Cited by 421Gut microbiota and healthAdipokines, Inflammation, and Metabolic DiseasesGastrointestinal motility and disorders

The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.

Role of the Microbiome in Energy Regulation and Metabolism

Open access

Nieuwdorp, Max, Gilijamse, Pim W., Pai, Nikhil, Kaplan, Lee M.·2014·Gastroenterology

DOI 10.1053/j.gastro.2014.02.008

Open this paper in CoChat — free account

Abstract

Intestinal microbes regulate metabolic function and energy balance; an altered microbial ecology is believed to contribute to the development of several metabolic diseases. Relative species abundance and metabolic characteristics of the intestinal microbiota change substantially in those who are obese or have other metabolic disorders and in response to ingested nutrients or therapeutic agents. The mechanisms through which the intestinal microbiota and its metabolites affect host homeostasis are just beginning to be understood. We review the relationships between the intestinal microbiota and host metabolism, including energy intake, use, and expenditure, in relation to glucose and lipid metabolism. These associations, along with interactions among the intestinal microbiota, mucus layer, bile acids, and mucosal immune responses, reveal potential mechanisms by which the microbiota affect metabolism. We discuss how controlled studies involving direct perturbations of microbial communities in human and animal models are required to identify effective therapeutic targets in the microbiota.

Integrity signals

Registry

Crossref · 10.1053/j.gastro.2014.02.008

Cites

76 of 76 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance
Tsukumo, D. M. L., Carvalho-Filho, M. A., Carvalheira, J. B. C., Prada, P. O., Hirabara, S. M., Schenka, A. A., Araújo, E. P., Vassallo, J., Curi, R., Velloso, L. A., et al. (2007) · Diabetes · doi:10.2337/db06-1595 · Cited by 826
Retracted
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
A metagenome-wide association study of gut microbiota in type 2 diabetes
Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638
Linking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513
The metabolic syndrome
Eckel, R. H., Alberti, K., Grundy, S. M., & Zimmet, P. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61794-3 · Cited by 6,317
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176

Flagged first, then by citations

Show all 76 references

Research works printed but not linked: 1

Cho, 2012, Antibiotics in early life alter the murine colonic microbiome and adiposity, Nature, 488, 621, 10.1038/nature11400 · DOI · Paper page

Sorted by citations

Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes
Riquelme, E., Zhang, Y., Zhang, L., Montiel, M., Zoltan, M., Dong, W., Quesada, P., Sahin, I., Chandra, V., San Lucas, A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.07.008 · Cited by 1,577
“It has been demonstrated that microbiota imbalances can induce systemic metabolic alterations (Devaraj et al., 2013; Nieuwdorp et al., 2014).”
Background
Gut microbiota induce IGF-1 and promote bone formation and growth
Yan, J., Herzog, J. W., Tsang, K., Brennan, C. A., Bower, M. A., Garrett, W. S., Sartor, B. R., Aliprantis, A. O., & Charles, J. F. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607235113 · Cited by 750
Akkermansia muciniphila is a promising probiotic
Zhang, T., Li, Q., Cheng, L., Buch, H., & Zhang, F. (2019) · Microbial Biotechnology · doi:10.1111/1751-7915.13410 · Cited by 708
Nutrients, foods, and colorectal cancer prevention
Song, M., Garrett, W. S., & Chan, A. T. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.12.035 · Cited by 700
Intestinal transport and metabolism of bile acids
Dawson, P. A., & Karpen, S. J. (2015) · Journal of Lipid Research · doi:10.1194/jlr.r054114 · Cited by 598
Patterned progression of bacterial populations in the premature infant gut
Rosa, P. S. L., Warner, B. B., Zhou, Y., Weinstock, G. M., Sodergren, E. J., Hall-Moore, C. M., Stevens, H. J., Bennett, W. E., Shaikh, N., Linneman, L. A., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409497111 · Cited by 586
Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism
Zarrinpar, A., Chaix, A., Xu, Z. Z., Chang, M. W., Marotz, C. A., Saghatelian, A., Knight, R., & Panda, S. (2018) · Nature Communications · doi:10.1038/s41467-018-05336-9 · Cited by 546
Transplantation of fecal microbiota from patients with irritable bowel syndrome alters gut function and behavior in recipient mice
De Palma, G., Lynch, M. D. J., Lu, J., Dang, V. T., Deng, Y., Jury, J., Umeh, G., Miranda, P. M., Pigrau Pastor, M., Sidani, S., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf6397 · Cited by 505
Effects of polystyrene microplastics on the composition of the microbiome and metabolism in larval zebrafish
Wan, Z., Wang, C., Zhou, J., Shen, M., Wang, X., Fu, Z., & Jin, Y. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.11.070 · Cited by 511
Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier
Zhou, D., Pan, Q., Xin, F.-Z., Zhang, R.-N., He, C.-X., Chen, G.-Y., Liu, C., Chen, Y.-W., & Fan, J.-G. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i1.60 · Cited by 441
Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415
The Influence of the Gut Microbiome on Host Metabolism Through the Regulation of Gut Hormone Release
Martin, A. M., Sun, E. W. L., Rogers, G. B., & Keating, D. J. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00428 · Cited by 402
The gut microbiome and diet in psychiatry: focus on depression
Dash, S., Clarke, G., Berk, M., & Jacka, F. N. (2015) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000117 · Cited by 369
Mushroom Polysaccharides: Chemistry and Antiobesity, Antidiabetes, Anticancer, and Antibiotic Properties in Cells, Rodents, and Humans
Friedman, M. (2016) · Foods · doi:10.3390/foods5040080 · Cited by 368
Dysbiosis of human gut microbiome in young-onset colorectal cancer
Yang, Y., Du, L., Shi, D., Kong, C., Liu, J., Liu, G., Li, X., & Ma, Y. (2021) · Nature Communications · doi:10.1038/s41467-021-27112-y · Cited by 303
Faecal microbiota transplantation protects against radiation‐induced toxicity
Cui, M., Xiao, H., Li, Y., Zhou, L., Zhao, S., Luo, D., Zheng, Q., Dong, J., Zhao, Y., Zhang, X., et al. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201606932 · Cited by 340
Gut Microbiota and Iron: The Crucial Actors in Health and Disease
Yilmaz, B., & Li, H. (2018) · Pharmaceuticals · doi:10.3390/ph11040098 · Cited by 317
The gut microbiota as a target to control hyperuricemia pathogenesis: Potential mechanisms and therapeutic strategies
Wang, J., Chen, Y., Zhong, H., Chen, F., Regenstein, J. M., Hu, X., Cai, L., & Feng, F. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1874287 · Cited by 322
Microbiota regulation of the mammalian gut-brain axis
Burokas, A., Moloney, R. D., Dinan, T. G., & Cryan, J. F. (2015) · Advances in applied microbiology · doi:10.1016/bs.aambs.2015.02.001 · Cited by 300
The gut microbiome and obesity
John, G. K., & Mullin, G. E. (2016) · Current Oncology Reports · doi:10.1007/s11912-016-0528-7 · Cited by 304
May the Force Be With You: The Light and Dark Sides of the Microbiota–Gut–Brain Axis in Neuropsychiatry
Sherwin, E., Sandhu, K. V., Dinan, T. G., & Cryan, J. F. (2016) · CNS Drugs · doi:10.1007/s40263-016-0370-3 · Cited by 309
Bifidobacterium alters the gut microbiota and modulates the functional metabolism of T regulatory cells in the context of immune checkpoint blockade
Sun, S., Luo, L., Liang, W., Yin, Q., Guo, J., Rush, A. M., Lv, Z., Liang, Q., Fischbach, M. A., Sonnenburg, J. L., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1921223117 · Cited by 277
Advances in low-protein diets for swine
Wang, Y., Zhou, J., Wang, G., Cai, S., Zeng, X., & Qiao, S. (2018) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-018-0276-7 · Cited by 292
Development of the preterm infant gut microbiome: a research priority
Groer, M. W., Luciano, A. A., Dishaw, L. J., Ashmeade, T. L., Miller, E. M., & Gilbert, J. A. (2014) · Microbiome · doi:10.1186/2049-2618-2-38 · Cited by 302
Effects of probiotics on body weight, body mass index, fat mass and fat percentage in subjects with overweight or obesity: A systematic review and meta-analysis of randomized controlled trials
Borgeraas, H., Johnson, L. K., Skattebu, J., Hertel, J. K., & Hjelmesæth, J. (2018) · Obesity Reviews · doi:10.1111/obr.12626 · Cited by 278
The Mouse Microbiome Is Required for Sex-Specific Diurnal Rhythms of Gene Expression and Metabolism
Weger, B. D., Gobet, C., Yeung, J., Martin, E., Jimenez, S., Betrisey, B., Foata, F., Berger, B., Balvay, A., Foussier, A., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.09.023 · Cited by 269
Alteration of the gut microbiota in Chinese population with chronic kidney disease
Jiang, S., Xie, S., Lv, D., Wang, P., He, H., Zhang, T., Zhou, Y., Lin, Q., Zhou, H., Jiang, J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-02989-2 · Cited by 269
The diverse metabolic roles of peripheral serotonin
Martin, A. M., Young, R. L., Leong, L., Rogers, G. B., Spencer, N. J., Jessup, C. F., & Keating, D. J. (2017) · Endocrinology · doi:10.1210/en.2016-1839 · Cited by 261
Comparison of the gut microbial community between obese and lean peoples using 16S gene sequencing in a Japanese population
Andoh, A., Nishida, A., Takahashi, K., Inatomi, O., Imaeda, H., Bamba, S., Kito, K., Sugimoto, M., & Kobayashi, T. (2016) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.15-152 · Cited by 263
Understanding the growing epidemic of type 2 diabetes in the Hispanic population living in the United States
Aguayo‐Mazzucato, C., Diaque, P., Hernandez, S. L., Rosas, S., Kostic, A. D., & Caballero, A. E. (2018) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3097 · Cited by 263
Expanded catalog of microbial genes and metagenome-assembled genomes from the pig gut microbiome
Chen, C., Zhou, Y., Fu, H., Xiong, X., Fang, S., Jiang, H., Wu, J., Yang, H., Gao, J., & Huang, L. (2021) · Nature Communications · doi:10.1038/s41467-021-21295-0 · Cited by 249
Inflammatory Bowel Diseases and Gut Microbiota
Haneishi, Y., Furuya, Y., Hasegawa, M., Picarelli, A., Rossi, M., & Miyamoto, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043817 · Cited by 263
Diet, genetics, and the gut microbiome drive dynamic changes in plasma metabolites
Fujisaka, S., Avila-Pacheco, J., Soto, M., Kostic, A., Dreyfuss, J. M., Pan, H., Ussar, S., Altindis, E., Li, N., Bry, L., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.060 · Cited by 231
“There are many classes of bacterial metabolites in addition to bile acids that can be modified by factors such as diet and antibiotic treatment (Brown and Hazen, 2017; Nieuwdorp et al., 2014).”
Background
Influence of Diet and Nutrition on Prostate Cancer
Matsushita, M., Fujita, K., & Nonomura, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041447 · Cited by 244
Insulin action at a molecular level – 100 years of progress
White, M. F., & Kahn, C. R. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101304 · Cited by 221
Dietary fat and gut microbiota interactions determine diet-induced obesity in mice
Kübeck, R., Bonet-Ripoll, C., Hoffmann, C., Walker, A., Müller, V. M., Schüppel, V. L., Lagkouvardos, I., Scholz, B., Engel, K.-H., Daniel, H., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.10.001 · Cited by 211
Towards a multidisciplinary approach to understand and manage obesity and related diseases
Bischoff, S. C., Boirie‌, Y., Cederholm, T., Chourdakis, M., Cuerda, C., Delzenne, N. M., Deutz, N. E. P., Fouque, D. P., Genton, L., Gil, C., et al. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.11.007 · Cited by 223
Inulin supplementation ameliorates hyperuricemia and modulates gut microbiota in Uox-knockout mice
Guo, Y., Yu, Y., Li, H., Ding, X., Li, X., Jing, X., Chen, J., Liu, G., Lin, Y., Jiang, C., et al. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02414-x · Cited by 203
Butyrate Shapes Immune Cell Fate and Function in Allergic Asthma
Yip, W., Hughes, M. R., Li, Y., Cait, A., Hirst, M., Mohn, W. W., & McNagny, K. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.628453 · Cited by 197
Targeting fatty acid metabolism to improve glucose metabolism
Stinkens, R., Goossens, G. H., Jocken, J. W. E., & Blaak, E. E. (2015) · Obesity Reviews · doi:10.1111/obr.12298 · Cited by 183
The intestinal microbiome and health
Tuddenham, S., & Sears, C. L. (2015) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000196 · Cited by 188
Chlorogenic acid supplementation ameliorates hyperuricemia, relieves renal inflammation, and modulates intestinal homeostasis
Zhou, X., Zhang, B., Zhao, X., Lin, Y., Wang, J., Wang, X., Hu, N., & Wang, S. (2021) · Food & Function · doi:10.1039/d0fo03199b · Cited by 186
Eubiotic properties of rifaximin: Disruption of the traditional concepts in gut microbiota modulation
Ponziani, F. R., Zocco, M. A., D’Aversa, F., Pompili, M., & Gasbarrini, A. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i25.4491 · Cited by 177
Recent findings in Akkermansia muciniphila-regulated metabolism and its role in intestinal diseases
Liu, M., Yang, J.-Y., Yan, Z.-H., Hu, S., Li, J.-Q., Xu, Z., & Jian, Y. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.08.029 · Cited by 176
Flaxseed Lignans as Important Dietary Polyphenols for Cancer Prevention and Treatment: Chemistry, Pharmacokinetics, and Molecular Targets
Silva, F. D., & Alcorn, J. (2019) · Pharmaceuticals · doi:10.3390/ph12020068 · Cited by 168
Probiotics for weight loss: a systematic review and meta-analysis
Park, S., & Bae, J.-H. (2015) · Nutrition Research · doi:10.1016/j.nutres.2015.05.008 · Cited by 167
Dysbiosis in gastrointestinal disorders
Chang, C., & Lin, H. C. (2016) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2016.02.001 · Cited by 163
Characterization of the salivary microbiome in people with obesity
Wu, Y., Chi, X., Zhang, Q., Chen, F., & Deng, X. (2018) · PeerJ · doi:10.7717/peerj.4458 · Cited by 158
Of the bugs that shape us: maternal obesity, the gut microbiome, and long-term disease risk
Gohir, W., Ratcliffe, E. M., & Sloboda, D. M. (2014) · Pediatric Research · doi:10.1038/pr.2014.169 · Cited by 150
Histological improvement of non-alcoholic steatohepatitis with a prebiotic: a pilot clinical trial
Bomhof, M. R., Parnell, J. A., Ramay, H. R., Crotty, P., Rioux, K. P., Probert, C. S., Jayakumar, S., Raman, M., & Reimer, R. A. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1721-2 · Cited by 148
Dietary Alteration of the Gut Microbiome and Its Impact on Weight and Fat Mass: A Systematic Review and Meta-Analysis
John, G. K., Wang, L., Nanavati, J., Twose, C., Singh, R., & Mullin, G. E. (2018) · Genes · doi:10.3390/genes9030167 · Cited by 151
The Role of the Intestine in the Development of Hyperuricemia
Yin, H., Liu, N., & Chen, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.845684 · Cited by 151
Alistipes indistinctus-derived hippuric acid promotes intestinal urate excretion to alleviate hyperuricemia
Xu, Y., Liu, L., Zhu, J.-Y., Zhu, S., Ye, B., Yang, J.-L., Huang, J.-Y., Huang, Z.-H., You, Y., Li, W., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.02.001 · Cited by 152
Diversity of Duodenal and Rectal Microbiota in Biopsy Tissues and Luminal Contents in Healthy Volunteers
Li, G., Yang, M. J., Zhou, K., Zhang, L., Tian, L., Lv, S., Jin, Y. T., Qian, W., Xiong, H., Lin, R., et al. (2015) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1412.12047 · Cited by 146
Bacterial bile salt hydrolase in host metabolism: potential for influencing gastrointestinal microbe-host crosstalk
Joyce, S. A., Shanahan, F., Hill, C., & Gahan, C. G. (2014) · Gut Microbes · doi:10.4161/19490976.2014.969986 · Cited by 139
Food additives: Assessing the impact of exposure to permitted emulsifiers on bowel and metabolic health – introducing the FADiets study
Partridge, D., Lloyd, K., Rhodes, J. M., Walker, A. W., Johnstone, A. M., & Campbell, B. J. (2019) · Nutrition Bulletin · doi:10.1111/nbu.12408 · Cited by 154
Long-Term Change in Diet Quality Is Associated with Body Weight Change in Men and Women
Fung, T. T., Pan, A., Hou, T., Chiuve, S. E., Tobias, D. K., Mozaffarian, D., Willett, W. C., & Hu, F. B. (2015) · Journal of Nutrition · doi:10.3945/jn.114.208785 · Cited by 133
Association Between Gut Microbiota and Elevated Serum Urate in Two Independent Cohorts
Wei, J., Zhang, Y., Dalbeth, N., Terkeltaub, R. A., Yang, T., Wang, Y., Yang, Z., Li, J., Wu, Z., Zeng, C., et al. (2021) · Arthritis & Rheumatology · doi:10.1002/art.42009 · Cited by 133
Alterations of the Gut Microbiome Associated With the Treatment of Hyperuricaemia in Male Rats
Yu, Y., Liu, Q., Li, H., Wen, C., & He, Z. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02233 · Cited by 129
Gut Microbiota as an Objective Measurement for Auxiliary Diagnosis of Insomnia Disorder
Liu, B., Lin, W., Chen, S., Xiang, T., Yang, Y., Yin, Y., Xu, G., Liu, Z., Liu, L., Pan, J., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01770 · Cited by 132
Treating Obesity and Metabolic Syndrome with Fecal Microbiota Transplantation.
Marotz, C. A., & Zarrinpar, A. (2016) · PubMed · Cited by 128
Fecal transplantation and butyrate improve neuropathic pain, modify immune cell profile, and gene expression in the PNS of obese mice
Bonomo, R. R., Cook, T. M., Gavini, C. K., White, C. R., Jones, J. R., Bovo, E., Zima, A. V., Brown, I. A., Dugas, L. R., Zakharian, E., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2006065117 · Cited by 114
Microbial osteoporosis: The interplay between the gut microbiota and bones via host metabolism and immunity
Li, L., Rao, S., Cheng, Y., Zhuo, X., Deng, C., Xu, N., Zhang, H., & Yang, L. (2019) · MicrobiologyOpen · doi:10.1002/mbo3.810 · Cited by 109
Protective effects of tuna meat oligopeptides (TMOP) supplementation on hyperuricemia and associated renal inflammation mediated by gut microbiota
Han, J., Wang, X., Tang, S., Lu, C., Wan, H., Zhou, J., Li, Y., Ming, T., Wang, Z. J., & Su, X. (2020) · The FASEB Journal · doi:10.1096/fj.201902597rr · Cited by 110
Human oral microbiome dysbiosis as a novel non-invasive biomarker in detection of colorectal cancer
Zhang, S., Kong, C., Yang, Y. P., Cai, S., Li, X., Cai, G., & Ma, Y. (2020) · Theranostics · doi:10.7150/thno.49515 · Cited by 113
Gut microbiome and bone: To build, destroy, or both?
Yan, J., & Charles, J. F. (2017) · Current Osteoporosis Reports · doi:10.1007/s11914-017-0382-z · Cited by 108
Systematic Analysis of the Association between Gut Flora and Obesity through High-Throughput Sequencing and Bioinformatics Approaches
Chiu, C.-M., Huang, W.-C., Weng, S.-L., Tseng, H., Liang, C., Wang, W.-C., Yang, T., Yang, T.-L., Weng, C.-T., Chang, T., et al. (2014) · BioMed Research International · doi:10.1155/2014/906168 · Cited by 110
Is there a role for gut microbiota in type 1 diabetes pathogenesis?
Bibbò, S., Dore, M. P., Pes, G. M., Delitala, G., & Delitala, A. (2016) · Annals of Medicine · doi:10.1080/07853890.2016.1222449 · Cited by 109
Cognitive and autonomic determinants of energy homeostasis in obesity
Richard, D. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.103 · Cited by 113
Secular differences in the association between caloric intake, macronutrient intake, and physical activity with obesity
Brown, R. E., Sharma, A. M., Ardern, C. I., Mirdamadi, P., Mirdamadi, P., & Kuk, J. L. (2015) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2015.08.007 · Cited by 109
Comparisons of protective effects between two sea cucumber hydrolysates against diet induced hyperuricemia and renal inflammation in mice
Wan, H., Han, J., Tang, S., Bao, W., Lu, C., Zhou, J., Ming, T., Li, Y., & Su, X. (2019) · Food & Function · doi:10.1039/c9fo02425e · Cited by 107
The Gut Microbiome in Health and Disease
Owyang, C., & Wu, G. D. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.03.032 · Cited by 118
Gut microbiota modulates alcohol withdrawal-induced anxiety in mice
Xiao, H.-W., Ge, C., Feng, G.-X., Li, Y., Luo, D., Dong, J.-L., Li, H., Wang, H., Cui, M., & Fan, S.-J. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.01.021 · Cited by 102
Dietary and Lifestyle Factors Associated with Colorectal Cancer Risk and Interactions with Microbiota: Fiber, Red or Processed Meat and Alcoholic Drinks
Tuan, J., & Chen, Y. (2015) · Gastrointestinal Tumors · doi:10.1159/000442831 · Cited by 107
Sediment bacteria in an urban stream: Spatiotemporal patterns in community composition
Roberto, A. A., Gray, J. B. V., & Leff, L. G. (2018) · Water Research · doi:10.1016/j.watres.2018.01.045 · Cited by 95
Gut microbiome: a new player in gastrointestinal disease
Gorkiewicz, G., & Moschen, A. R. (2017) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-017-2277-x · Cited by 95
Environmentally relevant concentrations of microplastics influence the locomotor activity of aquatic biota
Sun, T., Zhan, J., Li, F., Ji, C., & Wu, H. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.125581 · Cited by 88
Fucoidan as a marine-origin prebiotic modulates the growth and antibacterial ability of Lactobacillus rhamnosus
Zhu, Y., Liu, L., Sun, Z., Ji, Y., Wang, D., Mei, L., Shen, P., Li, Z., Tang, S., Zhang, H., et al. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.03.065 · Cited by 87
Gut Microbiota as a Driver of Inflammation in Nonalcoholic Fatty Liver Disease
Bibbò, S., Ianiro, G., Dore, M. P., Simonelli, C., Newton, E. E., & Cammarota, G. (2018) · Mediators of Inflammation · doi:10.1155/2018/9321643 · Cited by 88
Competition among Nasal Bacteria Suggests a Role for Siderophore-Mediated Interactions in Shaping the Human Nasal Microbiota
Stubbendieck, R. M., May, D. S., Chevrette, M. G., Temkin, M. I., Wendt-Pienkowski, E., Cagnazzo, J., Carlson, C. M., Gern, J. E., & Currie, C. R. (2018) · Applied and Environmental Microbiology · doi:10.1128/aem.02406-18 · Cited by 86
Effect of antenatal dietary interventions in maternal obesity on pregnancy weight-gain and birthweight: Healthy Mums and Babies (HUMBA) randomized trial
Okesene-Gafa, K. A. M., Li, M., McKinlay, C. J. D., Taylor, R. S., Rush, E. C., Wall, C. R., Wilson, J., Murphy, R., Taylor, R. W., Thompson, J., et al. (2019) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2019.03.003 · Cited by 89
Molecular and Pathophysiological Links between Metabolic Disorders and Inflammatory Bowel Diseases
Hyun, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179139 · Cited by 87
The role of obesity in oesophageal cancer development
Long, E., & Beales, I. (2014) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x14538689 · Cited by 81
Obesity in school-aged children and its correlation with Gut E.coli and Bifidobacteria: a case–control study
Gao, X., Jia, R., Xie, L., Kuang, L., Feng, L., & Wan, C. (2015) · BMC Pediatrics · doi:10.1186/s12887-015-0384-x · Cited by 82
Early Antibiotic Exposure and Weight Outcomes in Young Children
Block, J. P., Bailey, L. C., Gillman, M. W., Lunsford, D., Daley, M. F., Eneli, I., Finkelstein, J. A., Heerman, W. J., Horgan, C. E., Hsia, D. S., et al. (2018) · PEDIATRICS · doi:10.1542/peds.2018-0290 · Cited by 78
Sulforaphane-driven reprogramming of gut microbiome and metabolome ameliorates the progression of hyperuricemia
Wang, R., Halimulati, M., Huang, X., Ma, Y., Li, L., & Zhang, Z. (2022) · Journal of Advanced Research · doi:10.1016/j.jare.2022.11.003 · Cited by 78
Developmental responses to early‐life adversity: Evolutionary and mechanistic perspectives
Lu, A., Petrullo, L. A., Carrera, S. C., Feder, J. A., Schneider‐Crease, I. A., & Snyder‐Mackler, N. (2019) · Evolutionary Anthropology Issues News and Reviews · doi:10.1002/evan.21791 · Cited by 78
Helicobacter pyloriinfection is not associated with nonalcoholic fatty liver disease
Baeg, M. K. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i8.2592 · Cited by 76
Theabrownin from Fu Brick Tea Improves Ulcerative Colitis by Shaping the Gut Microbiota and Modulating the Tryptophan Metabolism
Yang, W., Ren, D., Shao, H., Zhang, X., Li, T., Zhang, L., Liu, L., Zhao, Y., Niu, P., & Yang, X. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c06821 · Cited by 76
The Significance of the Enteric Microbiome on the Development of Childhood Disease: A Review of Prebiotic and Probiotic Therapies in Disorders of Childhood
Slattery, J. M., MacFabe, D. F., & Frye, R. E. (2016) · Clinical Medicine Insights Pediatrics · doi:10.4137/cmped.s38338 · Cited by 72
Akkermansia supplementation reverses the tumor-promoting effect of the fecal microbiota transplantation in ovarian cancer
Wang, Z., Qin, X., Hu, D., Huang, J. M., Guo, E., Xiao, R., Li, W., Sun, C., & Chen, G. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111890 · Cited by 72
Impact of Camellia japonica Bee Pollen Polyphenols on Hyperuricemia and Gut Microbiota in Potassium Oxonate-Induced Mice
Xu, Y., Cao, X., Zhao, H., Yang, E., Wang, Y., Cheng, N., & Cao, W. (2021) · Nutrients · doi:10.3390/nu13082665 · Cited by 71
Mixed Viral-Bacterial Infections and Their Effects on Gut Microbiota and Clinical Illnesses in Children
Mathew, S., Smatti, M. K., Alansari, K., Nasrallah, G. K., Thani, A. A. A., & Yassine, H. M. (2019) · Scientific Reports · doi:10.1038/s41598-018-37162-w · Cited by 73
Dairy probiotics: Beyond the role of promoting gut and immune health
Ζουμποπούλου, Γ., Pot, B., Tsakalidou, E., & Papadimitriou, K. (2016) · International Dairy Journal · doi:10.1016/j.idairyj.2016.09.010 · Cited by 74
Prebiotic milk oligosaccharides prevent development of obese phenotype, impairment of gut permeability, and microbial dysbiosis in high fat-fed mice
Hamilton, M. K., Ronveaux, C. C., RUST, B. M., Newman, J. W. I., Hawley, M. M., Barile, D., Mills, D. A., & Raybould, H. E. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00427.2016 · Cited by 70
Multiomics Approach to Explore the Amelioration Mechanisms of Glucomannans on the Metabolic Disorder of Type 2 Diabetic Rats
Chen, H., Nie, Q., Hu, J., Huang, X., Yin, J., & Nie, S. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c07871 · Cited by 69
Folic Acid Protects against Hyperuricemia in C57BL/6J Mice via Ameliorating Gut–Kidney Axis Dysfunction
Wang, P., Zhang, X., Zheng, X., Gao, J., Shang, M., Xu, J., & Liang, H. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c06297 · Cited by 71
Microbes and Oxytocin
Erdman, S. E., & Poutahidis, T. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.07.004 · Cited by 69
Characterization of the Esophageal Microbiota and Prediction of the Metabolic Pathways Involved in Esophageal Cancer
Li, D., He, R., Hou, G., Ming, W., Fan, T. T., Chen, L., Zhang, L., Jiang, W., Wang, W., Lu, Z., et al. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00268 · Cited by 65
Alteration of Gut Microbiota After Antibiotic Exposure in Finishing Swine
Jo, H. E., Kwon, M., Whon, T. W., Kim, D. W., Yun, M., Lee, J., Shin, M., Kim, S.-H., & Choi, H. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.596002 · Cited by 68

Authors: Nieuwdorp, M., Gilijamse, P. W., Pai, N., & Kaplan, L. M.
Affiliations: Amsterdam UMC Location University of Amsterdam (NL)
Boston Children's Hospital (US)
Harvard University (US)
Corresponding author: Nieuwdorp, Max
Kaplan, Lee M.
ORCID: Nieuwdorp, Max
Pai, Nikhil
Kaplan, Lee M.
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2014-05
Volume: 146
Issue: 6
Pages: 1525-1533
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/j.gastro.2014.02.008
OpenAlex: W1980143346
Cited by: 421
References: 76
Citations by year: 2026: 14 · 2025: 23 · 2024: 32 · 2023: 34 · 2022: 43 · 2021: 56 · 2020: 30 · 2019: 39 · 2018: 35 · 2017: 30 · 2016: 36 · 2015: 32 · 2014: 17
FWCI: 3.61
Type: journal article
Language: en
Open access: green
zenodo.org
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK-088661, RC2DK088661, P30DK040561)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: gut microbiota, energy balance, host metabolism, obesity, metabolic disorders, glucose metabolism, lipid metabolism, bile acids, mucus layer, mucosal immune response, microbial metabolites, therapeutic target
MeSH terms: Animals, Bacteria, Bile Acids and Salts, Diabetes Mellitus, Energy Metabolism, Gastrointestinal Diseases, Homeostasis, Humans, Intestinal Mucosa, Intestines, Obesity, Probiotics, Host-Pathogen Interactions, Microbiota

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Role of the Microbiome in Energy Regulation and Metabolism

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks