSC activation contributes to termination of fibrogenesis during fibrosis resolution, but results in higher responsiveness of reverted HSCs to recurring fibrogenic stimulation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Restored RSPO3 expression during HSC deactivation or by therapeutic interventions might help to regain hepatocyte functions.
“Conversely, restored RSPO3 expression during HSC deactivation52,53 or by therapeutic interventions might help to regain hepatocyte functions.”
From Hepatic stellate cells control liver zonation, size and functions via R-spondin 3 (2025) · cites this paper as [53]
Most myofibroblasts in chemically injured mouse models come from HSCs, and depleting them reduces liver fibrosis.
“The majority of myofibroblasts in chemically-injured mouse models also derive from HSCs, and their depletion reduces liver fibrosis (52-54).”
From Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH) (2023) · cites this paper as [52]
Other myofibroblast sources include vascular smooth muscle cells, mesothelial cells, and portal fibroblasts; portal myofibroblasts marked by THY1 may play an outsized role in biliary fibrosis because of their portal location.
“Other sources of myofibroblasts include vascular smooth muscle cells, mesothelial cells, and portal fibroblasts, out of which portal myofibroblasts marked by thymocyte differentiation antigen 1 (THY1) may play an outsized role in biliary fibrosis due to their physical localization in the portal region (53, 55-57) (58).”
From Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH) (2023) · cites this paper as [55]
Animal models reinforce the capacity of injured liver to regress fibrosis and provide a platform for dissecting mechanisms, although mouse fibrosis regresses rapidly, possibly due to short model duration and young age.
“Animal models reinforce the capacity of the injured liver to regress fibrosis and provide important platform for dissecting underlying mechanisms, although it should be noted that fibrosis in mice regresses incredibly rapidly, which may be in part attributed to the short duration of models (weeks to months in mice vs. years to decades in humans) and initiation of fibrosis at relatively young age (”
From Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH) (2023) · cites this paper as [52]
Animal models implicate HSCs and immune cells, especially macrophages, as major cellular drivers of extracellular matrix turnover, through reduced secretion of ECM components and crosslinking enzymes and increased secretion of proteases and their inhibitors.
“Animal models implicate HSCs and immune cells, especially macrophages, as major cellular drivers of extracellular matrix turnover, both through reduced secretion of ECM components and crosslinking enzymes as well as increased secretion of proteases and their inhibitors (51, 52, 64, 262, 270-274).”
From Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH) (2023) · cites this paper as [52]
Fibroblast activation involves increased activity of key glycolytic enzymes such as hexokinase 2 and lactate dehydrogenase, which increase cell proliferation and collagen synthesis.
“Fibroblast activation also involves increased activity of key glycolytic enzymes, such as hexokinase 2 and lactate dehydrogenase (LDH)47, which in turn increase cell proliferation47 and collagen synthesis48.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [48]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works
Bioconductor: open software development for computational biology and bioinformatics
Gentleman, R., Carey, V., Bates, D., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge, Y., Gentry, J., et al. (2004) · Genome Biology · doi:10.1186/gb-2004-5-10-r80 · Cited by 13,133 · see citing works
Smyth, G. K. (2004) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1027 · Cited by 11,829 · see citing works
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Irizarry, R. A. (2003) · Biostatistics · doi:10.1093/biostatistics/4.2.249 · Cited by 10,603 · see citing works
Everitt, B. J., Landau, S., & Leese, M. (1974) · Cited by 9,186 · see citing works
Bataller, R., & Brenner, D. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24282 · Cited by 4,958 · see citing works
A global double-fluorescent Cre reporter mouse
Muzumdar, M. D., Tasic, B., Miyamichi, K., Li, L., & Luo, L. (2007) · genesis · doi:10.1002/dvg.20335 · Cited by 3,491 · see citing works
Open source clustering software
de Hoon, M., Imoto, S., Nolan, J., & Miyano, S. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth078 · Cited by 3,043 · see citing works
Java Treeview—extensible visualization of microarray data
Saldanha, A. J. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth349 · Cited by 2,991 · see citing works
Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver
Friedman, S. L. (2008) · Physiological Reviews · doi:10.1152/physrev.00013.2007 · Cited by 2,842 · see citing works
TLR4 enhances TGF-β signaling and hepatic fibrosis
Seki, E., De Minicis, S., Österreicher, C. H., Kluwe, J., Osawa, Y., Brenner, D. A., & Schwabe, R. F. (2007) · Nature Medicine · doi:10.1038/nm1663 · Cited by 1,942 · see citing works
Self-citationVimentin in cancer and its potential as a molecular target for cancer therapy
Satelli, A., & Li, S. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0735-1 · Cited by 1,557 · see citing works
Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis
Humphreys, B. D., Lin, S., Kobayashi, A., Hudson, T. E., Nowlin, B. T., Bonventre, J. V., Valerius, M. T., McMahon, A. P., & Duffield, J. S. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090517 · Cited by 1,447 · see citing works
Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4
Dapito, D. H., Mencin, A., Gwak, G.-Y., Pradere, J.-P., Jang, M.-K., Mederacke, I., Caviglia, J. M., Khiabanian, H., Adeyemi, A., Bataller, R., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.007 · Cited by 1,346 · see citing works
Self-citationPoynard, T., McHutchison, J. G., Manns, M. P., TREPO, C. G., Lindsay, K. L., Goodman, Z. D., Ling, M.-H., & Albrecht, J. K. (2002) · Gastroenterology · doi:10.1053/gast.2002.33023 · Cited by 1,141 · see citing works
Iredale, J. P., Benyon, R. C., Pickering, J., McCullen, M., Northrop, M., Pawley, S., Hovell, C., & Arthur, M. J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1018 · Cited by 1,075 · see citing works
Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis
Kisseleva, T., Cong, M., Paik, Y., Scholten, D., Jiang, C., Benner, C., Iwaisako, K., Moore-Morris, T., Scott, B., Tsukamoto, H., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201840109 · Cited by 805 · see citing works
Nonalcoholic fatty liver disease: Improvement in liver histological analysis with weight loss
Dixon, J. B., Bhathal, P. S., Hughes, N. R., & O'Brien, P. E. (2004) · Hepatology · doi:10.1002/hep.20251 · Cited by 727 · see citing works
Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis
Georges, P. C., Hui, J.-J., Gombos, Z., McCormick, M. E., Wang, A. Y., Uemura, M., Mick, R., Janmey, P. A., Furth, E. E., & Wells, R. G. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00032.2007 · Cited by 577 · see citing works
Issa, R., Zhou, X., Constandinou, C. M., Fallowfield, J. A., Millward‐Sadler, H., Gaça, M. D. A., Sands, E., Suliman, I., Trim, N., & Knorr, A. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.03.009 · Cited by 455 · see citing works
CCR1 and CCR5 promote hepatic fibrosis in mice
Seki, E., De Minicis, S., Gwak, G.-Y., Kluwe, J., Inokuchi, S., Bursill, C. A., Llovet, J. M., Brenner, D. A., & Schwabe, R. F. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37444 · Cited by 431 · see citing works
Self-citationHammel, P., Couvelard, A., O'Toole, D., Ratouis, A., Sauvanet, A., Fléjou, J. F., Degott, C., Belghiti, J., Bernades, P., Valla, D., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102083440604 · Cited by 427 · see citing works
Wright, M. C., Issa, R., Smart, D. E., Trim, N., Murray, G. I., Primrose, J. M., Arthur, M. J. P., Iredale, J. P., & Mann, D. A. (2001) · Gastroenterology · doi:10.1053/gast.2001.27188 · Cited by 356 · see citing works
Hepatic stellate cells require a stiff environment for myofibroblastic differentiation
Olsen, A. L., Bloomer, S. A., Chan, E. P., Gaça, M. D. A., Georges, P. C., Sackey, B., Uemura, M., Janmey, P. A., & Wells, R. G. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00412.2010 · Cited by 355 · see citing works
Purified Rat Liver Fat-Storing Cells in Culture Divide and Contain Collagen
Leeuw, A. D. M., McCarthy, S. P., Geerts, A. E., & Knook, D. L. (1984) · Hepatology · doi:10.1002/hep.1840040307 · Cited by 325 · see citing works
Farci, P., Roskams, T., Chessa, L., Peddis, G., Mazzoleni, A. P., Scioscia, R., Serra, G., Lai, M. E., Loy, M., & Caruso, L. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.03.017 · Cited by 293 · see citing works
Scholten, D., Österreicher, C. H., Scholten, A., Iwaisako, K., Gu, G., Brenner, D. A., & Kisseleva, T. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.05.005 · Cited by 225 · see citing works
Modulation of Hepatic Fibrosis by c-Jun-N-Terminal Kinase Inhibition
Kluwe, J., Pradere, J., Gwak, G., Mencin, A., De Minicis, S., Österreicher, C. H., Colmenero, J., Bataller, R., & Schwabe, R. F. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.09.015 · Cited by 217 · see citing works
Self-citationChemokines in liver inflammation and fibrosis
Marra, F. (2002) · Frontiers in bioscience · doi:10.2741/a887 · Cited by 214 · see citing works
Fate-Mapping Evidence That Hepatic Stellate Cells Are Epithelial Progenitors in Adult Mouse Livers
Yang, L., Jung, Y., Omenetti, A., Witek, R. P., Choi, S. S., VanDongen, H. M. A., Huang, J., Alpini, G. D., & Diehl, A. M. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0115 · Cited by 200 · see citing works
Kweon, Y.-O., Goodman, Z. D., Dienstag, J. L., Schiff, E. R., Brown, N. A., Burkhardt, E., Schoonhoven, R., Brenner, D. A., & Fried, M. W. (2001) · Journal of Hepatology · doi:10.1016/s0168-8278(01)00218-5 · Cited by 168 · see citing works
Chemokines in Liver Inflammation and Fibrosis
Wasmuth, H. E., Tacke, F., & Trautwein, C. (2010) · Seminars in Liver Disease · doi:10.1055/s-0030-1255351 · Cited by 159 · see citing works
Popov, Y. V., Sverdlov, D., Sharma, A. K., Bhaskar, K. R., Li, S., Freitag, T. L., Lee, J. D., Dieterich, W., Melino, G., & Schuppan, D. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.040 · Cited by 137 · see citing works
TFF2 mRNA Transcript Expression Marks a Gland Progenitor Cell of the Gastric Oxyntic Mucosa
Quante, M., Marrache, F., Goldenring, J. R., & Wang, T. C. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.08.003 · Cited by 125 · see citing works
Reversibility of hepatic fibrosis in experimentally induced cholestasis in rat.
Abdelaziz, G., Lebeau, G., Rescan, P., Clément, B., Rissel, M., Deugnier, Y., Campion, J. P., & Guillouzo, A. (1990) · Europe PMC (PubMed Central) · Cited by 124 · see citing works
Kluwe, J., Wongsiriroj, N., Troeger, J. S., Gwak, G., Dapito, D. H., Pradère, J., Jiang, H., Siddiqi, M., Piantedosi, R., O’Byrne, S. M., et al. (2011) · Gut · doi:10.1136/gut.2010.209551 · Cited by 121 · see citing works
Self-citationReversibility of Cirrhosis in Patients Cured of Thalassemia by Bone Marrow Transplantation
Muretto, P., Angelucci, E., & Lucarelli, G. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-136-9-200205070-00009 · Cited by 101 · see citing works
Genomic and functional characterization of stellate cells isolated from human cirrhotic livers
Sancho‐Bru, P., Bataller, R. A., Gasull, X., Colmenero, J., Khurdayan, V. K., Gual, A., Nicolás, J. M., Arroyo, V., & Ginès, P. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.02.035 · Cited by 85 · see citing works
Rossen, E. V., Borght, S. V., van Grunsven, L. A., Reynaert, H., Bruggeman, V., Blomhoff, R., Roskams, T., & Geerts, A. E. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0544-2 · Cited by 53 · see citing works
Reversal of hepatic fibrosis after praziquantel therapy of murine schistosomiasis
Morcos, S. H., Khayyal, M. T., Saleh, S., Dunn, M. A., Mansour, M. M., Girgis, N. I., & Ishak, E. A. (1985) · The American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1985.34.314 · Cited by 46 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Molecular and cellular mechanisms of liver fibrosis and its regression
Kisseleva, T., & Brenner, D. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00372-7 · Cited by 2,024 · see citing works
Fibrosis: from mechanisms to medicines
Henderson, N. C., Rieder, F., & Wynn, T. A. (2020) · Nature · doi:10.1038/s41586-020-2938-9 · Cited by 1,868 · see citing works
Fischer, K. R., Durrans, A., Lee, S., Sheng, J., Li, F., Wong, S. T. C., Choi, H., El Rayes, T., Ryu, S., Troeger, J., et al. (2015) · Nature · doi:10.1038/nature15748 · Cited by 1,791 · see citing works
Self-citationMederacke, I., Hsu, C. C., Troeger, J. S., Huebener, P., Mu, X., Dapito, D. H., Pradere, J.-P., & Schwabe, R. F. (2013) · Nature Communications · doi:10.1038/ncomms3823 · Cited by 1,443 · see citing works
Self-citationLiver fibrosis and repair: Immune regulation of wound healing in a solid organ
Pellicoro, A., Ramachandran, P., Iredale, J. P., & Fallowfield, J. A. (2014) · Nature Reviews Immunology · doi:10.1038/nri3623 · Cited by 1,310 · see citing works
Roles for chemokines in liver disease
Marra, F., & Tacke, F. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.06.043 · Cited by 829 · see citing works
Hepatic inflammatory responses in liver fibrosis
Hammerich, L., & Tacke, F. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00807-x · Cited by 803 · see citing works
Mechanisms of Fibrosis Development in Nonalcoholic Steatohepatitis
Schwabe, R. F., Tabas, I., & Pajvani, U. B. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.11.311 · Cited by 671 · see citing works
Self-citationTherapy for Fibrotic Diseases: Nearing the Starting Line
Friedman, S. L., Sheppard, D., Duffield, J. S., & Violette, S. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3004700 · Cited by 655 · see citing works
Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis
Ding, B.-S., Cao, Z., Lis, R., Nolan, D. J., Guo, P., Simons, M., Penfold, M. E., Shido, K., Rabbany, S. Y., & Rafii, S. (2014) · Nature · doi:10.1038/nature12681 · Cited by 626 · see citing works
Determinants of Fibrosis Progression and Regression in NASH
Schuppan, D., Surabattula, R., & Wang, X. Y. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2017.11.012 · Cited by 479 · see citing works
The Power of Plasticity—Metabolic Regulation of Hepatic Stellate Cells
Trivedi, P., Wang, S., & Friedman, S. L. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.10.026 · Cited by 427 · see citing works
Hinz, B. (2016) · Experimental Eye Research · doi:10.1016/j.exer.2015.07.009 · Cited by 424 · see citing works
The big five in fibrosis: Macrophages, myofibroblasts, matrix, mechanics, and miscommunication
Pakshir, P., & Hinz, B. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.019 · Cited by 396 · see citing works
Liver regeneration and inflammation: from fundamental science to clinical applications
Campana, L., Esser, H., Huch, M., & Forbes, S. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00373-7 · Cited by 307 · see citing works
Kim, K.-H., Chen, C.-C., Monzon, R. I., & Lau, L. F. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00049-13 · Cited by 261 · see citing works
Cellular Mechanisms of Liver Fibrosis
Acharya, P., Chouhan, K., Weiskirchen, S., & Weiskirchen, R. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.671640 · Cited by 252 · see citing works
Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis
Lagares, D., Santos, A., Grasberger, P. E., Liu, F., Probst, C. K., Rahimi, R. A., Sakai, N., Kuehl, T., Ryan, J., Bhola, P., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aal3765 · Cited by 246 · see citing works
Bates, J., Vijayakumar, A., Ghoshal, S., Marchand, B., Yi, S., Kornyeyev, D., Zagorska, A., Hollenback, D., Walker, K., Liu, K., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.04.037 · Cited by 230 · see citing works
The spatiotemporal program of zonal liver regeneration following acute injury
Ben-Moshe, S., Veg, T., Manco, R., Dan, S., Papinutti, D., Lifshitz, A., Kolodziejczyk, A. A., Bahar Halpern, K., Elinav, E., & Itzkovitz, S. (2022) · Cell Stem Cell · doi:10.1016/j.stem.2022.04.008 · Cited by 224 · see citing works
Cellular mechanisms of tissue fibrosis. 5. Novel insights into liver fibrosis
Mallat, A., & Lotersztajn, S. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00230.2013 · Cited by 211 · see citing works
Akkız, H., Gieseler, R. K., & Canbay, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147873 · Cited by 191 · see citing works
Protein neddylation and its role in health and diseases
Zhang, S., Yu, Q., Li, Z., Zhao, Y., & Sun, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01800-9 · Cited by 171 · see citing works
Single-cell RNA sequencing of human liver reveals hepatic stellate cell heterogeneity
Payen, V. L., Lavergne, A., Alevra Sarika, N., Colonval, M., Karim, L., Deckers, M., Najimi, M., Coppieters, W., Charloteaux, B., Sokal, E. M., et al. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100278 · Cited by 160 · see citing works
Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH)
Wang, S., & Friedman, S. L. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adi0759 · Cited by 158 · see citing works
Inzaugarat, M. E., Johnson, C. D., Holtmann, T. M., McGeough, M. D., Trautwein, C., Papouchado, B. G., Schwabe, R., Hoffman, H. M., Wree, A., & Feldstein, A. E. (2019) · Hepatology · doi:10.1002/hep.30252 · Cited by 148 · see citing works
Self-citationHepatic stellate cells control liver zonation, size and functions via R-spondin 3
Sugimoto, A., Saito, Y., Wang, G., Sun, Q., Yin, C., Lee, K. H., Geng, Y., Rajbhandari, P., Hernandez, C., Steffani, M., et al. (2025) · Nature · doi:10.1038/s41586-025-08677-w · Cited by 110 · see citing works
Self-citationPharmacological intervention in hepatic stellate cell activation and hepatic fibrosis
Schon, H.-T., Bartneck, M., Borkham-Kamphorst, E., Nattermann, J., Lammers, T., Tacke, F., & Weiskirchen, R. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00033 · Cited by 97 · see citing works
Huang, Y.-H., Chen, M.-H., Guo, Q.-L., Chen, Z.-X., Chen, Q.-D., & Wang, X.-Z. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2019.109445 · Cited by 90 · see citing works
Hepatic Stellate Cells and Liver Fibrosis
Puche, J. E., Saiman, Y., & Friedman, S. L. (2013) · Comprehensive Physiology · doi:10.1002/j.2040-4603.2013.tb00529.x · Cited by 89 · see citing works
Nakano, Y., Kamiya, A., Sumiyoshi, H., Tsuruya, K., Kagawa, T., & Inagaki, Y. (2020) · Hepatology · doi:10.1002/hep.30965 · Cited by 86 · see citing works
Hepatic Stellate Cells: Dictating Outcome in Nonalcoholic Fatty Liver Disease
Wiering, L., Subramanian, P., & Hammerich, L. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.02.010 · Cited by 80 · see citing works
Initiation of hepatic stellate cell activation extends into chronic liver disease
De Smet, V., Eysackers, N., Merens, V., Kazemzadeh Dastjerd, M., Halder, G., Verhulst, S., Mannaerts, I., & van Grunsven, L. A. (2021) · Cell Death & Disease · doi:10.1038/s41419-021-04377-1 · Cited by 78 · see citing works
The Origin and Fate of Liver Myofibroblasts
Kim, H. Y., Sakane, S., Eguileor, A., Carvalho Gontijo Weber, R., Lee, W., Liu, X., Lam, K., Ishizuka, K., Rosenthal, S. B., Diggle, K., et al. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.09.008 · Cited by 63 · see citing works
Hepatic fibrosis: A convergent response to liver injury that is reversible
Wang, S., & Friedman, S. L. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.03.011 · Cited by 62 · see citing works
GATA4 induces liver fibrosis regression by deactivating hepatic stellate cells
Arroyo, N., Villamayor, L., Díaz, I., Carmona, R., Ramos-Rodríguez, M., Muñoz-Chápuli, R., Pasquali, L., Toscano, M. G., Martín, F., Cano, D. A., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.150059 · Cited by 60 · see citing works
Yang, J., Lu, Y., Yang, P., Chen, Q., Wang, Y., Ding, Q., Xu, T., Li, X., Li, C., Huang, C., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.27521 · Cited by 40 · see citing works
Katsumata, L. W., Miyajima, A., & Itoh, T. (2017) · Hepatology Communications · doi:10.1002/hep4.1023 · Cited by 38 · see citing works
Wilson, C. L., Mann, J., Walsh, M., Perrugoria, M. J., Oakley, F., Wright, M. C., Brignole, C., Di Paolo, D., Perri, P., Ponzoni, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0083391 · Cited by 31 · see citing works
Future mechanistic strategies for tackling fibrosis–an unmet need in liver disease
Fallowfield, J. A. (2015) · Clinical Medicine · doi:10.7861/clinmedicine.15-6-s83 · Cited by 15 · see citing works
Jia, H., Ding, L., Yu, A., Tang, W., Tang, S., Zhang, C., & Oupický, D. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.07.018 · Cited by 12 · see citing works
- Authors
- Troeger, J. S., Mederacke, I., Gwak, G., Dapito, D. H., Mu, X., Hsu, C. C., Pradere, J., Friedman, R. A., & Schwabe, R. F.
- Affiliations
- Columbia University (US)
- Herbert Irving Comprehensive Cancer Center (US)
- Corresponding author
- Schwabe, Robert F.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 143
- Issue
- 4
- Pages
- 1073-1083.e22
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC3848328
- OpenAlex
- W2163036793
- Cited by
- 515
- References
- 40
- Citations by year
- 2026: 21 · 2025: 40 · 2024: 36 · 2023: 31 · 2022: 31 · 2021: 37 · 2020: 48 · 2019: 34 · 2018: 40 · 2017: 38 · 2016: 44 · 2015: 45 · 2014: 40 · 2013: 24 · 2012: 3
- FWCI
- 22.69
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (1F31DK091980, ME 3723/1-1)
- American Liver Foundation
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Keywords
- hepatic stellate cells, liver fibrosis, fibrosis resolution, stellate cell activation, apoptosis, carbon tetrachloride-induced liver injury, single-cell PCR, desmin
- MeSH terms
- Collagen Type I, alpha 1 Chain, Actins, Animals, Carbon Tetrachloride, Cells, Cultured, Genetic Techniques, Genotype, Liver Cirrhosis, Male, Mice, Transgenic, Platelet-Derived Growth Factor, RNA, Messenger, Tamoxifen, Vimentin, Biomarkers, Gene Expression, Polymerase Chain Reaction, Transforming Growth Factor beta, Integrases, Collagen Type I, Green Fluorescent Proteins, Mice, Hepatic Stellate Cells, Myofibroblasts
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
