The DOI matches its Crossref record; 76 of the 78 references it cites were found in a registry or an index.
Liver Stem Cells: Experimental Findings and Implications for Human Liver Disease
Open accessAbstract
Evidence from human histopathology and experimental studies with rodents and zebrafish has shown that hepatocytes and cholangiocytes may function as facultative stem cells for each other in conditions of impaired regeneration. The interpretation of the findings derived from these studies has generated considerable discussion and some controversies. This review examines the evidence obtained from the different experimental models and considers implications that these studies may have for human liver disease.
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“Notably, in chronic liver diseases, HHs with expression of progenitor-associated markers were also documented in regenerative nodules (Michalopoulos and Khan, 2015; Yoon et al., 2011”
From In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity (2018) · cites this paper as Michalopoulos and Khan, 2015
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“Cell plasticity has lately been recognized to play an important role in liver regeneration (Kopp et al., 2016; Li et al., 2016; Michalopoulos and Khan, 2015”
From In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity (2018) · cites this paper as Michalopoulos and Khan, 2015
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Cites
Michalopoulos, G. K., & DeFrances, M. C. (1997) · Science · doi:10.1126/science.276.5309.60 · Cited by 2,828
Self-citationLong-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver
Huch, M., Gehart, H., van Boxtel, R., Hamer, K., Blokzijl, F., Verstegen, M. M. A., Ellis, E., van Wenum, M., Fuchs, S. A., de Ligt, J., et al. (2015) · Cell · doi:10.1016/j.cell.2014.11.050 · Cited by 1,619
Mederacke, I., Hsu, C. C., Troeger, J. S., Huebener, P., Mu, X., Dapito, D. H., Pradere, J.-P., & Schwabe, R. F. (2013) · Nature Communications · doi:10.1038/ncomms3823 · Cited by 1,443
Michalopoulos, G. K. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21172 · Cited by 1,384
Self-citationHippo Pathway Activity Influences Liver Cell Fate
Yimlamai, D., Christodoulou, C., Galli, G. G., Yanger, K., Pepe-Mooney, B., Gurung, B., Shrestha, K., Cahan, P., Stanger, B. Z., & Camargo, F. D. (2014) · Cell · doi:10.1016/j.cell.2014.03.060 · Cited by 857
Furuyama, K., Kawaguchi, Y., Akiyama, H., Horiguchi, M., Kodama, S., Kuhara, T., Hosokawa, S., Elbahrawy, A., Soeda, T., Koizumi, M., et al. (2010) · Nature Genetics · doi:10.1038/ng.722 · Cited by 841
Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver
Wang, B., Zhao, L., Fish, M., Logan, C. Y., & Nusse, R. (2015) · Nature · doi:10.1038/nature14863 · Cited by 674
Bipotential Adult Liver Progenitors Are Derived from Chronically Injured Mature Hepatocytes
Tarlow, B. D., Pelz, C., Naugler, W. E., Wakefield, L., Wilson, E. M., Finegold, M. J., & Grompe, M. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.09.008 · Cited by 533
Cholangiocarcinomas can originate from hepatocytes in mice
Fan, B., Malato, Y., Calvisi, D. F., Naqvi, S., Razumilava, N., Ribback, S., Gores, G. J., Dombrowski, F., Evert, M., Chen, X., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63212 · Cited by 529
Robust cellular reprogramming occurs spontaneously during liver regeneration
Yanger, K., Zong, Y., Maggs, L. R., Shapira, S. N., Maddipati, R., Aiello, N. M., Thung, S. N., Wells, R. G., Greenbaum, L. E., & Stanger, B. Z. (2013) · Genes & Development · doi:10.1101/gad.207803.112 · Cited by 484
Cited by
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Items 101–109 of 109
Hepatite C crônica na fase cirrótica, efeito dos DAAs na histopatologia dos explantes
Pasinato, A. P. B. F. (2023) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2023.tde-01082023-125434
Abdellatif, H., Jabri, R. A., Albalushi, H. M. A., & Mushaiqri, M. A. (2025) · Anatomy & Cell Biology · doi:10.5115/acb.24.231
Huang, W.-J., Qiu, B.-J., Qi, X.-S., Chen, C.-Y., Liu, W.-M., Zhou, S.-A., Ding, M., Lu, F.-F., Zhao, J., Tang, D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24234232
Mechanisms of Liver Regeneration
Kofler, A., Poelsler, L. H., Oberhuber, R., & Primavesi, F. (2026) · Springer eBooks · doi:10.1007/978-3-032-10997-2_1
Wang, L., Tang, Z., & Xu, H. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40423-8.00003-8
Bousaleh, M. (2019) · theses.fr (ABES) · doi:10.70675/d39b3d1bzaa47z40c1zbde5z90e63b846fc9
Transient culture of adult human hepatocytes as organoids improves engineered liver engraftment
Saxton, S. H., Kang, I., Mitchell, S., Lotto, J., Upadhyay, A., Zou, C.-H., Quirk, C., McCray, T. N., Prado, O., Johansson, F., et al. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124465
TGF-β serves as a critical signaling determinant of liver progenitor cell activation and function
Tong, C., Lin, T., Wang, H., Jiang, L., Yuan, X., Luo, W., Zhou, M., Torre, C. D. L., Liu, H., Shao, C., et al. (2026) · Journal of Clinical Investigation · doi:10.1172/jci199913
Paine‐Cabrera, D., Sánchez-Guerrero, G., Robarts, D. R., Kotulkar, M., & Apte, U. M. (2026) · Biology · doi:10.3390/biology15211908
Metadata
- Authors
- Michalopoulos, G. K., & Khan, Z.
- Affiliations
- University of Pittsburgh (US)
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 149
- Issue
- 4
- Pages
- 876-882
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC4584191
- OpenAlex
- W2112926558
- Cited by
- 109
- References
- 78
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 6 · 2023: 13 · 2022: 10 · 2021: 11 · 2020: 11 · 2019: 10 · 2018: 18 · 2017: 8 · 2016: 10 · 2015: 3
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (2r01ca103958-06a1)
- National Cancer Institute (R01CA035373, R01-CA103958)
- National Institute of Diabetes and Digestive and Kidney Diseases (P01DK096990)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD071834, K12HD052892)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- liver stem cells, cholangiocytes, hepatocytes, liver regeneration, liver disease, zebrafish model, rodent models
- MeSH terms
- Animals, Bile Ducts, Intrahepatic, Cell Differentiation, Gene Expression Regulation, Humans, Liver, Liver Diseases, Liver Regeneration, Stem Cells, Signal Transduction, Cell Lineage, Hepatocytes, Cell Proliferation
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