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Circadian Clock Control of Liver Metabolic Functions
Open accessAbstract
The circadian clock is an endogenous biological timekeeping system that synchronizes physiology and behavior to day/night cycles. A wide variety of processes throughout the entire gastrointestinal tract and notably the liver appear to be under circadian control. These include various metabolic functions such as nutrient uptake, processing, and detoxification, which align organ function to cycle with nutrient supply and demand. Remarkably, genetic or environmental disruption of the circadian clock can cause metabolic diseases or exacerbate pathological states. In addition, modern lifestyles force more and more people worldwide into asynchrony between the external time and their circadian clock, resulting in a constant state of social jetlag. Recent evidence indicates that interactions between altered energy metabolism and disruptions in the circadian clock create a downward spiral that can lead to diabetes and other metabolic diseases. In this review, we provide an overview of rhythmic processes in the liver and highlight the functions of circadian clock genes under physiological and pathological conditions; we focus on their roles in regulation of hepatic glucose as well as lipid and bile acid metabolism and detoxification and their potential effects on the development of fatty liver and nonalcoholic steatohepatitis.
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“Metabolic homeostasis is linked to the circadian clock with the clock involved in regulation of hepatic triglyceride accumulation, inflammation, oxidative stress and mitochondrial dysfunction 29, all of which may contribute to the pathogenesis of NAFLD.”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [29]
In the citing paper
“Circadian disruption may play a role in the pathogenesis of nonalcoholic fatty liver disease”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [29]
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Metadata
- Authors
- Reinke, H., & Asher, G.
- Affiliations
- Leibniz Institute of Environmental Medicine (DE)
- Weizmann Institute of Science (IL)
- Corresponding author
- Reinke, Hans
- Asher, Gad
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 150
- Issue
- 3
- Pages
- 574-580
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2186849858
- Cited by
- 321
- References
- 76
- Citations by year
- 2026: 32 · 2025: 38 · 2024: 45 · 2023: 32 · 2022: 39 · 2021: 31 · 2020: 35 · 2019: 26 · 2018: 22 · 2017: 15 · 2016: 6
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Research Council (ERC-2011 METACYCLES 310320, RE 3046/2-1, G-1199-230.9/2012, HFSP CDA00014/2012, ISF 138/12)
- Deutsche Forschungsgemeinschaft (ERC-2011 METACYCLES 310320, RE 3046/2-1, G-1199-230.9/2012, HFSP CDA00014/2012, ISF 138/12)
- German-Israeli Foundation for Scientific Research and Development (ERC-2011 METACYCLES 310320, RE 3046/2-1, G-1199-230.9/2012, HFSP CDA00014/2012, ISF 138/12)
- Israel Science Foundation (ERC-2011 METACYCLES 310320, RE 3046/2-1, G-1199-230.9/2012, HFSP CDA00014/2012, ISF 138/12)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- circadian clock, hepatic metabolism, clock genes, hepatic glucose metabolism, lipid metabolism, bile acid metabolism, detoxification, hepatic steatosis, nonalcoholic steatohepatitis, social jetlag, metabolic disorders, diabetes mellitus
- MeSH terms
- Animals, Circadian Rhythm, Energy Metabolism, Homeostasis, Humans, Liver, Inactivation, Metabolic, Time Factors, Signal Transduction, Circadian Rhythm Signaling Peptides and Proteins, Non-alcoholic Fatty Liver Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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