The DOI matches its Crossref record; 24 of the 25 references it cites were found in a registry or an index.
A Combination of Molecular Markers and Clinical Features Improve the Classification of Pancreatic Cysts
Open accessAbstract
Background & aims The management of pancreatic cysts poses challenges to both patients and their physicians. We investigated whether a combination of molecular markers and clinical information could improve the classification of pancreatic cysts and management of patients.Methods We performed a multi-center, retrospective study of 130 patients with resected pancreatic cystic neoplasms (12 serous cystadenomas, 10 solid pseudopapillary neoplasms, 12 mucinous cystic neoplasms, and 96 intraductal papillary mucinous neoplasms). Cyst fluid was analyzed to identify subtle mutations in genes known to be mutated in pancreatic cysts (BRAF, CDKN2A, CTNNB1, GNAS, KRAS, NRAS, PIK3CA, RNF43, SMAD4, TP53, and VHL); to identify loss of heterozygozity at CDKN2A, RNF43, SMAD4, TP53, and VHL tumor suppressor loci; and to identify aneuploidy. The analyses were performed using specialized technologies for implementing and interpreting massively parallel sequencing data acquisition. An algorithm was used to select markers that could classify cyst type and grade. The accuracy of the molecular markers was compared with that of clinical markers and a combination of molecular and clinical markers.Results We identified molecular markers and clinical features that classified cyst type with 90%-100% sensitivity and 92%-98% specificity. The molecular marker panel correctly identified 67 of the 74 patients who did not require surgery and could, therefore, reduce the number of unnecessary operations by 91%.Conclusions We identified a panel of molecular markers and clinical features that show promise for the accurate classification of cystic neoplasms of the pancreas and identification of cysts that require surgery.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In the context of mucinous pancreatic cysts, cyst fluid has been demonstrated to be an attractive substrate for demonstrating aberrant somatic mutations, microRNAs or proteins, which are then correlated with either the presence of mucinous epithelium per se or the progression to high-grade dysplasia and cancer.60,61”
From Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review (2021) · cites this paper as [61]
Experimental — accuracy not yet measuredIn the citing paper
“Moreover, the use of high-risk groups as controls and combining molecular markers with clinical features is an important consideration when identifying biomarkers capable of selecting populations at highest risk of development of pancreatic ductal adenocarcinoma for screening.75”
From Early detection of pancreatic cancer (2020) · cites this paper as [75]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Base-Calling of Automated Sequencer Traces Using Phred. I. Accuracy AssessmentPreprint
Ewing, B., Hillier, L., Wendl, M. C., & Green, P. (1998) · Genome Research · doi:10.1101/gr.8.3.175 · Cited by 6,993
Base-Calling of Automated Sequencer Traces Using Phred. II. Error Probabilities
Ewing, B., & Green, P. (1998) · Genome Research · doi:10.1101/gr.8.3.186 · Cited by 5,439
WHO Classification of Tumours of the Digestive System
Bosman, F. T. (2010) · Medical Entomology and Zoology · Cited by 5,041
International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas
Tanaka, M., Fernández-del Castillo, C., Adsay, V., Chari, S., Falconi, M., Jang, J.-Y., Kimura, W., Levy, P., Pitman, M. B., Schmidt, C. M., et al. (2012) · Pancreatology · doi:10.1016/j.pan.2012.04.004 · Cited by 2,354
Self-citationDetection and quantification of rare mutations with massively parallel sequencing
Kinde, I., Wu, J., Papadopoulos, N., Kinzler, K. W., & Vogelstein, B. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105422108 · Cited by 1,144
Self-citationIntraductal Papillary Mucinous Neoplasms of the Pancreas: An Updated Experience
Sohn, T., Yeo, C., Cameron, J., Hruban, R., Fukushima, N., Campbell, K., & Lillemoe, K. (2004) · Annals of Surgery · doi:10.1097/01.sla.0000128306.90650.aa · Cited by 915
Self-citationPrevalence of Unsuspected Pancreatic Cysts on MDCT
Laffan, T. A., Horton, K. M., Klein, A. P., Berlanstein, B. P., Siegelman, S. S., Kawamoto, S., Johnson, P. T., Fishman, E. K., & Hruban, R. H. (2008) · American Journal of Roentgenology · doi:10.2214/ajr.07.3340 · Cited by 882
Self-citationRecurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development
Wu, J., Matthaei, H., Maitra, A., Molin, M. D., Wood, L., Eshleman, J., Goggins, M., Canto, M., Schulick, R., Edil, B., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002543 · Cited by 786
Self-citationWu, J., Jiao, Y., Molin, M. D., Maitra, A., de Wilde, R. F., Wood, L. D., Eshleman, J. R., Goggins, M., Wolfgang, C. L., Canto, M. I., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118046108 · Cited by 652
Self-citationPrevalence of incidental pancreatic cysts in the adult population on MR imaging
Lee, K. S., Sekhar, A., Rofsky, N. M., & Pedrosa, I. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.122 · Cited by 610
Valsangkar, N. P., Morales-Oyarvide, V., Thayer, S. P., Ferrone, C. R., Wargo, J. A., Warshaw, A. L., & Fernández-del Castillo, C. (2012) · Surgery · doi:10.1016/j.surg.2012.05.033 · Cited by 418
A Systematic Review of Solid-Pseudopapillary Neoplasms
Law, J. K., Ahmed, A., Singh, V. K., Akshintala, V. S., Olson, M. T., Raman, S. P., Ali, S. Z., Fishman, E. K., Kamel, I. R., Canto, M. I., et al. (2014) · Pancreas · doi:10.1097/mpa.0000000000000061 · Cited by 380
Self-citationEvaluation of DNA from the Papanicolaou test to detect ovarian and endometrial cancers.
Kinde, I., Bettegowda, C., Wang, Y., Wu, J., Agrawal, N., Shih, I.-M., Kurman, R., Dao, F., Levine, D. A., Giuntoli, R., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3004952 · Cited by 327
Self-citationClinicopathological Features and Prognosis of Mucinous Cystic Neoplasm With Ovarian-Type Stroma
Yamao, K., Yanagisawa, A., Takahashi, K., Kimura, W., Doi, R., Fukushima, N., Ohike, N., Shimizu, M., Hatori, T., Nobukawa, B., et al. (2010) · Pancreas · doi:10.1097/mpa.0b013e3181f749d3 · Cited by 291
Self-citationSahora, K., Mino-Kenudson, M., Brugge, W., Thayer, S. P., Ferrone, C. R., Sahani, D., Pitman, M. B., Warshaw, A. L., Lillemoe, K. D., & Fernandez-del Castillo, C. F. (2013) · Annals of Surgery · doi:10.1097/sla.0b013e3182a18f48 · Cited by 285
Self-citationLennon, A. M., Wolfgang, C. L., Canto, M. I., Klein, A. P., Herman, J. M., Goggins, M., Fishman, E. K., Kamel, I. R., Weiss, M. J., Diaz, L. A., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0734 · Cited by 268
Self-citationKanda, M., Sadakari, Y., Borges, M., Topazian, M., Farrell, J., Syngal, S., Lee, J., Kamel, I., Lennon, A. M., Knight, S., et al. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.11.016 · Cited by 181
Self-citationSerial Assessment of Human Tumor Burdens in Mice by the Analysis of Circulating DNA
Rago, C., Huso, D. L., Diehl, F., Karim, B. O., Liu, G., Papadopoulos, N., Samuels, Y., Velculescu, V. E., Vogelstein, B., Kinzler, K. W., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0605 · Cited by 165
Self-citationMasica, D. L., & Karchin, R. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-0180 · Cited by 162
Self-citationKinde, I., Papadopoulos, N., Kinzler, K. W., & Vogelstein, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041162 · Cited by 69
Self-citationLennon, A. M., Manos, L. L., Hruban, R. H., Ali, S. Z., Fishman, E. K., Kamel, I. R., Raman, S. P., Zaheer, A., Hutfless, S. M., Salamone, A., et al. (2014) · Annals of Surgical Oncology · doi:10.1245/s10434-014-3739-x · Cited by 57
Self-citationCystic Neoplasms of the Pancreas
Lennon, A. M., & Wolfgang, C. L. (2013) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-012-2072-6 · Cited by 51
Self-citationCollections of Simultaneously Altered Genes as Biomarkers of Cancer Cell Drug Response
Masica, D. L., & Karchin, R. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3122 · Cited by 50
Self-citationBocsi, J., Berczi, C., Balázs, G., & Lapis, K. (1998) · PubMed · Cited by 3
Cited by
Sorted by citations
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas
Tanaka, M., Fernández-del Castillo, C., Kamisawa, T., Jang, J. Y., Levy, P., Ohtsuka, T., Salvia, R., Shimizu, Y., Tada, M., & Wolfgang, C. L. (2017) · Pancreatology · doi:10.1016/j.pan.2017.07.007 · Cited by 1,797
Self-citationEuropean evidence-based guidelines on pancreatic cystic neoplasms
The European Study Group on Cystic Tumours of the Pancreas (2018) · Gut · doi:10.1136/gutjnl-2018-316027 · Cited by 1,417
Molecular subtypes of pancreatic cancer
Collisson, E. A., Bailey, P., Chang, D. K., & Biankin, A. V. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0109-y · Cited by 892
Early Detection of Pancreatic Cancer: Opportunities and Challenges
Singhi, A. D., Koay, E. J., Chari, S. T., & Maitra, A. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.01.259 · Cited by 841
Self-citationACG Clinical Guideline: Diagnosis and Management of Pancreatic Cysts
Elta, G. H., Enestvedt, B. K., Sauer, B. G., & Lennon, A. M. (2018) · The American Journal of Gastroenterology · doi:10.1038/ajg.2018.14 · Cited by 734
Self-citation
Metadata
- Authors
- Springer, S., Wang, Y., Dal Molin, M., Masica, D. L., Jiao, Y., Kinde, I., Blackford, A., Raman, S. P., Wolfgang, C. L., Tomita, T., Niknafs, N., Douville, C., Ptak, J., Dobbyn, L., Allen, P. J., Klimstra, D. S., Schattner, M. A., Schmidt, C. M., Yip-Schneider, M., Cummings, O. W., Brand, R. E., Zeh, H. J., Singhi, A. D., Scarpa, A., Salvia, R., Malleo, G., Zamboni, G., Falconi, M., Jang, J.-Y., Kim, S.-W., Kwon, W., Hong, S.-M., Song, K.-B., Kim, S. C., Swan, N., Murphy, J., Geoghegan, J., Brugge, W., Fernandez-Del Castillo, C., Mino-Kenudson, M., Schulick, R., Edil, B. H., Adsay, V., Paulino, J., van Hooft, J., Yachida, S., Nara, S., Hiraoka, N., Yamao, K., Hijioka, S., van der Merwe, S., Goggins, M., Canto, M. I., Ahuja, N., Hirose, K., Makary, M., Weiss, M. J., Cameron, J., Pittman, M., Eshleman, J. R., Diaz, L. A., Papadopoulos, N., Kinzler, K. W., Karchin, R., Hruban, R. H., Vogelstein, B., & Lennon, A. M.
- Affiliations
- Howard Hughes Medical Institute (US)
- Johns Hopkins University (US)
- Memorial Sloan Kettering Cancer Center (US)
- Indiana University Bloomington (US)
- University of Pittsburgh (US)
- University of Verona (IT)
- IRCCS Ospedale San Raffaele (IT)
- Seoul National University (KR)
- Asan Medical Center (KR)
- St. Vincent's University Hospital (IE)
- Massachusetts General Hospital (US)
- University of Colorado Boulder (US)
- Emory University (US)
- Hospital Curry Cabral (PT)
- National Cancer Centre Japan (JP)
- Aichi Cancer Center (JP)
- Corresponding author
- Lennon, Anne Marie
- ORCID
- Springer, Simeon
- Wang, Yuxuan
- Jiao, Yuchen
- Blackford, Amanda
- Wolfgang, Christopher L.
- Tomita, Tyler
- Niknafs, Noushin
- Douville, Christopher
- Ptak, Janine
- Dobbyn, Lisa
- Klimstra, David S.
- Schattner, Mark A.
- Schmidt, C. Max
- Yip-Schneider, Michele
- Cummings, Oscar W.
- Brand, Randall E.
- Zeh, Herbert J.
- Singhi, Aatur D.
- Scarpa, Aldo
- Salvia, Roberto
- Malleo, Giuseppe
- Zamboni, Giuseppe
- Falconi, Massimo
- Jang, Jin-Young
- Kim, Sun-Whe
- Kwon, Wooil
- Hong, Seung-Mo
- Song, Ki-Byung
- Kim, Song Cheol
- Swan, Niall
- Geoghegan, Justin
- Brugge, William
- Mino-Kenudson, Mari
- Schulick, Richard
- Edil, Barish H.
- Adsay, Volkan
- Paulino, Jorge
- Yachida, Shinichi
- Nara, Satoshi
- Hiraoka, Nobuyoshi
- Yamao, Kenji
- Goggins, Michael
- Canto, Marcia Irene
- Ahuja, Nita
- Hirose, Kenzo
- Makary, Martin
- Weiss, Matthew J.
- Pittman, Meredith
- Eshleman, James R.
- Diaz, Luis A.
- Papadopoulos, Nickolas
- Kinzler, Kenneth W.
- Karchin, Rachel
- Hruban, Ralph H.
- Vogelstein, Bert
- Lennon, Anne Marie
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 149
- Issue
- 6
- Pages
- 1501-1510
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC4782782
- OpenAlex
- W1945428417
- Cited by
- 477
- References
- 25
- Citations by year
- 2026: 31 · 2025: 33 · 2024: 31 · 2023: 35 · 2022: 35 · 2021: 49 · 2020: 47 · 2019: 55 · 2018: 55 · 2017: 64 · 2016: 40 · 2015: 2
- FWCI
- 23.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- PubMed Central (acceptedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion, cc-by-nc-nd)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Lirias (KU Leuven) (submittedVersion)
- Funders
- Lustgarten Foundation
- Virginia and D.K. Ludwig Fund for Cancer Research
- National Cancer Institute (P50CA-62924, R37CA043460, P50CA062924, P30CA008748, P30CA006973)
- National Institute of General Medical Sciences (T32GM007309, T32GM007057, T32GM007814)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Keywords
- pancreatic cysts, pancreatic cystic neoplasms, molecular markers, cyst classification, intraductal papillary mucinous neoplasm, serous cystadenoma, solid pseudopapillary neoplasm, mucinous cystic neoplasm, cyst fluid analysis, loss of heterozygosity, aneuploidy, tumor suppressor, BRAF, CDKN2A, CTNNB1, TP53, VHL, RNF43, SMAD4, unnecessary surgery, clinical decision-making
- MeSH terms
- Adult, Algorithms, Female, Genetic Testing, Humans, Male, Middle Aged, Mutation, Pancreas, Pancreatic Cyst, Phenotype, Predictive Value of Tests, Prognosis, Retrospective Studies, Biomarkers, Tumor, Genetic Predisposition to Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
