The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Role of the Microbiome in Energy Regulation and Metabolism
Open accessAbstract
Intestinal microbes regulate metabolic function and energy balance; an altered microbial ecology is believed to contribute to the development of several metabolic diseases. Relative species abundance and metabolic characteristics of the intestinal microbiota change substantially in those who are obese or have other metabolic disorders and in response to ingested nutrients or therapeutic agents. The mechanisms through which the intestinal microbiota and its metabolites affect host homeostasis are just beginning to be understood. We review the relationships between the intestinal microbiota and host metabolism, including energy intake, use, and expenditure, in relation to glucose and lipid metabolism. These associations, along with interactions among the intestinal microbiota, mucus layer, bile acids, and mucosal immune responses, reveal potential mechanisms by which the microbiota affect metabolism. We discuss how controlled studies involving direct perturbations of microbial communities in human and animal models are required to identify effective therapeutic targets in the microbiota.
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“It has been demonstrated that microbiota imbalances can induce systemic metabolic alterations”
From Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes (2019) · cites this paper as Nieuwdorp et al., 2014
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1 retracted
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Metadata
- Authors
- Nieuwdorp, M., Gilijamse, P. W., Pai, N., & Kaplan, L. M.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Boston Children's Hospital (US)
- Harvard University (US)
- Corresponding author
- Nieuwdorp, Max
- Kaplan, Lee M.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 146
- Issue
- 6
- Pages
- 1525-1533
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W1980143346
- Cited by
- 421
- References
- 76
- Citations by year
- 2026: 14 · 2025: 23 · 2024: 32 · 2023: 34 · 2022: 43 · 2021: 56 · 2020: 30 · 2019: 39 · 2018: 35 · 2017: 30 · 2016: 36 · 2015: 32 · 2014: 17
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- green
- zenodo.org
- Licence
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-088661, RC2DK088661, P30DK040561)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, energy balance, host metabolism, obesity, metabolic disorders, glucose metabolism, lipid metabolism, bile acids, mucus layer, mucosal immune response, microbial metabolites, therapeutic target
- MeSH terms
- Animals, Bacteria, Bile Acids and Salts, Diabetes Mellitus, Energy Metabolism, Gastrointestinal Diseases, Homeostasis, Humans, Intestinal Mucosa, Intestines, Obesity, Probiotics, Host-Pathogen Interactions, Microbiota
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