Cited by 421Gut microbiota and healthAdipokines, Inflammation, and Metabolic DiseasesGastrointestinal motility and disorders

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Role of the Microbiome in Energy Regulation and Metabolism

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Nieuwdorp, Max, Gilijamse, Pim W., Pai, Nikhil, Kaplan, Lee M.·2014·Gastroenterology

DOI 10.1053/j.gastro.2014.02.008

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Abstract

Intestinal microbes regulate metabolic function and energy balance; an altered microbial ecology is believed to contribute to the development of several metabolic diseases. Relative species abundance and metabolic characteristics of the intestinal microbiota change substantially in those who are obese or have other metabolic disorders and in response to ingested nutrients or therapeutic agents. The mechanisms through which the intestinal microbiota and its metabolites affect host homeostasis are just beginning to be understood. We review the relationships between the intestinal microbiota and host metabolism, including energy intake, use, and expenditure, in relation to glucose and lipid metabolism. These associations, along with interactions among the intestinal microbiota, mucus layer, bile acids, and mucosal immune responses, reveal potential mechanisms by which the microbiota affect metabolism. We discuss how controlled studies involving direct perturbations of microbial communities in human and animal models are required to identify effective therapeutic targets in the microbiota.

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Authors: Nieuwdorp, M., Gilijamse, P. W., Pai, N., & Kaplan, L. M.
Affiliations: Amsterdam UMC Location University of Amsterdam (NL)
Boston Children's Hospital (US)
Harvard University (US)
Corresponding author: Nieuwdorp, Max
Kaplan, Lee M.
ORCID: Nieuwdorp, Max
Pai, Nikhil
Kaplan, Lee M.
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2014-05
Volume: 146
Issue: 6
Pages: 1525-1533
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/j.gastro.2014.02.008
OpenAlex: W1980143346
Cited by: 421
References: 76
Citations by year: 2026: 14 · 2025: 23 · 2024: 32 · 2023: 34 · 2022: 43 · 2021: 56 · 2020: 30 · 2019: 39 · 2018: 35 · 2017: 30 · 2016: 36 · 2015: 32 · 2014: 17
FWCI: 3.61
Type: journal article
Language: en
Open access: green
zenodo.org
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK-088661, RC2DK088661, P30DK040561)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: gut microbiota, energy balance, host metabolism, obesity, metabolic disorders, glucose metabolism, lipid metabolism, bile acids, mucus layer, mucosal immune response, microbial metabolites, therapeutic target
MeSH terms: Animals, Bacteria, Bile Acids and Salts, Diabetes Mellitus, Energy Metabolism, Gastrointestinal Diseases, Homeostasis, Humans, Intestinal Mucosa, Intestines, Obesity, Probiotics, Host-Pathogen Interactions, Microbiota

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