The DOI matches its Crossref record; 143 of the 145 references it cites were found in a registry or an index.
Hypoxia-Inducible Factors Link Iron Homeostasis and Erythropoiesis
Open accessAbstract
Iron is required for efficient oxygen transport, and hypoxia signaling links erythropoiesis with iron homeostasis. Hypoxia induces a highly conserved signaling pathway in cells under conditions of low levels of O2. One component of this pathway, hypoxia-inducible factor (HIF), is a transcription factor that is highly active in hypoxic cells. The first HIF target gene characterized was EPO, which encodes erythropoietin-a glycoprotein hormone that controls erythropoiesis. In the past decade, there have been fundamental advances in our understanding of how hypoxia regulates iron levels to support erythropoiesis and maintain systemic iron homeostasis. We review the cell type-specific effects of hypoxia and HIFs in adaptive response to changes in oxygen and iron availability as well as potential uses of HIF modulators for patients with iron-related disorders.
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“IRP1-mediated suppression of HIF-2α translation prevents HIF-2 mediated induction of erythropoiesis under iron starvation conditions, when the production of hemoglobin, an iron-containing molecule, may be limiting [23].”
From The HIF Axes in Cancer - Angiogenesis, Metabolism and Immune-Modulation (2025) · cites this paper as [23]
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Iron homeostasis during pregnancy
Fisher, A. L., & Nemeth, E. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.117.155812 · Cited by 432
Singhal, R., & Shah, Y. M. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.011188 · Cited by 401
Self-citationThe IRP/IRE system in vivo: insights from mouse models
Wilkinson, N., & Pantopoulos, K. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00176 · Cited by 366
The physiological functions of iron regulatory proteins in iron homeostasis - an update
Zhang, D., Ghosh, M. C., & Rouault, T. A. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00124 · Cited by 310
Metadata
- Authors
- Shah, Y. M., & Xie, L.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Shah, Yatrik M.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 146
- Issue
- 3
- Pages
- 630-642
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC3943938
- OpenAlex
- W2168760727
- Cited by
- 187
- References
- 145
- Citations by year
- 2026: 18 · 2025: 14 · 2024: 23 · 2023: 19 · 2022: 22 · 2021: 22 · 2020: 15 · 2019: 12 · 2018: 11 · 2017: 9 · 2016: 7 · 2015: 11 · 2014: 4
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Michigan
- National Institutes of Health
- University of Michigan Comprehensive Cancer Center
- National Cancer Institute (CA148828, R01CA148828)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-095201, R01DK095201)
- Topics
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Keywords
- hypoxia-inducible factor, iron homeostasis, erythropoiesis, erythropoietin, hypoxia signaling, oxygen availability
- MeSH terms
- Endothelial PAS Domain-Containing Protein 1, Hypoxia, Erythropoiesis, Erythropoietin, Homeostasis, Humans, Iron, Liver, Oxygen, Signal Transduction, Basic Helix-Loop-Helix Proteins, Hypoxia-Inducible Factor 1
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