Paneth cell defects induce microbiota dysbiosis in mice and promote visceral hypersensitivity
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Background & aims Separation of newborn rats from their mothers induces visceral hypersensitivity and impaired epithelial secretory cell lineages when they are adults. Little is known about the mechanisms by which maternal separation causes visceral hypersensitivity or its relationship with defects in epithelial secretory cell lineages.Methods We performed studies with C3H/HeN mice separated from their mothers as newborns and mice genetically engineered (Sox9 flox/flox-vil-cre on C57BL/6 background) to have deficiencies in Paneth cells. Paneth cell deficiency was assessed by lysozyme staining of ileum tissues and lysozyme activity in fecal samples. When mice were 50 days old, their abdominal response to colorectal distension was assessed by electromyography. Fecal samples were collected and microbiota were analyzed using Gut Low-Density Array quantitative polymerase chain reaction.Results Mice with maternal separation developed visceral hypersensitivity and defects in Paneth cells, as reported from rats, compared with mice without maternal separation. Sox9 flox/flox-vil-Cre mice also had increased visceral hypersensitivity compared with control littermate Sox9 flox/flox mice. Fecal samples from mice with maternal separation and from Sox9 flox/flox-vil-cre mice had evidence for intestinal dysbiosis of the microbiota, characterized by expansion of Escherichia coli. Daily gavage of conventional C3H/HeN adult mice with 10 9 commensal E coli induced visceral hypersensitivity. Conversely, daily oral administration of lysozyme prevented expansion of E coli during maternal separation and visceral hypersensitivity.Conclusions Mice with defects in Paneth cells (induced by maternal separation or genetically engineered) have intestinal expansion of E coli leading to visceral hypersensitivity. These findings provide evidence that Paneth cell function and intestinal dysbiosis are involved in visceral sensitivity.
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Riba et al. demonstrated a correlation between visceral hypersensitivity and increased E. coli abundance, followed by induction of hypersensitivity in response to E. coli gavage in mice.
“A recent study by Riba et al.67 demonstrated a correlation between visceral hypersensitivity and increase of Escherichia coli abundance followed by induction of hypersensitivity in response to E. coli gavage in mice.”
From The gut Microbiome in adult and pediatric functional gastrointestinal disorders (2019) · cites this paper as [67]
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Self-citation
- Authors
- Riba, A., Olier, M., Lacroix-Lamandé, S., Lencina, C., Bacquié, V., Harkat, C., Gillet, M., Baron, M., Sommer, C., Mallet, V., Salvador-Cartier, C., Laurent, F., Théodorou, V., & Ménard, S.
- Affiliations
- Université Toulouse III - Paul Sabatier (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Corresponding author
- Ménard, Sandrine
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 153
- Issue
- 6
- Pages
- 1594-1606.e2
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2752878443
- Cited by
- 78
- References
- 57
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 10 · 2023: 14 · 2022: 8 · 2021: 8 · 2020: 16 · 2019: 10 · 2018: 6 · 2017: 1
- FWCI
- 9.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Keywords
- Paneth cells, visceral hypersensitivity, gut dysbiosis, maternal separation, gut microbiota, Escherichia coli, SOX9, lysozyme, colorectal distension, gut-brain axis
- MeSH terms
- Gastrointestinal Microbiome, Age Factors, Animals, Animals, Newborn, Anxiety, Separation, Disease Models, Animal, Escherichia coli, Feces, Female, Hyperalgesia, Mice, Inbred C3H, Mice, Inbred C57BL, Muramidase, Phenotype, Mice, Knockout, Paneth Cells, Genetic Predisposition to Disease, SOX9 Transcription Factor, Visceral Pain, Dysbiosis
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