Role of the hypoxia inducible factors HIF in iron metabolism
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Iron is an essential element in all living organisms and is required as a cofactor for oxygen-binding proteins. Iron metabolism, oxygen homeostasis and erythropoiesis are consequently strongly interconnected. Iron needs to be tightly regulated, as iron insufficiency induces a hypoferric anemia in mammals, coupled to hypoxia in tissues, whereas excess iron is toxic, and causes generation of free radicals. Given the links between oxygen transport and iron metabolism, associations between the physiology of hypoxic response, and the control of iron availability are important. Numerous lines of investigation have proven that the HIF transcription factors function as central mediators of cellular adaptation to critically low oxygen levels in both normal and compromised tissues. Several of these target genes are involved in iron homeostasis, reflecting the molecular links between oxygen homeostasis and iron metabolism.
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HIF effects (via hepcidin) mobilisation of iron and can cause expression of inflammatory cytokines such as IL-1, IL-6 and TNF-α under hypoxia, and consequently increases sepsis (HIF-knockout mice are resistant to LPS-induced sepsis).
“In particular, HIF effects (via hepcidin) the mobilisation or iron and can cause the expression of inflammatory cytokines such as IL-1, IL-6 and TNF-α [2254-2256] under conditions (hypoxia) where superoxide and peroxide production are likely to be increased, and consequently increases sepsis (in that HIF-knockout mice are resistant to LPS-induced sepsis [2254,2255]).”
From Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases (2009) · cites this paper as [2256]
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- Authors
- Peyssonnaux, C., Nizet, V., & Johnson, R. S.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- University of California San Diego (US)
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2008-01
- Volume
- 7
- Issue
- 1
- Pages
- 28-32
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- OpenAlex
- W2116991069
- Cited by
- 217
- References
- 47
- Citations by year
- 2026: 10 · 2025: 10 · 2024: 8 · 2023: 13 · 2022: 9 · 2021: 19 · 2020: 22 · 2019: 12 · 2018: 10 · 2017: 11 · 2016: 14 · 2015: 8 · 2014: 8 · 2013: 8 · 2012: 7
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cell Cycle (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- hypoxia-inducible factor, iron metabolism, iron homeostasis, oxygen homeostasis, erythropoiesis, iron deficiency, iron overload, oxidative stress, hypoxia response, transcription factors
- MeSH terms
- Animals, Homeostasis, Humans, Iron, Oxygen Consumption, Signal Transduction, Cell Hypoxia, Basic Helix-Loop-Helix Proteins, Hypoxia-Inducible Factor 1, alpha Subunit
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