The Receptor TGR5 Mediates the Prokinetic Actions of Intestinal Bile Acids and Is Required for Normal Defecation in Mice

Alemi, Farzad, Poole, Daniel P., Chiu, Jonathan, Schoonjans, Kristina, Cattaruzza, Fiore, Grider, John R., Bunnett, Nigel W., Corvera, Carlos U.·2013·Gastroenterology

DOI 10.1053/j.gastro.2012.09.055

Cited by (360)

Items 101–200 of 360

Analysis of Fecal Primary Bile Acids Detects Increased Stool Weight and Colonic Transit in Patients With Chronic Functional Diarrhea
Priya Vijayvargiya, Michael Camilleri, Victor G Chedid, Paula Carlson, Irene A. Busciglio, Duane D. Burton, Leslie J. Donato · 2018 · Clinical Gastroenterology and Hepatology
Gut microbiota alteration after cholecystectomy contributes to post-cholecystectomy diarrhea via bile acids stimulating colonic serotonin
Xu, Yayun, Wang, Jianfa, Wu, Xubo, Jing, Hui, Zhang, Shilong, Hu, Zhiqiu, Rao, Longhua, Chang, Qimeng, Wang, Lishun, Zhang, Ziping · 2023 · Gut Microbes
Genetic variation in GPBAR1 predisposes to quantitative changes in colonic transit and bile acid excretion
Michael Camilleri, Andrea Shin, Irene A. Busciglio, Paula Carlson, Andres J Acosta, Adil E. Bharucha, Duane B. Burton, Jesse Lamsam, Alan J. Lueke, Leslie J. Donato et al. · 2014 · American Journal of Physiology-Gastrointestinal and Liver Physiology
Gut Microbiota and Relevant Metabolites Analysis in Alcohol Dependent Mice
Guanhao Wang, Qing Liu, Liang Guo, Haijuan Zeng, Chengchao Ding, Wentong Zhang, Dongpo Xu, Xiang Wang, Jingxuan Qiu, Qingli Dong et al. · 2018 · Frontiers in Microbiology
Enterochromaffin Cells–Gut Microbiota Crosstalk: Underpinning the Symptoms, Pathogenesis, and Pharmacotherapy in Disorders of Gut-Brain Interaction
Lai Wei, Rajan Singh, Uday C. Ghoshal · 2022 · Journal of Neurogastroenterology and Motility
Obesity diabetes and the role of bile acids in metabolism
GERALD H. TOMKIN, Daphne Owens · 2016 · Journal of Translational Internal Medicine
The contribution of bile acid metabolism to the pathogenesis of Clostridioides difficile infection
Benjamin Harvey Mullish, Jessica Ravikoff Allegretti · 2021 · Therapeutic Advances in Gastroenterology
Bile Acid and Gut Microbiota in Irritable Bowel Syndrome
Yang Won Min, Ali Ranjideh Rezaie, Mark Pimentel · 2022 · Journal of Neurogastroenterology and Motility
Chronic diarrhoea following surgery for colon cancer—frequency, causes and treatment options
Jonathan Yde, Helene Mathilde Larsen, Søren Laurberg, Klaus Krogh, Hanne B. Moeller · 2018 · International Journal of Colorectal Disease
Bile Acid-Related Regulation of Mucosal Inflammation and Intestinal Motility: From Pathogenesis to Therapeutic Application in IBD and Microscopic Colitis
Federica Di Vincenzo, Pierluigi Puca, Loris Riccardo Lopetuso, Valentina Petito, Letizia Masi, Bianca Bartocci, Marco Murgiano, Margherita De Felice, Lorenzo Petronio, Antonio Gasbarrini et al. · 2022 · Nutrients
Decoding the vasoregulatory activities of bile acid-activated receptors in systemic and portal circulation: role of gaseous mediators
Stefano Fiorucci, Angela Zampella, Giuseppe Cirino, Mariarosaria Bucci, Eleonora Distrutti · 2016 · American Journal of Physiology-Heart and Circulatory Physiology
Colonic Transit and Bile Acid Synthesis or Excretion in Patients With Irritable Bowel Syndrome–Diarrhea Without Bile Acid Malabsorption
Cédric Peleman, Michael Camilleri, Irene A. Busciglio, Duane D. Burton, Leslie J. Donato, Alan R. Zinsmeister · 2016 · Clinical Gastroenterology and Hepatology
Host-Gut Microbiota Crosstalk in Intestinal Adaptation
Justine Marchix, Gillian R. Goddard, Michael A. Helmrath · 2018 · Cellular and Molecular Gastroenterology and Hepatology
Different Bifidobacterium bifidum strains change the intestinal flora composition of mice via different mechanisms to alleviate loperamide-induced constipation
Mao Chai, Linlin Wang, Xinping Li, Jianxin Zhao, Hao Zhang, Gang Wang, Wei Chen · 2021 · Food & Function
Bile Acid Signaling in Inflammatory Bowel Disease
Mariusz A. Bromke, Małgorzata Krzystek‐Korpacka · 2021 · International Journal of Molecular Sciences
The bile acid receptor, TGR 5, regulates basal and cholinergic‐induced secretory responses in rat colon
Joseph B. J. Ward, Magdalena Slawa Mroz, Stephen J. Keely · 2013 · Neurogastroenterology & Motility
TGR5: Pathogenetic Role and/or Therapeutic Target in Fibrosing Cholangitis?
Verena Keitel, Maria Reich, Dieter Häussinger · 2014 · Clinical Reviews in Allergy & Immunology
Modulating bile acid pathways and TGR5 receptors for treating liver and GI diseases
Harmeet Malhi, Michael Camilleri · 2017 · Current Opinion in Pharmacology
Bile acids: Key players in inflammatory bowel diseases?
Kriaa, Aicha, Mariaule, Vincent, Jablaoui, Amin, Rhimi, Soufien, Mkaouar, Hela, Hernandez, Juan, Korkmaz, Brice, Lesner, Adam, Maguin, Emmanuelle, Aghdassi, Ali et al. · 2022 · Cells
Bile Acid Sequestrants: Glucose-Lowering Mechanisms and Efficacy in Type 2 Diabetes
Morten Hansen, David Peick Sonne, Filip Krag Knop · 2014 · Current Diabetes Reports
Abnormal bile acid metabolism is an important feature of gut microbiota and fecal metabolites in patients with slow transit constipation
Yadong Fan, Chen Xu, Lulu Xie, Ying Wang, Shan Zhu, Ji‐Ren An, Yuwei Li, Zhikui Tian, Yiqi Yan, Shuang Yu et al. · 2022 · Frontiers in Cellular and Infection Microbiology
GPBA : a GPCR for bile acids and an emerging therapeutic target for disorders of digestion and sensation
T Lieu, G Jayaweera, Nigel W. Bunnett · 2013 · British Journal of Pharmacology
Bile acid metabolism regulatory network orchestrates bone homeostasis
Tingwen Xiang, Zihan Deng, Chuan He Yang, Jiulin Tan, Ce Dou, Fei Luo, Yueqi Chen · 2023 · Pharmacological Research
Fecal Microbiota Transplantation in Combination with Soluble Dietary Fiber for Treatment of Slow Transit Constipation: A Pilot Study
Xiaolong Ge, Hongliang Tian, Chao Ding, Lili Gu, Wei Yao, Jianfeng Gong, Weiming Zhu, Ning Li, Jieshou Li · 2016 · Archives of Medical Research
Intestinal bile acid receptors are key regulators of glucose homeostasis
Mohamed-Sami Trabelsi, Sophie Lestavel, Bart Staels, Xavier Collet · 2016 · Proceedings of The Nutrition Society
Glucose-lowering effects of intestinal bile acid sequestration through enhancement of splanchnic glucose utilization
Janne Prawitt, Sandrine Caron, Bart Staels · 2014 · Trends in Endocrinology and Metabolism
TGR5 in inflammation and cardiovascular disease
Thijs W.H. Pols · 2014 · Biochemical Society Transactions
Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels
Barbora Waclawiková, Amber Bullock, Markus Schwalbe, Carmen Aranzamendi, Sieger A. Nelemans, Gertjan van Dijk, Sahar El Aidy · 2021 · PLoS Biology
Efficacy of Probiotic Compounds in Relieving Constipation and Their Colonization in Gut Microbiota
Yuan He, Leilei Zhu, Jialun Chen, Xin Tang, Mingluo Pan, Weiwei Yuan, Hongchao Wang · 2022 · Molecules
Elobixibat for the treatment of constipation
Victor G Chedid, Priya Vijayvargiya, Michael Camilleri · 2018 · Expert Review of Gastroenterology & Hepatology
Communication between the gut microbiota and peripheral nervous system in health and chronic disease
Tyler M. Cook, Virginie Mansuy‐Aubert · 2022 · Gut Microbes
Microbial sensing in the intestine
Tingting Wan, Yalong Wang, Kaixin He, Shu Zhu · 2023 · Protein & Cell
The gut–brain axis and pain signalling mechanisms in the gastrointestinal tract
Kimberly A. Meerschaert, Isaac M. Chiu · 2024 · Nature Reviews Gastroenterology & Hepatology
Physiology of Electrolyte Transport in the Gut: Implications for Disease
Mrinalini Chatta Rao · 2019 · Comprehensive physiology
Potential Roles of Enterochromaffin Cells in Early Life Stress-Induced Irritable Bowel Syndrome
Enfu Tao, Zhenya Zhu, Chenmin Hu, Gao Long, Bo Chen, Rui Chen Guo, Marong Fang, Mizu Jiang · 2022 · Frontiers in Cellular Neuroscience
TGR5 in cholangiocytes
Verena Keitel, Dieter Häussinger · 2013 · Current Opinion in Gastroenterology
Fecal Microbiota Transplantation Can Alleviate Gastrointestinal Transit in Rats with High-Fat Diet-Induced Obesity via Regulation of Serotonin Biosynthesis
Wenjing Sun, Yan Guo, Shirong Zhang, Zhihui Chen, Kangqi Wu, Qin Liu, Kaijun Liu, Liangzhi Wen, Yanling Wei, Bin Wang et al. · 2018 · BioMed Research International
Redox‐Dependent Effects in the Physiopathological Role of Bile Acids
Josué Orozco-Aguilar, Felipe Simón, Claudio Cabello‐Verrugio · 2021 · Oxidative Medicine and Cellular Longevity
Nanocrystalline Cellulose Cures Constipation via Gut Microbiota Metabolism
Mingzheng Wang, Ruitao Cha, Wenshuai Hao, Ran Du, Pai Zhang, Yingmo Hu, Xingyu Jiang · 2022 · ACS Nano
Crosstalk Between Bile Acids and Intestinal Epithelium: Multidimensional Roles of Farnesoid X Receptor and Takeda G Protein Receptor 5
Xiulian Lin, Li Xia, Yuanjiao Zhou, Jingchen Xie, Qinhui Tuo, Limei Lin, Duan‐Fang Liao · 2025 · International Journal of Molecular Sciences
Update on Bile Acid Malabsorption: Finally Ready for Prime Time?
Priya Vijayvargiya, Michael Camilleri · 2018 · Current Gastroenterology Reports
Intestinal Secretory Mechanisms in Irritable Bowel Syndrome–Diarrhea
Michael Camilleri · 2014 · Clinical Gastroenterology and Hepatology
Comparison of biochemical, microbial and mucosal mRNA expression in bile acid diarrhoea and irritable bowel syndrome with diarrhoea
Michael Camilleri, Paula Carlson, Joelle BouSaba, Sanna McKinzie, Priya Vijayvargiya, Yorick Magnus, Wassel Sannaa, Xiao‐Jing Wang, Victor G Chedid, Ting Zheng et al. · 2022 · Gut
The Role of FGF19 and MALRD1 in Enterohepatic Bile Acid Signaling
Linda X. Wang, Mark R. Frey, Rohit Kohli · 2022 · Frontiers in Endocrinology
Linking serotonin homeostasis to gut function: Nutrition, gut microbiota and beyond
Lili Jiang, Dandan Han, Youling Hao, Zhuan Song, Zhiyuan Sun, Zhaolai Dai · 2023 · Critical Reviews in Food Science and Nutrition
Fine-tuning the gut ecosystem: the current landscape and outlook of artificial microbiome therapeutics
Serena Porcari, William G. Fusco, Igor Spivak, Marcello Fiorani, Antonio Gasbarrini, Eran Elinav, Giovanni Cammarota, Gianluca Ianiro · 2024 · The Lancet. Gastroenterology & hepatology
Molecular mechanism and therapeutic strategy of bile acids in Alzheimer’s disease from the emerging perspective of the microbiota–gut–brain axis
Menglu Wu, Yongyi Cheng, Ruolin Zhang, Wenwen Han, Hanqi Jiang, Chenchen Bi, Ziyi Zhang, Mengfei Ye, Xiuqin Lin, Zheng Liu · 2024 · Biomedicine & Pharmacotherapy
Steroidal Scaffolds as FXR and GPBAR1 Ligands: From Chemistry to Therapeutical Application
Valentina Sepe, Eleonora Distrutti, Vittorio Limongelli, Stefano Fiorucci, Angela Zampella · 2015 · Future Medicinal Chemistry
Interplay between gut microbiota, its metabolites and human metabolism: Dissecting cause from consequence
Annick V. Hartstra, Max Nieuwdorp, Hilde Herrema · 2016 · Trends in Food Science & Technology
Chemical and molecular factors in irritable bowel syndrome: current knowledge, challenges, and unanswered questions
Michael Camilleri, Ibironke Oduyebo, Houssam Halawi · 2016 · American Journal of Physiology-Gastrointestinal and Liver Physiology
Healthy Intestinal Function Relies on Coordinated Enteric Nervous System, Immune System, and Epithelium Responses
Fatima B. Saldana-Morales, Dasom V. Kim, Ming-Ting Tsai, Gretchen E. Diehl · 2021 · Gut Microbes
Open: Effects of NGM282, an FGF19 variant, on colonic transit and bowel function in functional constipation: a randomized phase 2 trial
Ibironke Oduyebo, Michael Camilleri, Alfred D. Nelson, Disha Khemani, Sara Linker Nord, Irene A. Busciglio, Duane D. Burton, Deborah L. Rhoten, Michael D. Ryks, Paula Carlson et al. · 2018 · The American Journal of Gastroenterology
Bile Formation and the Enterohepatic Circulation
Paul A. Dawson · 2018 · Elsevier eBooks
Effect of the gut microbiota and their metabolites on postoperative intestinal motility and its underlying mechanisms
Tianrong Ma, Xiaolei Xue, Hui Tian, XinXiu Zhou, Jun-Ke Wang, Zhiwen Zhao, Mingfei Wang, JiYuan Song, Renxiang Feng, Leping Li et al. · 2023 · Journal of Translational Medicine
The Bile Acid Receptor TGR5 and Liver Regeneration
V. Bidault, Noémie Pean, Isabelle Doignon, Lydie Humbert, Dominique P. Rainteau, Thierry Tordjmann · 2015 · Digestive Diseases
G-protein–coupled receptors are dynamic regulators of digestion and targets for digestive diseases
Canals, Meritxell, Poole, Daniel P., Veldhuis, Nicholas A., Schmidt, Brian L., Bunnett, Nigel W. · 2019 · Gastroenterology
Contributions of bile acids to gastrointestinal physiology as receptor agonists and modifiers of ion channels
Stephen J. Keely, Andreacarola Urso, Alexandr V. Ilyaskin, Christoph Korbmacher, Nigel W. Bunnett, Daniel P. Poole, Simona Carbone · 2021 · American Journal of Physiology-Gastrointestinal and Liver Physiology
Bile and circulating HMGB1 contributes to systemic inflammation in obstructive jaundice
Runkuan Yang, Shengtao Zhu, Soeren Erik Pischke, Håkon Haugaa, Xiaoping Zou, Tor Inge Tønnessen · 2018 · Journal of Surgical Research
Enteroendocrine Cells: Metabolic Relays between Microbes and Their Host
Plovier, Hubert, Cani, Patrice D. · 2017 · Endocrine Development
The associations of gut microbiota, endocrine system and bone metabolism
Ye Tu, Xinyi Kuang, Ling Zhang, Xin Xu · 2023 · Frontiers in Microbiology
Gut Microbiota Metabolites: Unveiling Their Role in Inflammatory Bowel Diseases and Fibrosis
Francesca Bernardi, Ferdinando D’Amico, Sarah Bencardino, Ilaria Faggiani, Jacopo Fanizza, Alessandra Zilli, Tommaso Lorenzo Parigi, Mariangela Allocca, Silvio Danese, Federica Furfaro · 2024 · Pharmaceuticals
Deoxycholic acid activates colonic afferent nerves via 5-HT3 receptor-dependent and -independent mechanisms
Yang Yu, Egina C. Villalobos-Hernández, Sabindra Pradhananga, Corey C. Baker, Christopher D. Keating, David Grundy, Alan E. Lomax, David E. Reed · 2019 · American Journal of Physiology-Gastrointestinal and Liver Physiology
Bacterial-Induced Blood Pressure Reduction: Mechanisms for the Treatment of Hypertension via the Gut
Tyler Alexander Cookson · 2021 · Frontiers in Cardiovascular Medicine
Epigenetic Regulation of Enteric Neurotransmission by Gut Bacteria
Tor Savidge · 2016 · Frontiers in Cellular Neuroscience
The function of the gut microbiota–bile acid–TGR5 axis in diarrhea-predominant irritable bowel syndrome
Kai Zhan, Haomeng Wu, Yongyin Xu, Kehan Rao, Huan Zheng, Shumin Qin, Yuanming Yang, Rui Jia, Weihuan Chen, Shaogang Huang · 2024 · mSystems
Bile acid activated receptors are targets for regulation of integrity of gastrointestinal mucosa
Eleonora Distrutti, Luca Santucci, Sabrina Cipriani, Barbara Renga, Elisabetta Schiaroli, Patrizia Ricci, Annibale Donini, Stefano Fiorucci · 2015 · Journal of Gastroenterology
Abnormal Gastrointestinal Motility Is a Major Factor in Explaining Symptoms and a Potential Therapeutic Target in Patients with Disorders of Gut Brain Interaction
Michael Camilleri · 2023 · Gut
Age-Related Changes in Gut Microbiota Alter Phenotype of Muscularis Macrophages and Disrupt Gastrointestinal Motility
Laren S. Becker, Estelle Spear Bishop, Sidhartha R. Sinha, Yeneneh Haileselassie, Aida Habtezion · 2018 · Cellular and Molecular Gastroenterology and Hepatology
Targeting G protein-coupled receptors for the treatment of chronic pain in the digestive system
Lena Gottesman-Katz, Rocco Latorre, Stephen J. Vanner, Brian L. Schmidt, Nigel W. Bunnett · 2020 · Gut
Bile acids, bioactive signalling molecules in interoceptive gut‐to‐brain communication
Susan A. Joyce, Dervla O'Malley · 2022 · The Journal of Physiology
HuangQin Decoction Attenuates CPT-11-Induced Gastrointestinal Toxicity by Regulating Bile Acids Metabolism Homeostasis
Xu Wang, Dong-Ni Cui, Xiaomin Dai, Jing Wang, Wei Zhang, Zunjian Zhang, Fengguo Xu · 2017 · Frontiers in Pharmacology
Research Advances in Protective Effects of Ursolic Acid and Oleanolic Acid Against Gastrointestinal Diseases
Yajing Shi, Yufang Leng, Disheng Liu, Xin Liu, Yixing Ren, Jianmin Zhang, Feng Chen · 2021 · The American Journal of Chinese Medicine
A Special Network Comprised of Macrophages, Epithelial Cells, and Gut Microbiota for Gut Homeostasis
Wei Chen, Dan Liu, Changhao Ren, Lei Su, Chun Kwok Wong, Rongcun Yang · 2022 · Cells
The Intestinal Fatty Acid-Enteroendocrine Interplay, Emerging Roles for Olfactory Signaling and Serotonin Conjugates
Jocelijn Meijerink · 2021 · Molecules
Anti-diabetic effect of dicaffeoylquinic acids is associated with the modulation of gut microbiota and bile acid metabolism
Yujie Huang, Weiqi Xu, Wei Dong, Guijie Chen, Yi Sun, Xiaoxiong Zeng · 2024 · Journal of Advanced Research
Gut feelings: the microbiota-gut-brain axis on steroids
Sik Yu So, Tor Savidge · 2021 · American Journal of Physiology-Gastrointestinal and Liver Physiology
Circadian rhythms in colonic function
Timothy James Hibberd, Stewart D. Ramsay, Phaedra Spencer-Merris, Phil G. Dinning, Vladimir P. Zagorodnyuk, Nick J. Spencer · 2023 · Frontiers in Physiology
The role of botanical triterpenoids and steroids in bile acid metabolism, transport, and signaling: Pharmacological and toxicological implications
Zichen Luo, Wei Zhou, Tong Xie, Weichen Xu, Chen Shi, Zihan Xiao, Yu Si, Yan Ma, Qingling Ren, Liuqing Di et al. · 2024 · Acta Pharmaceutica Sinica B
The benefit of elobixibat in chronic constipation is associated with faecal deoxycholic acid but not effects of altered microbiota
Noboru Misawa, Takuma Higurashi, Tomohiro Takatsu, Michihiro Iwaki, Takashi Kobayashi, Tsutomu Yoshihara, Keiichi Ashikari, Takaomi Kessoku, Akiko Fuyuki, Tetsuya Matsuura et al. · 2020 · Alimentary Pharmacology & Therapeutics
Lactic acid bacteria in relieving constipation: mechanism, clinical application, challenge, and opportunity
Tong Zhang, Wenxu Liu, Huimin Lu, Ting Cheng, Linlin Wang, Gang Wang, Hao Zhang, Wei Chen · 2023 · Critical Reviews in Food Science and Nutrition
Neonatal development of intestinal neuroimmune interactions
Ellen Merrick Schill, Alexandria N. Floyd, Rodney D. Newberry · 2022 · Trends in Neurosciences
Dietary SCFAs, IL-22, and GFAP: The Three Musketeers in the Gut–Neuro–Immune Network in Type 1 Diabetes
Abhirup Jayasimhan, Eliana Mariño · 2019 · Frontiers in Immunology
Bile Acids and Microbiome Among Individuals With Irritable Bowel Syndrome and Healthy Volunteers
Kendra Kamp, Kevin C. Cain, Angelita G. Utleg, Robert L. Burr, Daniel Raftery, Ruth Ann Luna, Robert Jay Shulman, Margaret McLean Heitkemper · 2020 · Biological Research For Nursing
Overview of the microbiota in the gut-liver axis in viral B and C hepatitis
Maria Adriana Neag, Andrei Otto Mitre, Adrian Cătinean, Anca Dana Buzoianu · 2021 · World Journal of Gastroenterology
Alteration in bile acids profile in large white pigs during chronic heat exposure
Fang, Wei, Wen, Xiaobin, Meng, Qingshi, Wu, Weida, Everaert, Nadia, Xie, Jingjing, Zhang, Hongfu · 2019 · Journal of Thermal Biology
Bacillus Subtilis Promotes the Release of 5-HT to Regulate Intestinal Peristalsis in STC Mice via Bile Acid and Its Receptor TGR5 Pathway
Zhenhai Chen, Jiangyi Feng, Song Hu, Hua Ye, Shaying Ma, Weijie Fu, Qian Yang, Xin Zhang · 2021 · Digestive Diseases and Sciences
Bile acids and FXR in functional gastrointestinal disorders
Paula Mosińska, Adrian Szczepaniak, Jakub Fichna · 2018 · Digestive and Liver Disease
Torreya grandis Kernel Oil Alleviates Loperamide‐Induced Slow Transit Constipation via Up‐Regulating the Colonic Expressions of Occludin/Claudin‐1/ZO‐1 and 5‐HT3R/5‐HT4R in BALB/c Mice
Xuezhu Wang, Rui Guo, Zhuoli Yu, Lalai Zikela, Jiaomei Li, Songtao Li, Qiang Han · 2023 · Molecular Nutrition & Food Research
Probiotics Improve Gastrointestinal Function and Life Quality in Pregnancy
Albert Tianxiang Liu, Shuai Chen, Prasant Kumar Jena, Lili Sheng, Ying Chuan Hu, Yu‐Jui Yvonne Wan · 2021 · Nutrients
Resistant Starch and Microbiota-Derived Secondary Metabolites: A Focus on Postbiotic Pathways in Gut Health and Irritable Bowel Syndrome
Enikő Kovács, Katalin Szabo, Rodica-Anita Varvara, Alina Uifălean, Angela Cozma, Romana Vulturar, Adela Sitar-Tăut, Rosita Gabbianelli, Mari C. W. Myhrstad, Vibeke H. Telle‐Hansen et al. · 2025 · International Journal of Molecular Sciences
Bile acid composition regulates the manganese transporter Slc30a10 in intestine
Tiara R. Ahmad, Sei Higuchi, Enrico Bertaggia, Allison Hung, Niroshan Shanmugarajah, Nicole C. Guilz, Jennifer R. Gamarra, Rebecca A. Haeusler · 2020 · Journal of Biological Chemistry
Review article: Elobixibat: a novel treatment for chronic constipation
Lehar Khanna, Michael Camilleri · 2020 · Alimentary Pharmacology & Therapeutics
Paeoniflorin Improved Constipation in the Loperamide-Induced Rat Model via TGR5/TRPA1 Signaling-Mediated 5-Hydroxytryptamine Secretion
Yu Zhan, Yong Wen, Liangliang Zhang, Xu-long Shen, Xiao-hui Chen, Xiao-hai Wu, Xuegui Tang · 2021 · Evidence-based Complementary and Alternative Medicine
Bile acid–gut microbiota crosstalk in irritable bowel syndrome
Yu Gu, Lingfeng Li, Min Yang, Tianyu Liu, Xueli Song, Xiali Qin, Xin Juan Xu, Jinghua Liu, Bangmao Wang, Hailong Cao · 2022 · Critical Reviews in Microbiology
A Shigella species variant is causally linked to intractable functional constipation
Xin Chen, Tian-Tian Qiu, Ye Wang, Li-Yang Xu, Jie Sun, Zhihui Jiang, Wei Han Zhao, Tao Tao, Yuwei Zhou, Lisha Wei et al. · 2022 · Journal of Clinical Investigation
Gut–Liver Axis in Nonalcoholic Fatty Liver Disease: the Impact of the Metagenome, End Products, and the Epithelial and Vascular Barriers
Antonio Gil‐Gómez, Paola Brescia, María Rescigno, Manuel Romero‐Gómez · 2021 · Seminars in Liver Disease
Aberrant Gut-To-Brain Signaling in Irritable Bowel Syndrome - The Role of Bile Acids
Róisín Ní Dhonnabháín, Qiao Xiao, Dervla O’Malley · 2021 · Frontiers in Endocrinology
Metabolomics analysis of Pulsatilla decoction on treatment of wetness‐heat‐induced diarrhea in rats based on UPLC–Q/TOF–MS/MS
Yongli Hua, Qi Ma, Wei Li, Xiao‐song Zhang, Xiao‐hua Cheng, Ya‐qian Jia, Xiao‐ting Peng, Wanling Yao, Peng Ji, Junjie Hu et al. · 2019 · Biomedical Chromatography
Synthetic G protein‐coupled bile acid receptor agonists and bile acids act via basolateral receptors in ileal and colonic mucosa
Iain R. Tough, Thue Walter Schwartz, Helen M. Cox · 2020 · Neurogastroenterology & Motility
Total alditols from Cistanche deserticola attenuate functional constipation by regulating bile acid metabolism
Hongmei Yin, Xia Gao, Hao Yang, Zhong-Kun Xu, Xuening Wang, Xuesong Wang, Yunjia Gao, Ziyi Shi, Xialin Chen, Liang Cao et al. · 2023 · Journal of Ethnopharmacology