Cited by 109Liver physiology and pathologyMesenchymal stem cell researchTissue Engineering and Regenerative Medicine

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Liver Stem Cells: Experimental Findings and Implications for Human Liver Disease

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Michalopoulos, George K., Khan, Zahida·2015·Gastroenterology

DOI 10.1053/j.gastro.2015.08.004PMC PMC4584191

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Abstract

Evidence from human histopathology and experimental studies with rodents and zebrafish has shown that hepatocytes and cholangiocytes may function as facultative stem cells for each other in conditions of impaired regeneration. The interpretation of the findings derived from these studies has generated considerable discussion and some controversies. This review examines the evidence obtained from the different experimental models and considers implications that these studies may have for human liver disease.

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Authors: Michalopoulos, G. K., & Khan, Z.
Affiliations: University of Pittsburgh (US)
ORCID: Michalopoulos, George K.
Khan, Zahida
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2015-10
Volume: 149
Issue: 4
Pages: 876-882
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/j.gastro.2015.08.004
PMC: PMC4584191
OpenAlex: W2112926558
Cited by: 109
References: 78
Citations by year: 2026: 5 · 2025: 4 · 2024: 6 · 2023: 13 · 2022: 10 · 2021: 11 · 2020: 11 · 2019: 10 · 2018: 18 · 2017: 8 · 2016: 10 · 2015: 3
FWCI: 1.86
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (2r01ca103958-06a1)
National Cancer Institute (R01CA035373, R01-CA103958)
National Institute of Diabetes and Digestive and Kidney Diseases (P01DK096990)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD071834, K12HD052892)
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords: liver stem cells, cholangiocytes, hepatocytes, liver regeneration, liver disease, zebrafish model, rodent models
MeSH terms: Animals, Bile Ducts, Intrahepatic, Cell Differentiation, Gene Expression Regulation, Humans, Liver, Liver Diseases, Liver Regeneration, Stem Cells, Signal Transduction, Cell Lineage, Hepatocytes, Cell Proliferation

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Liver Stem Cells: Experimental Findings and Implications for Human Liver Disease

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