Mechanisms of Fibrosis Development in Nonalcoholic Steatohepatitis

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Decrease in UCP1 by sustained high lipid promotes NK cell necroptosis to exacerbate nonalcoholic liver fibrosis

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Insights Into the Pathophysiology of Liver Disease in HCV/HIV: Does it End With HCV Cure?

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A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver

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A mutation in LXRα uncovers a role for cholesterol sensing in limiting metabolic dysfunction-associated steatohepatitis

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RXRα modulates hepatic stellate cell activation and liver fibrosis by targeting CaMKKβ–AMPKα axis

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A higher FIB‐4 index is associated with an increased incidence of renal failure in the general population

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17α-estradiol, a lifespan-extending compound, attenuates liver fibrosis by modulating collagen turnover rates in male mice

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Screening for NAFLD—Current Knowledge and Challenges

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Can Nutraceuticals Support the Treatment of MASLD/MASH, and thus Affect the Process of Liver Fibrosis?

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Proresolving lipid mediators and liver disease

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Autophagy affects hepatic fibrosis progression by regulating macrophage polarization and exosome secretion

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Advances in the treatment of liver injury based on mesenchymal stem cell-derived exosomes

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Endothelial group IVA phospholipase A2 promotes hepatic fibrosis with sinusoidal capillarization in the early stage of non-alcoholic steatohepatitis in mice

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Liver Steatosis: A Marker of Metabolic Risk in Children

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Regulation of SIRT1-TLR2/TLR4 pathway in cell communication from macrophages to hepatic stellate cells contribute to alleviates hepatic fibrosis by Luteoloside

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Low-Dose Administration of Cannabigerol Attenuates Inflammation and Fibrosis Associated with Methionine/Choline Deficient Diet-Induced NASH Model via Modulation of Cannabinoid Receptor

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A Healthy Diet is Associated with a Lower Risk of Hepatic Fibrosis

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State of CD8+ T cells in progression from nonalcoholic steatohepatitis to hepatocellular carcinoma: From pathogenesis to immunotherapy

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Transcription factors, metabolic dysfunction-associated fatty liver disease, and therapeutic implications

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Aldehydes alter TGF-β signaling and induce obesity and cancer

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Grape pomace reduces the severity of non-alcoholic hepatic steatosis and the development of steatohepatitis by improving insulin sensitivity and reducing ectopic fat deposition in mice

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Procollagen C-Proteinase Enhancer-1 (PCPE-1) deficiency in mice reduces liver fibrosis but not NASH progression

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Sterile inflammation in MASH: emerging role of extracellular RNA and therapeutic strategies

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The T Cell Receptor Immune Repertoire Protects the Liver From Reconsitution

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Potential biomarkers in the fibrosis progression of nonalcoholic steatohepatitis (NASH)

Wang, Z., Zhao, Z., Xia, Y., Cai, Z., Wang, C., Shen, Y., Liu, R., Qin, H., Jia, J., & Yuan, G. (2022) · Journal of Endocrinological Investigation · doi:10.1007/s40618-022-01773-y · Cited by 18

Sirtuin 6 protects against hepatic fibrogenesis by suppressing the YAP and TAZ function

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Ganfule capsule alleviates bile duct ligation-induced liver fibrosis in mice by inhibiting glutamine metabolism

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Acinar ATP8b1/LPC pathway promotes macrophage efferocytosis and clearance of inflammation during chronic pancreatitis development

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Elevated serum phosphatidylcholine (16:1/22:6) levels promoted by fish oil and vitamin D 3 are highly correlated with biomarkers of non-alcoholic fatty liver disease in Chinese subjects

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Discussing the role of circular RNA in the pathogenesis of non-alcoholic fatty liver disease and its complications

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Hydrogel microneedle patch for treatment of liver fibrosis

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Enhanced cytokine signaling and ferroptosis defense interplay initiates obesity-associated pancreatic ductal adenocarcinoma

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Dectin-1 plays a deleterious role in high fat diet-induced NAFLD of mice through enhancing macrophage activation

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Polychlorinated biphenyls alter hepatic m6A mRNA methylation in a mouse model of environmental liver disease

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Multiomics analysis of the impact of polychlorinated biphenyls on environmental liver disease in a mouse model

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Human centenarian–associated SIRT6 mutants modulate hepatocyte metabolism and collagen deposition in multilineage hepatic 3D spheroids

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Non-Parenchymal Cells and the Extracellular Matrix in Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease

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Metabolic benefits of 17α-estradiol in liver are partially mediated by ERβ in male mice

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Efferocytosis: An Emerging Therapeutic Strategy for Type 2 Diabetes Mellitus and Diabetes Complications

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Mechanism and Progress of Natural Products in the Treatment of NAFLD-Related Fibrosis

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Research progress of traditional Chinese medicine in improving hepatic fibrosis based on inhibiting pathological angiogenesis

Li, Z., Zhu, J., & Ouyang, H. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1303012 · Cited by 16

Hepatocellular Interactions of Potential Nutraceuticals in the Management of Inflammatory NAFLD

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Exposure to cigarette smoke precipitates simple hepatosteatosis to NASH in high-fat diet fed mice by inducing oxidative stress

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Circulating indian hedgehog is a marker of the hepatocyte-TAZ pathway in experimental NASH and is elevated in humans with NASH

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The pivotal role of dysregulated autophagy in the progression of non-alcoholic fatty liver disease

Shen, Q., Yang, M., Wang, S., Chen, X., Chen, S., Zhang, R., Xiong, Z., & Leng, Y. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1374644 · Cited by 15

Decreased LONP1 expression exacerbates MASH-induced liver fibrosis via elevated orotic acid levels

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Alanyl-Glutamine Protects Mice against Methionine- and Choline-Deficient-Diet-Induced Steatohepatitis and Fibrosis by Modulating Oxidative Stress and Inflammation

Hu, J., Zheng, Y., Ying, H., Ma, H., Li, L., & Zhao, Y. (2022) · Nutrients · doi:10.3390/nu14183796 · Cited by 16

Single-cell transcriptomics of hepatic stellate cells uncover crucial pathways and key regulators involved in non-alcoholic steatohepatitis

He, W., Huang, C., Shi, X., Wu, M., Li, H., Liu, Q., Zhang, X., Zhao, Y., & Li, X. (2022) · Endocrine Connections · doi:10.1530/ec-22-0502 · Cited by 15

Myeloid-specific ablation of Basp1 ameliorates diet-induced NASH in mice by attenuating pro-inflammatory signaling

Meng, Z., Zhou, L., Hong, S., Qiu, X., Chen, Z., Liu, T., Inoki, K., & Lin, J. D. (2023) · Hepatology · doi:10.1097/hep.0000000000000537 · Cited by 16

Prospective therapeutics for intestinal and hepatic fibrosis

Li, X., Yu, M., Zhao, Q. D., & Yu, Y. (2023) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10579 · Cited by 15

6-Shogaol Ameliorates Liver Inflammation and Fibrosis in Mice on a Methionine- and Choline-Deficient Diet by Inhibiting Oxidative Stress, Cell Death, and Endoplasmic Reticulum Stress

Yang, A. Y., Kim, K., Kwon, H. H., Leem, J., & Song, J. E. (2024) · Molecules · doi:10.3390/molecules29020419 · Cited by 15

Effect of HCV eradication by DAAs on liver steatosis, carotid atherosclerosis, and associated metabolic comorbidities: A systematic review

Cespiati, A., Rodrigues, I. C., Santos, I., Policarpo, S., Carvalhana, S. C., Fracanzani, A. L., & Cortez‐Pinto, H. (2024) · Liver International · doi:10.1111/liv.15876 · Cited by 15

Diverse potential of secretome from natural killer cells and monocyte-derived macrophages in activating stellate cells

Sauer, J., Steixner-Kumar, A. A., Gabler, S., Motyka, M., Rippmann, J. F., Brosa, S., Böttner, D., Schönberger, T., Lempp, C., Frodermann, V., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1232070 · Cited by 15

Crosstalk in extrahepatic and hepatic system in NAFLD / NASH

Duan, Y., Yang, Y. Z., Zhao, S., Bai, Y., Yao, W., Gao, X., & Yin, J. (2024) · Liver International · doi:10.1111/liv.15967 · Cited by 16

MCLR-elicited hepatic fibrosis and carcinogenic gene expression changes persist in rats with diet-induced nonalcoholic steatohepatitis through a 4-week recovery period

Arman, T., Baron, J. A., Lynch, K. D., White, L. A., Aldan, J., & Clarke, J. (2021) · Toxicology · doi:10.1016/j.tox.2021.153021 · Cited by 15

Activation of the NLRP3 inflammasome by CCl4 exacerbates hepatopathogenic diet-induced experimental NASH

Vargas-Pozada, E. E., Ramos‐Tovar, E., Rodríguez-Callejas, J. D., Cardoso-Lezama, I., Galindo‐Gómez, S., Gil-Becerril, K. M., Vásquez-Garzón, V. R., Arellanes‐Robledo, J., Tsutsumi, V., Villa‐Treviño, S., et al. (2022) · Annals of Hepatology · doi:10.1016/j.aohep.2022.100780 · Cited by 15

Gut microbiota heterogeneity in non-alcoholic fatty liver disease: a narrative review of drivers, mechanisms, and clinical relevance

Guo, Y., Zhang, N., & Pei, D. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1645298 · Cited by 15

The many pathways driving liver inflammation in MASH

Tilg, H., Adolph, T. E., Romeo, S., & Loomba, R. S. (2026) · Cell Metabolism · doi:10.1016/j.cmet.2026.02.018 · Cited by 17

Hepatocyte CD36 protects mice from NASH diet-induced liver injury and fibrosis via blocking N1ICD production

Li, Y., Zhang, L., Jiao, J., Ding, Q., Li, Y., Zhao, Z., Luo, J., Chen, Y., Ruan, X. Z., & Zhao, L. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166800 · Cited by 16

Chronic systemic inflammation predicts long-term mortality among patients with fatty liver disease: Data from the National Health and Nutrition Examination Survey 2007–2018

Pan, X., Lv, J., Liu, M., Li, Y., Zhang, Y., Zhang, R., Liu, J., Sun, C., & Guo, H. (2024) · PLoS ONE · doi:10.1371/journal.pone.0312877 · Cited by 14

ANGPTL4 induces Kupffer cell M2 polarization to mitigate acute rejection in liver transplantation

Huang, W., Jiang, L., Jiang, Y., Li, S., Liu, W., Zong, K., Peng, D., Wu, Z., & Huang, Z. (2025) · Scientific Reports · doi:10.1038/s41598-024-81832-x · Cited by 16

Transient Receptor Potential Vanilloid-1 (TRPV1) Alleviates Hepatic Fibrosis via TGF-β Signaling

Qian, K., Lei, X., Liu, G., Fang, Y., Xie, C., Wu, X., Liu, Q., Liu, G., Cao, Z., Zhang, J., et al. (2022) · Disease Markers · doi:10.1155/2022/3100943 · Cited by 14

Bariatric surgery for diabetic comorbidities: A focus on hepatic, cardiac and renal fibrosis

Ding, H., Zhang, Y., Ma, X., Zhang, Z., Xu, Q., Liu, C., Li, B., Dong, S., Li, L., Zhu, J., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1016635 · Cited by 16

Mechanisms of Action of Mesenchymal Stem Cells in Metabolic-Associated Fatty Liver Disease

Yi, S., Cong, Q., Zhu, Y., & Xu, Q. (2023) · Stem Cells International · doi:10.1155/2023/3919002 · Cited by 15

Role of B Cell-Activating Factor in Fibrosis Progression in a Murine Model of Non-Alcoholic Steatohepatitis

Kanemitsu‐Okada, K., Abe, M., Nakamura, Y., Miyake, T., Watanabe, T., Yoshida, O., Koizumi, Y., Hirooka, M., Tokumoto, Y., Matsuura, B., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032509 · Cited by 15

LEADS – a comprehensive human liver-on-a-chip for non-alcoholic steatohepatitis (NASH) drug testing

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Non-parenchymal cells: key targets for modulating chronic liver diseases

Yang, T., Gu, Z., Feng, J., Shan, J., Qian, C., & Zhuang, N. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1576739 · Cited by 16

Identifying a distinct fibrosis subset of NAFLD via molecular profiling and the involvement of profibrotic macrophages

He, W., Huang, Y., Shi, X., Wang, Q., Wu, M., Li, H., Liu, Q., Zhang, X., Huang, C., & Li, X. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04300-6 · Cited by 13

Abnormal metabolism in hepatic stellate cells: Pandora's box of MAFLD related hepatocellular carcinoma

Sun, Y.-D., Zhang, H., Li, Y., & Han, J. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189086 · Cited by 13

Notoginsenoside R1 targets PPAR-γ to inhibit hepatic stellate cell activation and ameliorates liver fibrosis

Guo, C., Lai, L., Ma, B., Huang, Q., & Wang, Z. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.113992 · Cited by 13

Vitamin D Mitigates Hepatic Fat Accumulation and Inflammation and Increases SIRT1/AMPK Expression in AML-12 Hepatocytes

Chang, E. (2024) · Molecules · doi:10.3390/molecules29061401 · Cited by 19

A long‐acting FGF21 attenuates metabolic dysfunction‐associated steatohepatitis‐related fibrosis by modulating NR4A1‐mediated Ly6C phenotypic switch in macrophages

Ji, Y. R., Duan, Y., Li, Y., Lu, Q., Liu, D., Yang, Y., Chang, R., Jing, T., Yao, W., Yin, J., et al. (2024) · British Journal of Pharmacology · doi:10.1111/bph.16378 · Cited by 14

Sterol O-acyltransferase (SOAT/ACAT) activity is required to form cholesterol crystals in hepatocyte lipid droplets

Bairos, J. A., Njoku, U. C., Zafar, M., Akl, M. G., Li, L., Parlakgül, G., Arruda, A. P., & Widenmaier, S. B. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2024.159512 · Cited by 13

New peripherally-restricted CB1 receptor antagonists, PMG-505–010 and −013 ameliorate obesity-associated NAFLD and fibrosis

Yang, H., Park, M., Lee, J. H., Kim, B.-K., Moon, C. S., Bae, S., Kim, Y., Lee, H., & Park, C. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117501 · Cited by 14

Targeting endoplasmic reticulum proteostasis in liver fibrosis: From signaling mechanisms to therapeutic opportunities

Kong, Y., Chen, Z., Nie, Z., & Chen, W. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107823 · Cited by 17

Phosphate Groups in the Lipid A Moiety Determine the Effects of LPS on Hepatic Stellate Cells: A Role for LPS-Dephosphorylating Activity in Liver Fibrosis

Schippers, M., Post, E., Eichhorn, I. A., Langeland, J., Beljaars, L., Malo, M. S., Hodin, R. A., Millán, J. L., Popov, Y. V., Schuppan, D., et al. (2020) · Cells · doi:10.3390/cells9122708 · Cited by 13

Inflammatory and Non-Inflammatory Mechanisms Controlling Cirrhosis Development

Sánchez, P. S., Rigual, M. D. M., & Djouder, N. (2021) · Cancers · doi:10.3390/cancers13205045 · Cited by 13

Extracellular Vesicles from Steatotic Hepatocytes Provoke Pro-Fibrotic Responses in Cultured Stellate Cells

Koenen, M. T., Brandt, E. F., Kaczor, D., Caspers, T., Heinzmann, A. C. A., Fischer, P., Heinrichs, D., Wirtz, T. H., Trautwein, C., Koenen, R. R., et al. (2022) · Biomolecules · doi:10.3390/biom12050698 · Cited by 13

Identify Functional lncRNAs in Nonalcoholic Fatty Liver Disease by Constructing a ceRNA Network

Xue, W., Zhang, J., Zhu, Y., & Huang, W. (2022) · ACS Omega · doi:10.1021/acsomega.2c01801 · Cited by 13

L. Plantarum and L. Lactis as a Promising Agent in Treatment of Inflammatory Bowel Disease and Colorectal Cancer

Javid, H., Oryani, M. A., Akbari, S., Amiriani, T., Ravanbakhsh, S., Rezagholinejad, N., Afshari, A. R., & Karimi‐Shahri, M. (2023) · Future Microbiology · doi:10.2217/fmb-2023-0076 · Cited by 13

Targeting of Secretory Proteins as a Therapeutic Strategy for Treatment of Nonalcoholic Steatohepatitis (NASH)

Kim, K., & Kim, K. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072296 · Cited by 13

Advancements in the understanding of mechanisms of the IL-6 family in relation to metabolic-associated fatty liver disease

Liu, J., Wang, T., Yang, F., & Pubu, C. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1642436 · Cited by 13

Mitochondrial GRIM19 Loss Induces Liver Fibrosis through NLRP3/IL33 Activation via Reactive Oxygen Species/NF-кB Signaling

Xu, X., Feng, J., Wang, X., Zeng, X., Luo, Y., He, X., Yang, M., Lv, T., Feng, Z., Bao, L., et al. (2024) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2023.00562 · Cited by 12

tBHQ mitigates fatty liver ischemia–reperfusion injury by activating Nrf2 to attenuate hepatocyte mitochondrial damage and macrophage STING activation

Wu, D., Xu, J., Zhang, Y., Wang, Y., Bai, Y., Zhan, X., Gao, Y., Hu, H., Hu, H., Wang, P., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112515 · Cited by 12

The Liver in Diabetes and Metabolic Syndrome

Mahmoud, M. C., & Abdelmalek, M. F. (2025) · Clinics in Liver Disease · doi:10.1016/j.cld.2025.04.003 · Cited by 14

Macrophages as a source of fibrosis biomarkers for non-alcoholic fatty liver disease

Yoshio, S., & Kanto, T. (2021) · Immunological Medicine · doi:10.1080/25785826.2020.1868664 · Cited by 13

Edaravone protects against liver fibrosis progression via decreasing the IL-1β secretion of macrophages

Zhao, R., Zhao, H., Guo, Q., Mu, Y., Zhang, J., Su, Y., & Han, Q. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.110251 · Cited by 12

Current perspectives on the pathophysiology of metabolic associated fatty liver disease: are macrophages a viable target for therapy?

Kjær, M. B., George, J., Kazankov, K., & Grønbæk, H. (2020) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2020.1817740 · Cited by 13

Recent Advancements in Known and Emerging Risk Factors of Hepatocellular Carcinoma

Hussain, M. M., Bi, F., Wang, J., Zhai, A., Li, F., & Hu, H. (2025) · Cancer Medicine · doi:10.1002/cam4.71330 · Cited by 11

Diethyldithiocarbamate inhibits the activation of hepatic stellate cells via PPARα/FABP1 in mice with non-alcoholic steatohepatitis

Sun, X., Yu, Q., Kang, B., Zhao, X., Li, H., Liu, H., Liu, L., Wang, P., Cong, M., & Liu, T. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.12.039 · Cited by 11

Ductular reaction in non-alcoholic fatty liver disease: When Macbeth is perverted

He, Y.-H., Pan, J., Xu, L., Gu, T., & Chen, Y. (2023) · World Journal of Hepatology · doi:10.4254/wjh.v15.i6.725 · Cited by 11

Development of hepatic steatosis in male and female mule ducks after respective force-feeding programs

Atallah, E., Trehiou, S., Alquier‐Bacquie, V., Lasserre, F., Arroyo, J., Molette, C., & Rémignon, H. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1392968 · Cited by 11

Network Pharmacology and Molecular Docking Integrated with Molecular Dynamics Simulations Investigate the Pharmacological Mechanism of Yinchenhao Decoction in the Treatment of Non-alcoholic Fatty Liver Disease

Yang, R., Jiang, D., Xu, H., Yang, H., Feng, L., Wu, Q., & Xing, Y. (2024) · Current Computer - Aided Drug Design · doi:10.2174/0115734099305489240702075128 · Cited by 12

A New Target for Hepatic Fibrosis Prevention and Treatment: The Warburg Effect

Pan, M., Li, H. Z., & Shi, X. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2909321 · Cited by 13

Short-term exposure to low doses of aflatoxin B1 aggravates nonalcoholic steatohepatitis by TLR4-mediated necroptosis

Zeng, J., Chen, L., Tang, J., Xue, J., Wang, Q., Feng, X., Chen, X., Huang, K., & Gan, F. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.11.027 · Cited by 11

Ablation of Hepatic Asah1 Gene Disrupts Hepatic Lipid Homeostasis and Promotes Fibrotic Nonalcoholic Steatohepatitis in Mice

Zuo, R. M., Wang, M., Wang, Y., Shentu, Y., Moura, A. K., Zhou, Y., Roudbari, K., Hu, J. Z., Li, P., Hao, J., et al. (2024) · American Journal Of Pathology · doi:10.1016/j.ajpath.2024.11.003 · Cited by 11

Systemic therapy plus HAIC versus systemic therapy for hepatocellular carcinoma: a systematic review and meta-analysis

Lü, D., Li, H., Sun, P., Tian, J., Jiao, K., Cao, Q., Wang, Y., Jia, J., He, Q., Peng, S.-X., et al. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000002326 · Cited by 13

Chronic inflammation as a molecular basis of nonalcoholic steatohepatitis: role of macrophages and fibroblasts in the liver.

Itoh, M., Ogawa, Y., & Suganami, T. (2020) · Europe PMC (PubMed Central) · doi:10.18999/nagjms.82.3.391 · Cited by 5

Role of Hepatic Progenitor Cells in Nonalcoholic Fatty Liver Disease Development: Cellular Cross-Talks and Molecular Networks

Carpino, G., Renzi, A., Onori, P., & Gaudio, E. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141020112 · Cited by 69

Hepatocyte Injury and Hepatic Stem Cell Niche in the Progression of Non-Alcoholic Steatohepatitis

Overi, D., Carpino, G., Franchitto, A., Onori, P., & Gaudio, E. (2020) · Cells · doi:10.3390/cells9030590 · Cited by 62

The cellular pathways of liver fibrosis in non-alcoholic steatohepatitis

Méndez‐Sánchez, N., Valencia-Rodríguez, A., Coronel-Castillo, C. E., Vera-Barajas, A., Contreras-Carmona, J., Ponciano‐Rodríguez, G., & Zamora‐Valdés, D. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2020.02.184 · Cited by 55

Fibrogenic Pathways in Metabolic Dysfunction Associated Fatty Liver Disease (MAFLD)

Subramanian, P., Hampe, J., Tacke, F., & Chavakis, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23136996 · Cited by 35