Hypoxia-Inducible Factors Link Iron Homeostasis and Erythropoiesis

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation

Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180

Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization

Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing

Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

Forsythe, J. A., Jiang, B.-H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D., & Semenza, G. L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4604 · Cited by 3,981

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

Gunshin, H., Mackenzie, B., Berger, U. V., Gunshin, Y., Romero, M. F., Boron, W. F., Nussberger, S., Gollan, J. L., & Hediger, M. A. (1997) · Nature · doi:10.1038/41343 · Cited by 3,166

IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420945 · Cited by 2,650

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

Semenza, G. L., & Wang, G. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5447 · Cited by 2,617

Activation of Intestinal HIF2α Ameliorates Iron‐Refractory Anemia

Yu, Y., Su, Y., Yang, S., Liu, Y., Lin, Z., Das, N. K., Wu, Q., Zhou, J., Sun, S., Li, X., et al. (2024) · Advanced Science · doi:10.1002/advs.202307022 · Cited by 14

Genetic screens reveal CCDC115 as a modulator of erythroid iron and heme trafficking

Sobh, A., Loguinov, A. V., Zhou, J., Jenkitkasemwong, S., Zeidan, R. S., Ahmadie, N. E., Tagmount, A., Knutson, M. D., Fraenkel, P. G., & Vulpe, C. D. (2020) · American Journal of Hematology · doi:10.1002/ajh.25899 · Cited by 13

HIF-1α and NFIA-AS2 Polymorphisms as Potential Determinants of Total Hemoglobin Mass in Endurance Athletes

Malczewska‐Lenczowska, J., Orysiak, J., Majorczyk, E., Sitkowski, D., Starczewski, M., & Żmijewski, P. (2020) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000003686 · Cited by 13

Prolyl-hydroxylase inhibitors for the treatment of anemia in chronic kidney disease

McMahon, G. M., & Singh, A. K. (2019) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000554 · Cited by 12

Iron homeostasis and post-hemorrhagic hydrocephalus: a review

Pan, S., Hale, A. T., Lemieux, M., Raval, D. K., Garton, T. P., Sadler, B. E., Mahaney, K. B., & Strahle, J. M. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2023.1287559 · Cited by 11

Influence of mitochondrial and systemic iron levels in heart failure pathology

Lupu, M., Tudor, D. V., & Filip, G. A. (2019) · Heart Failure Reviews · doi:10.1007/s10741-019-09788-z · Cited by 13

Relationship between Down-Regulation of Copper-Related Genes and Decreased Ferroportin Protein Level in the Duodenum of Iron-Deficient Piglets

Jończy, A., Mazgaj, R., Starzyński, R. R., Poznański, P., Szudzik, M., Smuda, E., Kamyczek, M., & Lipiński, P. (2020) · Nutrients · doi:10.3390/nu13010104 · Cited by 9

Preferred Conformation-Guided Discovery of Potent and Orally Active HIF Prolyl Hydroxylase 2 Inhibitors for the Treatment of Anemia

Wu, Y., Zhang, L., Sun, Z., Qiu, X., Chen, Y., Su, K., Yang, L., Du, Z., Dong, Y., Yang, F., et al. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c00231 · Cited by 9

Hookworm infection as a model for deepen knowledge of iron metabolism and erythropoiesis in anemia

Furtado, L. F. V., Alves, W. P., da Silva, V. J., & Rabelo, É. M. L. (2024) · Cytokine · doi:10.1016/j.cyto.2024.156559 · Cited by 10

Non-Anticoagulation Strategies Aimed at Primary Stroke Prevention in Nascent Atrial Fibrillation

Sgarra, L., Desantis, V., Matteucci, A., Caccavo, V. P., Troisi, F., Monaco, A. D., Mangini, F., Katsouras, G., Guaricci, A. I., Dadamo, M. L., et al. (2025) · Biomedicines · doi:10.3390/biomedicines13030660 · Cited by 9

The relationships among gut microbiota, hypoxia‐inducible factor and anaemia with chronic kidney disease

Liu, L., Xu, W., Kong, P., & Dou, Y. (2022) · Nephrology · doi:10.1111/nep.14064 · Cited by 8

Cellular Pre-Adaptation to the High O2 Concentration Used in Standard Cell Culture Confers Resistance to Subsequent H2O2-Induced Cell Death

Jordan, J. B., Smallwood, M. J., Smerdon, G. R., & Winyard, P. G. (2024) · Antioxidants · doi:10.3390/antiox13030269 · Cited by 8

Microglial EPOR Contribute to Sevoflurane-induced Developmental Fine Motor Deficits Through Synaptic Pruning in Mice

He, D., Shi, X., Liang, L., Zhao, Y., Ma, S., Cao, S., Liu, B., Gao, Z.-Z., Zhang, X., Fan, Z., et al. (2024) · Neuroscience Bulletin · doi:10.1007/s12264-024-01248-5 · Cited by 9

Novel Iron Parameters in Patients with Type 2 Diabetes Mellitus in Relation to Kidney Function

Zapora-Kurel, A., Kuźma, Ł., Zakrzewska, M., Żórawski, M., Dobrzycki, S., Twardowska-Kawalec, M., & Małyszko, J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10163732 · Cited by 8

Is the Role of Hepcidin and Erythroferrone in the Pathogenesis of Beta Thalassemia the Key to Developing Novel Treatment Strategies?

Au, T. Y., Benjamin, S., & Wiśniewski, O. W. (2022) · Thalassemia Reports · doi:10.3390/thalassrep12030017 · Cited by 8

A comprehensive assessment of networks and pathways of hypoxia-associated proteins and identification of responsive protein modules

Khurana, P., Tiwari, D., Sugadev, R., Sarkar, S., & Singh, S. B. (2016) · Network Modeling Analysis in Health Informatics and Bioinformatics · doi:10.1007/s13721-016-0123-8 · Cited by 8

Identification of small-molecule ligand-binding sites on and in the ARNT PAS-B domain

Xu, X., Closson, J. D., Marcelino, L. P., Favaro, D. C., Silvestrini, M., Solazzo, R., Chong, L. T., & Gardner, K. H. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107606 · Cited by 7

The Effects of Mild Intermittent Hypoxia Exposure on the Abdominal Subcutaneous Adipose Tissue Proteome in Overweight and Obese Men: A First-in-Human Randomized, Single-Blind, and Cross-Over Study

van Meijel, R. L. J., Wang, P., Bouwman, F. G., Blaak, E. E., Mariman, E. C. M., & Goossens, G. H. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.791588 · Cited by 7

Effect of hypobaric hypoxia on hematological parameters related to oxygen transport, blood volume and oxygen consumption in adolescent endurance-training athletes

Mancera-Soto, É. M., Acosta, M. L. C., Ramos‐Caballero, D. M., Torrella, J. R., & Cristancho-Mejía, É. (2022) · Journal of Exercise Science & Fitness · doi:10.1016/j.jesf.2022.10.003 · Cited by 7

The expression of embryonic globin mRNA in a severely anemic mouse model induced by treatment with nitrogen-containing bisphosphonate

Otsuka, H., Takito, J., Endo, Y., Yagi, H., Soeta, S., Yanagisawa, N., Nonaka, N., & Nakamura, M. (2016) · BMC Hematology · doi:10.1186/s12878-016-0041-0 · Cited by 7

AMP‐activated protein kinase α1 phosphorylates PHD2 to maintain systemic iron homeostasis

Wang, C., Zhang, W., Xu, W., Liu, Z., & Huang, K. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.854 · Cited by 9

Free iron accumulation and oxidative stress burden induce ferroptotic atrophy of chicken yolk sac during the late embryogenesis

Liu, H., Song, Z., He, X., & Zhang, H. (2024) · Animal Research and One Health · doi:10.1002/aro2.74 · Cited by 5

Transcriptomic Profiling and Pathway Analysis of Mesenchymal Stem Cells Following Low Dose-Rate Radiation Exposure

Slaven, J. E., Wilkerson, M. D., Soltis, A. R., Rittase, W. B., Bradfield, D. T., Bylicky, M. A., Cary, L. H., Tsioplaya, A., Bouten, R. M., Dalgard, C. L., et al. (2023) · Antioxidants · doi:10.3390/antiox12020241 · Cited by 5

Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis Through Malic Enzyme 1 in Pancreatic Cancer CellsPreprint

Ensink, E., Jordan, T., Medeiros, H. C. D., Thurston, G., Pardal, A., Yu, L., & Lunt, S. Y. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.15.557984 · Cited by 5

Serpinb3 is Overexpressed in the Liver in Presence of Iron Overload

Turato, C., KENT, P. G., Sebastiani, G., Cannito, S., Morello, E., Terrin, L., Biasiolo, A., Simonato, D., Parola, M., Pantopoulos, K., et al. (2017) · Journal of Investigative Medicine · doi:10.1136/jim-2017-000473 · Cited by 4

The Influence of Altitude on Erythropoietin Resistance Index in Maintenance Hemodialysis Patients: Data from Tibetan Plateau

Wang, Y., Dang, Z., Gan, L., Ciren, L., Zhang, L., Li, G.-L., & Zuo, L. (2020) · Blood Purification · doi:10.1159/000510997 · Cited by 4

Comprehensive transcriptome analysis of erythroid differentiation potential of olive leaf in haematopoietic stem cells

Kondo, S., Ferdousi, F., Yamauchi, K., Suidasari, S., Yokozawa, M., Harrabi, M. M., Tominaga, K., & Isoda, H. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16752 · Cited by 5

Comparative analysis of high altitude hypoxia induced erythropoiesis and iron homeostasis in Indian and Kyrgyz lowlander males

Gaur, P., Saini, S., Ray, K., Kishore, K., Asanbekovna, K. N., Akunov, A., Maripov, A., Sharma, Y. K., Sharma, S. K., Kumar, B., et al. (2020) · Current Research in Biotechnology · doi:10.1016/j.crbiot.2020.10.001 · Cited by 4

LncRNAs in hypoxic microenvironment; insight in their impact in cancer biology

Kuriakose, B. B., Hjazi, A., Saleh, R. O., Bishoyi, A. K., Jyothi, S. R., Almalki, S. G., Sridevi, G., Chaudhary, K., Zwamel, A. H., & Matchonov, O. (2025) · Functional & Integrative Genomics · doi:10.1007/s10142-025-01635-9 · Cited by 3

Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report

Roth‐Walter, F., Agache, I. O., Cabanillas, B., Canani, R. B., Comberiati, P., Garn, H., Gómez‐Casado, C., Hufnagl, K., Khaleva, E., Milani, G. P., et al. (2026) · Allergy · doi:10.1111/all.70325 · Cited by 3

Iron metabolism: pathways and proteins in homeostasis

Arora, E. K., & Sharma, V. (2022) · Reviews in Inorganic Chemistry · doi:10.1515/revic-2022-0031 · Cited by 3

Prevalence and predictors of restless legs syndrome among patients having stable chronic obstructive pulmonary disease

Maharjan, S., Dua, R., Saini, L. K., Kumar, N., & Gupta, R. M. (2024) · Sleep Medicine · doi:10.1016/j.sleep.2024.03.041 · Cited by 3

The ‘ABC’ of split-nanoluciferase HIF heterodimerization bioassays: Applications, Benefits & Considerations

Janssens, L. K., & Stove, C. P. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116478 · Cited by 3

Dynamics of Iron Homeostasis in Health and Disease: Molecular Mechanisms and Methods for Iron Determination

Ploumi, C., Kyriakakis, E., & Tavernarakis, N. (2019) · Series in bioengineering · doi:10.1007/978-981-13-0989-2_5 · Cited by 3

Myeloid Hif2α is not essential to maintain systemic iron homeostasis

Jain, C., Parimi, S., Huang, W., Hannifin, S., Singhal, R., Das, N. K., Lee, K. E., & Shah, Y. M. (2023) · Experimental Hematology · doi:10.1016/j.exphem.2023.08.001 · Cited by 2

Red Meat Consumption, Iron Status, and Cardiometabolic Risk in Qatari Adults: A Cross-Sectional Gender-Stratified Analysis from the QPHI-QBB Data in Qatar

Mousa, H., Razeq, N. M. A., Khial, Y., & Tayyem, R. (2025) · Foods · doi:10.3390/foods14122134 · Cited by 2

Hypoxia-Inducible Factor 1-alpha (HIF1α), Nicotinamide Adenine Dinucleotide (NAD+, NADH), and Nitric Oxide (NO) interplay in critically ill patients, with implications for patient safety and targeted therapies: a review

Bar‐Or, D., Banton, K. L., Acuna, D. L., Williams, J. G., Palacio, C. H., Mains, C. W., & Garrett, R. E. (2025) · Patient Safety in Surgery · doi:10.1186/s13037-025-00453-z · Cited by 2

NAG-1/GDF15 modulates hepcidin expression through STAT3 and SMAD pathways

Lertpatipanpong, P., Krisanapun, C., Boonruang, K., Jung, Y. J., & Baek, S. J. (2025) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2025.110724 · Cited by 2

Ferroptosis in Recurrent Vulvovaginal Candidiasis Through Integrated Bioinformatics and Experimental Validation

Hou, Y.-M., Yu, H., Feng, F., Yao, H.-Y., Yao, J.-M., & An, R. (2026) · Antioxidants · doi:10.3390/antiox15040407 · Cited by 2

Pre-existing iron deficiency anemia and long-term risk of recurrent acute kidney injury in survivors of ICU-associated AKI: a propensity-matched study

Hung, K.-C., Weng, H.-L., Ho, C.-N., Wang, L., Lai, Y.-C., Wu, J.-Y., & Chen, I. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1779193 · Cited by 2

Mechanisms of Thrombocytosis in Iron‐Deficiency Anemia

Facco, J. V., Krause, D. S., & Saad, S. T. O. (2026) · European Journal Of Haematology · doi:10.1111/ejh.70211 · Cited by 2

The relativity analysis of hypoxia inducible factor-1α in pulmonary arterial hypertension (ascites syndrome) in broilers: a review

Fang, W., Wang, E., Liu, P., Gao, X., Hou, X., Hu, G., Li, G., Cheng, J., Jiang, C., Yan, L., et al. (2024) · Avian Pathology · doi:10.1080/03079457.2024.2358882 · Cited by 3

Mechanisms and triggers of adaptation to hypoxia

Владимирович, Л. А., Cherkashin, D. V., Валерьевич, Е. С., Alanichev, A. E., Ivanov, V. S., & Кутелев, Г. Г. (2021) · Reviews on Clinical Pharmacology and Drug Therapy · doi:10.17816/rcf193269-280 · Cited by 2

Hypoxia-Inducible Non-coding RNAs in Mesenchymal Stem Cell Fate and Regeneration

Ye, Y., Zhao, X., Xu, Y., & Yu, J. (2021) · Frontiers in Dental Medicine · doi:10.3389/fdmed.2021.799716 · Cited by 5

Can iron chelators ameliorate viral infections?

Pereira, T. A., & Espósito, B. P. (2023) · BioMetals · doi:10.1007/s10534-023-00558-x · Cited by 1

Blood hemoglobin levels of the general population residing at low range altitudes

Mizuta, M., Nishi, H., Odawara, M., Oda, Y., & Nangaku, M. (2024) · Annals of Clinical Epidemiology · doi:10.37737/ace.25002 · Cited by 1

Remodeling of the immune-metabolic landscape triggered by long-term high-altitude exposure

Wang, J., Dong, Y., Xue, R., Huang, Y., Yang, W., Zhang, C., Zhang, Y., Wang, F., Yang, R., Wang, J., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117376 · Cited by 2

Effects of daily low oxygen exposure on weight status, body composition, and metabolic health in adults with obesity: protocol for a randomized, double-blind, controlled-feeding study

Riley, T. M., Weschenfelder, C., Ravussin, É., Rood, J. C., Greenway, F. L., Taff, S., Hickner, R. C., Cao, H., Sutin, A. R., Todd, G., et al. (2025) · Contemporary Clinical Trials · doi:10.1016/j.cct.2025.108167 · Cited by 1

Unveiling melatonin’s multifaceted actions against ferroptotic neurotoxicity in ischemic stroke

Boonmag, S., Reiter, R. J., & Govitrapong, P. (2026) · Toxicology Reports · doi:10.1016/j.toxrep.2026.102219 · Cited by 1

Iron, inflammation, and intestinal tumors: the crucial triad in colorectal cancer progression and therapy

Abediasl, M., Siavash, M., Esfahani, S. S., Amini, Z., Amiri, K., Saket, S., Esmaeili, E., Rafizadeh, F., Saraei, R., & Fakhr, M. S. (2026) · Clinical & Translational Oncology · doi:10.1007/s12094-026-04225-8 · Cited by 1

Therapeutic effects of natural product-based hypoxia-inducible factor inhibitors in age-related retinopathy: A narrative review

Nahar, J. S., Lim, S. S., & Lee, D. (2026) · Aging advances. · doi:10.4103/agingadv.agingadv-d-26-00005 · Cited by 1

Obesity and Iron Metabolism: Mechanisms, Status Assessment, and Clinical Implications

Aguree, S., & Meng, X. (2026) · Current Obesity Reports · doi:10.1007/s13679-026-00753-0 · Cited by 1

Mittlere Höhenlagen – Höhenanpassung und Höhentraining

Schobersberger, W., & Schobersberger, B. (2016) · Springer eBooks · doi:10.1007/978-3-211-99716-1_33 · Cited by 1

Deciphering the involvement of iron targets in colorectal cancer: a network biology approach.

Khan, A. A., Ashraf, M. T., Aldakheel, F. M., Sayi‐Yazgan, A., & Zaidi, R. (2022) · PubMed Central · Cited by 1

New Aspects Regarding the Fluorescence Spectra of Melanin and Neuromelanin in Pigmented Human Tissue Concerning Hypoxia

Leupold, D., Buder, S. C., Pfeifer, L., Szyc, Ł., Riederer, P. F., Strobel, S., & Monoranu, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158457 · Cited by 1

Population genetic structure of Montipora digitata coral-algal symbiosis in the South China Sea

Jia, S., Wang, Y., Li, Y., Wu, Z., Cai, Z., Shen, J., Wang, D., & Chen, S. (2024) · Global Ecology and Conservation · doi:10.1016/j.gecco.2024.e03231 · Cited by 1

Iron-deficiency Anemia and Chronic Kidney Disease: An Overview

Sharma, G., Saxena, R., & Gulati, N. (2018) · doi:10.5005/jp-journals-10065-0037 · Cited by 1

Fe Deficiency, Dietary Bioavailability and Absorption

Tako, E. (2018) · MDPI eBooks · doi:10.3390/books978-3-03897-231-0 · Cited by 1

Selected molecular mechanisms of metal toxicity and carcinogenicity

Li, A. H., & Costa, M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823292-7.00008-5 · Cited by 1

Intestinal ferritinophagy is regulated by HIF-2α and is essential for systemic iron homeostasisPreprint

Das, N. K., Sankar, A. D., Schwartz, A. J., Solanki, S. A., Ma, X., Parimi, S., Santana-Codina, N., Mancias, J. D., & Shah, Y. M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.01.364059 · Cited by 1

The Regulation and Expression of Hepcidin in Carcinogenesis as a Result of Iron Overload Disorders: An Extended Literature Review

White, J. A. (2015) · Journal of Cancer Prevention & Current Research · doi:10.15406/jcpcr.2015.03.00077

Iron, Cancer, and Hypoxia-Inducible Factor Signaling

Xue, X., & Shah, Y. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802168-2.00017-8

The Role of Oxygen as a Stressor, Metabolite and Signalling Molecule and its Effect on Cell Proliferation

Franklin, E. R. (2018) · Queensland University of Technology · doi:10.5204/thesis.eprints.121736

Sport and Gender

Trevisani, F., & Villa, F. D. (2019) · Springer eBooks · doi:10.1007/978-3-030-15038-9_12

Correlation of EPO gene polymorphism with gestational diabetes mellitus

Zhang, H., Yanyan, J. I. N. G., Yongjiao, W. A. N. G., Bai, S., Yu, J., & Cao, Y. (2021) · Panminerva Medica · doi:10.23736/s0031-0808.19.03671-1

Influencia de las hormonas sexuales en la respuesta de la hepcidina y la homeostasis del hierro al ejercicio de resistencia en mujeres deportistas: Proyecto IronFEMME = Influence of sex hormones on the hepcidin and iron homeostasis response to endurance exercise in women athletes: IronFEMME study

Alfaro-Magallanes, V. M. (2022) · UPM Digital Archive (Technical University of Madrid) · doi:10.20868/upm.thesis.71841

Porfirias hereditarias en niños

Poli, A., Schmitt, C., Lefèbvre, T., Puy, H., & Gouya, L. (2022) · EMC - Pediatría · doi:10.1016/s1245-1789(22)47082-x

Iron deficiency in chronic kidney disease and the new generation of intravenous iron

Zhao, C. (2023) · Frontiers in Medical Science Research · doi:10.25236/fmsr.2023.050403

Anemia in ESKD

Małyszko, J. (2023) · Nephrology Self-Assessment Program · doi:10.58483/nsap.00142023

Diabetes and Hemochromatosis

Maggi, D. C., Aleo, A., Briatore, L., Mazzucchelli, C., Fontana, L., & Cordera, R. (2018) · American Diabetes Association eBooks · doi:10.2337/9781580406666.case34

Iron Dyshomeostasis in Schizophrenia and Potential Treatments to Mitigate Its Effects

Okafor, S. (2024) · Royal Society of Chemistry eBooks · doi:10.1039/9781837672059-00080

Case Studies

(2018) · American Diabetes Association eBooks · doi:10.2337/9781580406666.partii-ii

Critical Roles of Klebsiella pneumoniae Enterobactin in NLRP3 Inflammasome Activation in Airway Epithelial Cells

Verlaguet, J., Balestrino, D., Nakusi, L., Forestier, C., & Vareille-Delarbre, M. (2025) · Cellular Microbiology · doi:10.1155/cmi/6397050

Myoglobin leaching into the serum of IDA mice is driven by the high activation of sGC under anemic conditions which induces myoglobin expressionPreprint

Ghosh, A., Das, N. K., Sumi, M. P., Tupta, B., Ghosh, C., Stuehr, D. J., & Shah, Y. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.03.680120

Computational Analysis of Iron-binding Proteins in the Mutational Landscape of Cancer

Chauhan, S., Kulharia, M., & Verma, S. K. (2025) · Biological Trace Element Research · doi:10.1007/s12011-025-04881-x

Integrative hypoxia preconditioning: linking iron– hypoxia-inducible factor pathways and oxygen-based therapies from high-altitude physiology to clinical application: a comprehensive review

Singha, S., Ranjan, V., & Akhtar, K. (2025) · International Journal of Basic & Clinical Pharmacology · doi:10.18203/2319-2003.ijbcp20254173

Vitamin B6 deficiency anemia resembles iron-deficiency anemia but does not activate intestinal HIF2⍺

Alexopoulos, A., Nahiyan, R., Swaminathan, T., Roddur, S., Das, N. K., & Shah, Y. M. (2026) · Experimental Hematology · doi:10.1016/j.exphem.2025.105367

High-Altitude Condition Induces Hepatic Magnetic Susceptibility Changes and Liver Injury

Zhou, X., Feng, C., Fu, J., Zhang, L., Song, C., Wang, J., Chen, L., & Zhang, X. (2026) · Biomolecules · doi:10.3390/biom16030353

Ferritin in motion: How systemic iron balance and tumor trafficking shape glioblastoma

Tufano, E., & Connor, J. R. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189573 · Cited by 1

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