Bile acids: Key players in inflammatory bowel diseases?
Open accessAbstract
Inflammatory bowel diseases (IBDs) have emerged as a public health problem worldwide with a limited number of efficient therapeutic options despite advances in medical therapy. Although changes in the gut microbiota composition are recognized as key drivers of dysregulated intestinal immunity, alterations in bile acids (BAs) have been shown to influence gut homeostasis and contribute to the pathogenesis of the disease. In this review, we explore the interactions involving BAs and gut microbiota in IBDs, and discuss how the gut microbiota-BA-host axis may influence digestive inflammation.
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Bile acids are microbiota-associated metabolites that regulate intestinal homeostasis and inflammation in ulcerative colitis.
“Bile acids (BAs) are microbiota-associated metabolites that regulate intestinal homeostasis and inflammation in UC (Kriaa et al., 2022).”
From Bacteroides dorei BDX-01 alleviates DSS-induced experimental colitis in mice by regulating intestinal bile salt hydrolase activity and the FXR-NLRP3 signaling pathway (2023) · cites this paper as Kriaa et al., 2022
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Sun, X., Chen, Z., Yu, L., Zeng, W., Sun, B., Fan, H., & Bai, Y. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1205323 · Cited by 33 · see citing works
“Bile acids (BAs) are microbiota-associated metabolites that regulate intestinal homeostasis and inflammation in UC (Kriaa et al., 2022).”
Background
- Authors
- Kriaa, A., Mariaule, V., Jablaoui, A., Rhimi, S., Mkaouar, H., Hernandez, J., Korkmaz, B., Lesner, A., Maguin, E., Aghdassi, A., & Rhimi, M.
- Affiliations
- Microbiota Interaction with Human and Animal Team (MIHA), Micalis Institute, AgroParisTech, Université Paris-Saclay, INRAE, 78350 Jouy-en-Josas, France
- AgroParisTech (FR)
- Oniris (FR)
- Université de Tours (FR)
- University of Gdańsk (PL)
- Universitätsmedizin Greifswald (DE)
- Corresponding author
- Rhimi, Moez
- ORCID
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2022-03-05
- Volume
- 11
- Issue
- 5
- Pages
- 901
- ISSN
- 2073-4409 (ISSN-L)
- PMC
- PMC8909766
- OpenAlex
- W4221118842
- Cited by
- 53
- References
- 74
- Citations by year
- 2026: 11 · 2025: 9 · 2024: 15 · 2023: 12 · 2022: 6
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cells (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- HAL (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Research Institute for Agriculture, Food and Environment (MICA department)
- Oniris (Animal microbiota analysis project)
- European Commission (MICAfrica)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- bile acids, inflammatory bowel disease, gut microbiota, intestinal inflammation, intestinal homeostasis, IBD pathogenesis
- MeSH terms
- Gastrointestinal Microbiome, Bile Acids and Salts, Homeostasis, Humans, Inflammation, Inflammatory Bowel Diseases
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