Cited by 321Circadian rhythm and melatoninDietary Effects on HealthLiver physiology and pathology

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Circadian Clock Control of Liver Metabolic Functions

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Reinke, Hans, Asher, Gad·2016·Gastroenterology

DOI 10.1053/j.gastro.2015.11.043

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Abstract

The circadian clock is an endogenous biological timekeeping system that synchronizes physiology and behavior to day/night cycles. A wide variety of processes throughout the entire gastrointestinal tract and notably the liver appear to be under circadian control. These include various metabolic functions such as nutrient uptake, processing, and detoxification, which align organ function to cycle with nutrient supply and demand. Remarkably, genetic or environmental disruption of the circadian clock can cause metabolic diseases or exacerbate pathological states. In addition, modern lifestyles force more and more people worldwide into asynchrony between the external time and their circadian clock, resulting in a constant state of social jetlag. Recent evidence indicates that interactions between altered energy metabolism and disruptions in the circadian clock create a downward spiral that can lead to diabetes and other metabolic diseases. In this review, we provide an overview of rhythmic processes in the liver and highlight the functions of circadian clock genes under physiological and pathological conditions; we focus on their roles in regulation of hepatic glucose as well as lipid and bile acid metabolism and detoxification and their potential effects on the development of fatty liver and nonalcoholic steatohepatitis.

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Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.183500 · Cited by 2,394
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Marcheva, B., Ramsey, K. M., Buhr, E. D., Kobayashi, Y., Su, H., Ko, C. H., Ivanova, G., Omura, C., Mo, S., Vitaterna, M. H., et al. (2010) · Nature · doi:10.1038/nature09253 · Cited by 1,525
Extensive and divergent circadian gene expression in liver and heart
Storch, K.-F., Lipan, O., Leykin, I., Viswanathan, N., Davis, F. C., Wong, W. H., & Weitz, C. J. (2002) · Nature · doi:10.1038/nature744 · Cited by 1,509
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Authors: Reinke, H., & Asher, G.
Affiliations: Leibniz Institute of Environmental Medicine (DE)
Weizmann Institute of Science (IL)
Corresponding author: Reinke, Hans
Asher, Gad
ORCID: Reinke, Hans
Asher, Gad
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2016-03
Volume: 150
Issue: 3
Pages: 574-580
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/j.gastro.2015.11.043
OpenAlex: W2186849858
Cited by: 321
References: 76
Citations by year: 2026: 32 · 2025: 38 · 2024: 45 · 2023: 32 · 2022: 39 · 2021: 31 · 2020: 35 · 2019: 26 · 2018: 22 · 2017: 15 · 2016: 6
FWCI: 1.55
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Funders: European Research Council (ERC-2011 METACYCLES 310320, RE 3046/2-1, G-1199-230.9/2012, HFSP CDA00014/2012, ISF 138/12)
Deutsche Forschungsgemeinschaft (ERC-2011 METACYCLES 310320, RE 3046/2-1, G-1199-230.9/2012, HFSP CDA00014/2012, ISF 138/12)
German-Israeli Foundation for Scientific Research and Development (ERC-2011 METACYCLES 310320, RE 3046/2-1, G-1199-230.9/2012, HFSP CDA00014/2012, ISF 138/12)
Israel Science Foundation (ERC-2011 METACYCLES 310320, RE 3046/2-1, G-1199-230.9/2012, HFSP CDA00014/2012, ISF 138/12)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords: circadian clock, hepatic metabolism, clock genes, hepatic glucose metabolism, lipid metabolism, bile acid metabolism, detoxification, hepatic steatosis, nonalcoholic steatohepatitis, social jetlag, metabolic disorders, diabetes mellitus
MeSH terms: Animals, Circadian Rhythm, Energy Metabolism, Homeostasis, Humans, Liver, Inactivation, Metabolic, Time Factors, Signal Transduction, Circadian Rhythm Signaling Peptides and Proteins, Non-alcoholic Fatty Liver Disease

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Circadian Clock Control of Liver Metabolic Functions

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