The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Circadian Clock Control of Liver Metabolic Functions
Open accessAbstract
The circadian clock is an endogenous biological timekeeping system that synchronizes physiology and behavior to day/night cycles. A wide variety of processes throughout the entire gastrointestinal tract and notably the liver appear to be under circadian control. These include various metabolic functions such as nutrient uptake, processing, and detoxification, which align organ function to cycle with nutrient supply and demand. Remarkably, genetic or environmental disruption of the circadian clock can cause metabolic diseases or exacerbate pathological states. In addition, modern lifestyles force more and more people worldwide into asynchrony between the external time and their circadian clock, resulting in a constant state of social jetlag. Recent evidence indicates that interactions between altered energy metabolism and disruptions in the circadian clock create a downward spiral that can lead to diabetes and other metabolic diseases. In this review, we provide an overview of rhythmic processes in the liver and highlight the functions of circadian clock genes under physiological and pathological conditions; we focus on their roles in regulation of hepatic glucose as well as lipid and bile acid metabolism and detoxification and their potential effects on the development of fatty liver and nonalcoholic steatohepatitis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Metabolic homeostasis is linked to the circadian clock with the clock involved in regulation of hepatic triglyceride accumulation, inflammation, oxidative stress and mitochondrial dysfunction 29, all of which may contribute to the pathogenesis of NAFLD.”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [29]
In the citing paper
“Circadian disruption may play a role in the pathogenesis of nonalcoholic fatty liver disease”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [29]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485
Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.183500 · Cited by 2,394
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,310
A circadian gene expression atlas in mammals: Implications for biology and medicine
Zhang, R., Lahens, N. F., Ballance, H. I., Hughes, M. E., & Hogenesch, J. B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408886111 · Cited by 2,304
Hatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E. A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J. A. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.019 · Cited by 1,986
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes
Marcheva, B., Ramsey, K. M., Buhr, E. D., Kobayashi, Y., Su, H., Ko, C. H., Ivanova, G., Omura, C., Mo, S., Vitaterna, M. H., et al. (2010) · Nature · doi:10.1038/nature09253 · Cited by 1,525
Extensive and divergent circadian gene expression in liver and heart
Storch, K.-F., Lipan, O., Leykin, I., Viswanathan, N., Davis, F. C., Wong, W. H., & Weitz, C. J. (2002) · Nature · doi:10.1038/nature744 · Cited by 1,509
Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors
Lu, T. T., Makishima, M., Repa, J. J., Schoonjans, K., Kerr, T. A., Auwerx, J., & Mangelsdorf, D. J. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00050-2 · Cited by 1,487
Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis
Thaiss, C. A., Zeevi, D., Levy, M., Zilberman-Schapira, G., Suez, J., Tengeler, A. C., Abramson, L., Katz, M. N., Korem, T., Zmora, N., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.048 · Cited by 1,449
Nakahata, Y., Kaluzova, M., Grimaldi, B., Sahar, S., Hirayama, J., Chen, D., Guarente, L. P., & Sassone-Corsi, P. (2008) · Cell · doi:10.1016/j.cell.2008.07.002 · Cited by 1,427
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–104 of 104
Li, Y., Lu, L., & Androulakis, I. P. (2024) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2023.08.005 · Cited by 17
3D bioprinting lobule-like hepatorganoids with induced vascularization for orthotopic implantation
Yan, J., Ye, Z., Lu, Y., Yuan, Y., Wang, X., Yan, T., Yin, J., & Wang, Y. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101515 · Cited by 15
Single MHC‐I Expression Promotes Virus‐Induced Liver Immunopathology
Xu, H. C., Huang, J., Pandyra, A. A., Pandey, P., Wang, R., Zhang, Z., Zhuang, Y., Gertzen, C. G. W., Münk, C., Herebian, D., et al. (2022) · Hepatology Communications · doi:10.1002/hep4.1913 · Cited by 9
Yang, S., Hao, J., Ooka, M., & Xia, M. (2026) · Scientific Reports · doi:10.1038/s41598-025-32539-0 · Cited by 5
Metadata
- Authors
- Reinke, H., & Asher, G.
- Affiliations
- Leibniz Institute of Environmental Medicine (DE)
- Weizmann Institute of Science (IL)
- Corresponding author
- Reinke, Hans
- Asher, Gad
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 150
- Issue
- 3
- Pages
- 574-580
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2186849858
- Cited by
- 321
- References
- 76
- Citations by year
- 2026: 32 · 2025: 38 · 2024: 45 · 2023: 32 · 2022: 39 · 2021: 31 · 2020: 35 · 2019: 26 · 2018: 22 · 2017: 15 · 2016: 6
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Research Council (ERC-2011 METACYCLES 310320, RE 3046/2-1, G-1199-230.9/2012, HFSP CDA00014/2012, ISF 138/12)
- Deutsche Forschungsgemeinschaft (ERC-2011 METACYCLES 310320, RE 3046/2-1, G-1199-230.9/2012, HFSP CDA00014/2012, ISF 138/12)
- German-Israeli Foundation for Scientific Research and Development (ERC-2011 METACYCLES 310320, RE 3046/2-1, G-1199-230.9/2012, HFSP CDA00014/2012, ISF 138/12)
- Israel Science Foundation (ERC-2011 METACYCLES 310320, RE 3046/2-1, G-1199-230.9/2012, HFSP CDA00014/2012, ISF 138/12)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- circadian clock, hepatic metabolism, clock genes, hepatic glucose metabolism, lipid metabolism, bile acid metabolism, detoxification, hepatic steatosis, nonalcoholic steatohepatitis, social jetlag, metabolic disorders, diabetes mellitus
- MeSH terms
- Animals, Circadian Rhythm, Energy Metabolism, Homeostasis, Humans, Liver, Inactivation, Metabolic, Time Factors, Signal Transduction, Circadian Rhythm Signaling Peptides and Proteins, Non-alcoholic Fatty Liver Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
