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Therapeutic Potential of Fecal Microbiota Transplantation
Open accessAbstract
There has been growing interest in the use of fecal microbiota for the treatment of patients with chronic gastrointestinal infections and inflammatory bowel diseases. Lately, there has also been interest in its therapeutic potential for cardiometabolic, autoimmune, and other extraintestinal conditions that were not previously considered to be associated with the intestinal microbiota. Although it is not clear if changes in the microbiota cause these conditions, we review the most current and best methods for performing fecal microbiota transplantation and summarize clinical observations that have implicated the intestinal microbiota in various diseases. We also discuss case reports of fecal microbiota transplantations for different disorders, including Clostridium difficile infection, irritable bowel syndrome, inflammatory bowel diseases, insulin resistance, multiple sclerosis, and idiopathic thrombocytopenic purpura. There has been increasing focus on the interaction between the intestinal microbiome, obesity, and cardiometabolic diseases, and we explore these relationships and the potential roles of different microbial strains. We might someday be able to mine for intestinal bacterial strains that can be used in the diagnosis or treatment of these diseases.
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Metadata
- Authors
- Smits, L. P., Bouter, K. E. C., de Vos, W. M., Borody, T. J., & Nieuwdorp, M.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Centre For Digestive Diseases (AU)
- Corresponding author
- Nieuwdorp, Max
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 145
- Issue
- 5
- Pages
- 946-953
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2135717147
- Cited by
- 717
- References
- 81
- Citations by year
- 2026: 28 · 2025: 47 · 2024: 66 · 2023: 57 · 2022: 74 · 2021: 63 · 2020: 67 · 2019: 52 · 2018: 42 · 2017: 45 · 2016: 54 · 2015: 54 · 2014: 59 · 2013: 7
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- green
- research.wur.nl
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- fecal microbiota transplantation, gut microbiota, Clostridium difficile infection, irritable bowel syndrome, inflammatory bowel disease, insulin resistance, multiple sclerosis, idiopathic thrombocytopenic purpura, cardiometabolic disease, obesity, autoimmune disease, extraintestinal diseases
- MeSH terms
- Enterocolitis, Pseudomembranous, Feces, Gastrointestinal Diseases, Humans, Transplantation, Homologous, Inflammatory Bowel Diseases, Clostridioides difficile, Treatment Outcome, Transplants, Microbiota
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