Global and Deep Molecular Analysis of Microbiota Signatures in Fecal Samples From Patients With Irritable Bowel Syndrome
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Background & aims Irritable bowel syndrome (IBS) has been associated with disruptions to the intestinal microbiota, but studies have had limited power, coverage, and depth of analysis. We aimed to define microbial populations that can be used discriminate the fecal microbiota of patients with IBS from that of healthy subjects and correlate these with IBS intestinal symptom scores.Methods The microbiota composition was assessed by global and deep molecular analysis of fecal samples from 62 patients with IBS patients and 46 healthy individuals (controls). We used a comprehensive and highly reproducible phylogenetic microarray in combination with quantitative polymerase chain reaction.Results The intestinal microbiota of IBS patients differed significantly (P = .0005) from that of controls. The microbiota of patients, compared with controls, had a 2-fold increased ratio of the Firmicutes to Bacteroidetes (P = .0002). This resulted from an approximately 1.5-fold increase in numbers of Dorea, Ruminococcus, and Clostridium spp (P < .005); a 2-fold decrease in the number of Bacteroidetes (P < .0001); a 1.5-fold decrease in numbers of Bifidobacterium and Faecalibacterium spp (P < .05); and, when present, a 4-fold lower average number of methanogens (3.50 × 10(7) vs 8.74 × 10(6) cells/g feces; P = .003). Correlation analysis of the microbial groups and IBS symptom scores indicated the involvement of several groups of Firmicutes and Proteobacteria in the pathogenesis of IBS.Conclusions Global and deep molecular analysis of fecal samples indicates that patients with IBS have a different composition of microbiota. This information might be used to develop better diagnostics and ultimately treatments for IBS.
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A recent study demonstrated that faecal microbiota of irritable bowel syndrome patients could be grouped in a cluster which was completely different from that of healthy controls.
“Interestingly, a recent study demonstrated that faecal microbiota of IBS patients could be grouped in a cluster which was completely different from that of healthy controls.114”
From Intestinal microbiota in functional bowel disorders: a Rome foundation report (2013) · cites this paper as [114]
Recent studies using advanced molecular biology techniques have demonstrated quantitative alterations of specific bacterial groups in patients with IBS compared with healthy controls.
“Recent studies using these advanced molecular biology techniques have demonstrated quantitative alterations of specific bacterial groups (33, 34, 81, 85, 142, 154) and reduced diversity in gut microbial populations in patients with IBS compared with healthy controls (33, 40).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [142]
Limited data suggest differences in intestinal microbiota between IBS subtypes.
“Limited data also suggest differences in mucosa-associated microbiota (32, 33, 86, 129), reduced stability over time (106, 107), rDNA, and differences between IBS subtypes (81, 104, 129, 142).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [142]
The genus Blautia displays a high incidence in patients with IBD.
“Moreover, the genus Blautia, recently reorganized to refer to several misclassified species belonging to the Clostridium cluster XIVa, which according to our study is more abundant in women than in men under obesity condition, display a high incidence in patients with IBD [53, 54].”
From Intestinal Microbiota Is Influenced by Gender and Body Mass Index (2016) · cites this paper as [54]
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- Authors
- Rajilić–Stojanović, M., Biagi, E., Heilig, H. G. H. J., Kajander, K., Kekkonen, R. A., Tims, S., & de Vos, W. M.
- Affiliations
- Wageningen University & Research (NL)
- Valio (Finland) (FI)
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 141
- Issue
- 5
- Pages
- 1792-1801
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2123812491
- Cited by
- 1,041
- References
- 49
- Citations by year
- 2026: 27 · 2025: 51 · 2024: 91 · 2023: 69 · 2022: 74 · 2021: 84 · 2020: 96 · 2019: 68 · 2018: 90 · 2017: 86 · 2016: 73 · 2015: 59 · 2014: 69 · 2013: 66 · 2012: 33
- FWCI
- 22.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- TechnoRep (University of Belgrade – Faculty of Technology and Metallurgy) (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Epidemiology › Microscopic Colitis
- Keywords
- irritable bowel syndrome, gut microbiota, fecal microbiota composition, Firmicutes/Bacteroidetes ratio, Dorea, Ruminococcus, Clostridium, Bifidobacterium, Faecalibacterium, methanogenic archaea, Proteobacteria
- MeSH terms
- Adult, Aged, Bifidobacterium, Clostridium, Feces, Female, Humans, Male, Middle Aged, Phylogeny, Case-Control Studies, Irritable Bowel Syndrome, Ruminococcus, Microarray Analysis, Metagenome
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