Cited by 187Erythropoietin and Anemia TreatmentIron Metabolism and DisordersHemoglobin structure and function

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Hypoxia-Inducible Factors Link Iron Homeostasis and Erythropoiesis

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Shah, Yatrik M., Xie, Liwei·2014·Gastroenterology

DOI 10.1053/j.gastro.2013.12.031PMC PMC3943938

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Abstract

Iron is required for efficient oxygen transport, and hypoxia signaling links erythropoiesis with iron homeostasis. Hypoxia induces a highly conserved signaling pathway in cells under conditions of low levels of O2. One component of this pathway, hypoxia-inducible factor (HIF), is a transcription factor that is highly active in hypoxic cells. The first HIF target gene characterized was EPO, which encodes erythropoietin-a glycoprotein hormone that controls erythropoiesis. In the past decade, there have been fundamental advances in our understanding of how hypoxia regulates iron levels to support erythropoiesis and maintain systemic iron homeostasis. We review the cell type-specific effects of hypoxia and HIFs in adaptive response to changes in oxygen and iron availability as well as potential uses of HIF modulators for patients with iron-related disorders.

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Authors: Shah, Y. M., & Xie, L.
Affiliations: University of Michigan (US)
Corresponding author: Shah, Yatrik M.
ORCID: Shah, Yatrik M.
Xie, Liwei
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2014-03
Volume: 146
Issue: 3
Pages: 630-642
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/j.gastro.2013.12.031
PMC: PMC3943938
OpenAlex: W2168760727
Cited by: 187
References: 145
Citations by year: 2026: 18 · 2025: 14 · 2024: 23 · 2023: 19 · 2022: 22 · 2021: 22 · 2020: 15 · 2019: 12 · 2018: 11 · 2017: 9 · 2016: 7 · 2015: 11 · 2014: 4
FWCI: 1.58
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: University of Michigan
National Institutes of Health
University of Michigan Comprehensive Cancer Center
National Cancer Institute (CA148828, R01CA148828)
National Institute of Diabetes and Digestive and Kidney Diseases (DK-095201, R01DK095201)
Topics: Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
Keywords: hypoxia-inducible factor, iron homeostasis, erythropoiesis, erythropoietin, hypoxia signaling, oxygen availability
MeSH terms: Endothelial PAS Domain-Containing Protein 1, Hypoxia, Erythropoiesis, Erythropoietin, Homeostasis, Humans, Iron, Liver, Oxygen, Signal Transduction, Basic Helix-Loop-Helix Proteins, Hypoxia-Inducible Factor 1

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Hypoxia-Inducible Factors Link Iron Homeostasis and Erythropoiesis

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