CoChat
Sign Up
Cited by 143

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Protective Role of Spermidine in Colitis and Colon Carcinogenesis

Gobert, Alain P., Latour, Yvonne L., Asim, Mohammad, Barry, Daniel P., Allaman, Margaret M., Finley, Jordan L., Smith, Thaddeus M., McNamara, Kara M., Singh, Kshipra, Sierra, Johanna C., Delgado, Alberto G., Luis, Paula B., Schneider, Claus, Washington, M. Kay, Piazuelo, M. Blanca, Zhao, Shilin, Coburn, Lori A., Wilson, Keith T.·2022·Gastroenterology
DOI 10.1053/j.gastro.2021.11.005PMC PMC8881368
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1053/j.gastro.2021.11.005

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 4 references

Research works printed but not linked: 65

  1. Dahlhamer, 2016, Prevalence of inflammatory bowel disease among adults aged >/=18 years-United States, 2015, Morb Mortal Wkly Rep, 65, 1166, 10.15585/mmwr.mm6542a3 · DOI
  2. Singh, 2017, Pivot to Asia: inflammatory bowel disease burden, Intest Res, 15, 138, 10.5217/ir.2017.15.1.138 · DOI
  3. Mattiuzzi, 2019, Concise update on colorectal cancer epidemiology, Ann Transl Med, 7, 609, 10.21037/atm.2019.07.91 · DOI
  4. Pegg, 2016, Functions of polyamines in mammals, J Biol Chem, 291, 14904, 10.1074/jbc.R116.731661 · DOI
  5. Wang, 2001, Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure, Cancer Res, 61, 5370
  6. Gobert, 2018, Distinct immunomodulatory effects of spermine oxidase in colitis induced by epithelial injury or infection, Front Immunol, 9, 1242, 10.3389/fimmu.2018.01242 · DOI
  7. Kingsnorth, 1983, Effects of alpha-difluoromethylornithine and 5-fluorouracil on the proliferation of a human colon adenocarcinoma cell line, Cancer Res, 43, 4035
  8. Ray, 2001, Polyamine depletion arrests growth of IEC-6 and Caco-2 cells by different mechanisms, Am J Physiol Gastrointest Liver Physiol, 281, G37, 10.1152/ajpgi.2001.281.1.G37 · DOI
  9. Erdman, 1999, APC-dependent changes in expression of genes influencing polyamine metabolism, and consequences for gastrointestinal carcinogenesis, in the Min mouse, Carcinogenesis, 20, 1709, 10.1093/carcin/20.9.1709 · DOI
  10. Meyskens, 2008, Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial, Cancer Prev Res (Phila), 1, 32, 10.1158/1940-6207.CAPR-08-0042 · DOI
  11. Sinicrope, 2019, Efficacy of difluoromethylornithine and aspirin for treatment of adenomas and aberrant crypt foci in patients with prior advanced colorectal neoplasms, Cancer Prev Res (Phila), 12, 821, 10.1158/1940-6207.CAPR-19-0167 · DOI
  12. Lynch, 2016, An international randomised trial of celecoxib versus celecoxib plus difluoromethylornithine in patients with familial adenomatous polyposis, Gut, 65, 286, 10.1136/gutjnl-2014-307235 · DOI
  13. Vargas, 2015, Dietary polyamine intake and colorectal cancer risk in postmenopausal women, Am J Clin Nutr, 102, 411, 10.3945/ajcn.114.103895 · DOI
  14. Zahedi, 2017, Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury, PLoS One, 12, 10.1371/journal.pone.0184570 · DOI
  15. Sierra, 2020, Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling, Oncogene, 39, 4465, 10.1038/s41388-020-1304-6 · DOI
  16. Goulding, 2021, Comparative efficacy of two types of antibiotic mixtures in gut flora depletion in female C57BL/6 mice, Comp Med, 71, 203, 10.30802/AALAS-CM-21-000023 · DOI
  17. Hardbower, 2017, EGFR-mediated macrophage activation promotes colitis-associated tumorigenesis, Oncogene, 36, 3807, 10.1038/onc.2017.23 · DOI
  18. Singh, 2018, Ornithine decarboxylase in macrophages exacerbates colitis and promotes colitis-associated colon carcinogenesis by impairing M1 immune responses, Cancer Res, 78, 4303, 10.1158/0008-5472.CAN-18-0116 · DOI
  19. Coburn, 2019, Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis, Oncogene, 38, 1067, 10.1038/s41388-018-0492-9 · DOI
  20. Feng, 2013, Sox9 induction, ectopic Paneth cells, and mitotic spindle axis defects in mouse colon adenomatous epithelium arising from conditional biallelic Apc inactivation, Am J Pathol, 183, 493, 10.1016/j.ajpath.2013.04.013 · DOI
  21. Triner, 2019, Neutrophils restrict tumor-associated microbiota to reduce growth and invasion of colon tumors in mice, Gastroenterology, 156, 1467, 10.1053/j.gastro.2018.12.003 · DOI
  22. Powell, 1992, APC mutations occur early during colorectal tumorigenesis, Nature, 359, 235, 10.1038/359235a0 · DOI
  23. Bachmanov, 2002, Food intake, water intake, and drinking spout side preference of 28 mouse strains, Behav Genet, 32, 435, 10.1023/A:1020884312053 · DOI
  24. Hardbower, 2017, Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications, Proc Natl Acad Sci U S A, 114, E751, 10.1073/pnas.1614958114 · DOI
  25. Coburn, 2013, High-throughput multi-analyte Luminex profiling implicates eotaxin-1 in ulcerative colitis, PloS One, 8, 10.1371/journal.pone.0082300 · DOI
  26. Coburn, 2016, L-arginine availability and metabolism is altered in ulcerative colitis, Inflamm Bowel Dis, 22, 1847, 10.1097/MIB.0000000000000790 · DOI
  27. Willers, 2020, S100A8 and S100A9 are important for postnatal development of gut microbiota and immune system in mice and infants, Gastroenterology, 159, 2130, 10.1053/j.gastro.2020.08.019 · DOI · Paper page
  28. Singh, 2019, Dietary arginine regulates severity of experimental colitis and affects the colonic microbiome, Front Cell Infect Microbiol, 9, 66, 10.3389/fcimb.2019.00066 · DOI
  29. Eisenberg, 2016, Cardioprotection and lifespan extension by the natural polyamine spermidine, Nat Med, 22, 1428, 10.1038/nm.4222 · DOI · Paper page
  30. Kiechl, 2018, Higher spermidine intake is linked to lower mortality: a prospective population-based study, Am J Clin Nutr, 108, 371, 10.1093/ajcn/nqy102 · DOI
  31. Levin, 1987, Phase I-II study of eflornithine and mitoguazone combined in the treatment of recurrent primary brain tumors, Cancer Treat Rep, 71, 459
  32. Simoneau, 2008, The effect of difluoromethylornithine on decreasing prostate size and polyamines in men: results of a year-long phase IIb randomized placebo-controlled chemoprevention trial, Cancer Epidemiol Biomarkers Prev, 17, 292, 10.1158/1055-9965.EPI-07-0658 · DOI
  33. Kreul, 2012, A phase III skin cancer chemoprevention study of DFMO: long-term follow-up of skin cancer events and toxicity, Cancer Prev Res (Phila), 5, 1368, 10.1158/1940-6207.CAPR-12-0233 · DOI
  34. Tutton, 1986, Comparison of the effects of an ornithine decarboxylase inhibitor on the intestinal epithelium and on intestinal tumors, Cancer Res, 46, 6091
  35. Saydjari, 1991, Differential sensitivity of various human tumors to inhibition of polyamine biosynthesis in vivo, Int J Cancer, 47, 44, 10.1002/ijc.2910470109 · DOI
  36. Alhonen, 1995, Life-long over-expression of ornithine decarboxylase (ODC) gene in transgenic mice does not lead to generally enhanced tumorigenesis or neuronal degeneration, Int J Cancer, 63, 402, 10.1002/ijc.2910630317 · DOI
  37. Chen, 2008, Tissue levels of arsenicals and skin tumor response following administration of monomethylarsonous acid and arsenite to K6/ODC mice, J Environ Pathol Toxicol Oncol, 27, 43, 10.1615/JEnvironPatholToxicolOncol.v27.i1.50 · DOI
  38. Chaturvedi, 2015, Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase, Oncogene, 34, 3429, 10.1038/onc.2014.273 · DOI
  39. Yue, 2017, Spermidine prolongs lifespan and prevents liver fibrosis and hepatocellular carcinoma by activating MAP1S-mediated autophagy, Cancer Res, 77, 2938, 10.1158/0008-5472.CAN-16-3462 · DOI
  40. Gobert, 2004, Protective role of arginase in a mouse model of colitis, J Immunol, 173, 2109, 10.4049/jimmunol.173.3.2109 · DOI
  41. Goodwin, 2011, Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis, Proc Natl Acad Sci U S A, 108, 15354, 10.1073/pnas.1010203108 · DOI · Paper page
  42. Hashimoto, 2012, Human neutrophil peptide-1 aggravates dextran sulfate sodium-induced colitis, Inflamm Bowel Dis, 18, 667, 10.1002/ibd.21855 · DOI
  43. Bousserouel, 2010, Identification of gene expression profiles correlated to tumor progression in a preclinical model of colon carcinogenesis, Int J Oncol, 36, 1485
  44. Tschurtschenthaler, 2014, Type I interferon signalling in the intestinal epithelium affects Paneth cells, microbial ecology and epithelial regeneration, Gut, 63, 1921, 10.1136/gutjnl-2013-305863 · DOI
  45. Williams, 2017, Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease, PLoS One, 12
  46. Taman, 2018, Transcriptomic landscape of treatment-naïve ulcerative colitis, J Crohns Colitis, 12, 327, 10.1093/ecco-jcc/jjx139 · DOI
  47. Jeong, 2019, Defensin alpha 6 (DEFA6) is a prognostic marker in colorectal cancer, Cancer Biomark, 24, 485, 10.3233/CBM-182221 · DOI
  48. Wehkamp, 2005, Reduced Paneth cell alpha-defensins in ileal Crohn’s disease, Proc Natl Acad Sci U S A, 102, 18129, 10.1073/pnas.0505256102 · DOI
  49. Salzman, 2010, Enteric defensins are essential regulators of intestinal microbial ecology, Nat Immunol, 11, 76, 10.1038/ni.1825 · DOI · Paper page
  50. Tang, 2018, Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing Treg cells through modification of the intestinal microbiota, Nat Immunol, 19, 755, 10.1038/s41590-018-0134-y · DOI
  51. Ou, 2020, alpha-Defensins promote Bacteroides colonization on mucosal reservoir to prevent antibiotic-induced dysbiosis, Front Immunol, 11, 2065, 10.3389/fimmu.2020.02065 · DOI
  52. Hirano, 2018, Comparison of the microbial community structure between inflamed and non-inflamed sites in patients with ulcerative colitis, J Gastroenterol Hepatol, 33, 1590, 10.1111/jgh.14129 · DOI
  53. Frank, 2007, Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases, Proc Natl Acad Sci U S A, 104, 13780, 10.1073/pnas.0706625104 · DOI · Paper page
  54. Mukhopadhya, 2012, IBD-what role do Proteobacteria play?, Nat Rev Gastroenterol Hepatol, 9, 219, 10.1038/nrgastro.2012.14 · DOI · Paper page
  55. Schwarz, 2018, Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline, Aging (Albany NY), 10, 19, 10.18632/aging.101354 · DOI
  56. Coburn, 2013, High-throughput multi-analyte Luminex profiling implicates eotaxin-1 in ulcerative colitis, PloS One, 8, 10.1371/journal.pone.0082300 · DOI
  57. Coburn, 2016, L-arginine availability and metabolism is altered in ulcerative colitis, Inflamm Bowel Dis, 22, 1847, 10.1097/MIB.0000000000000790 · DOI
  58. Chen, 2018, Fastp: an ultra-fast all-in-one FASTQ preprocessor, Bioinformatics, 34, i884, 10.1093/bioinformatics/bty560 · DOI · Paper page
  59. Patro, 2017, Salmon provides fast and bias-aware quantification of transcript expression, Nat Methods, 14, 417, 10.1038/nmeth.4197 · DOI · Paper page
  60. Love, 2020, Tximeta: reference sequence checksums for provenance identification in RNA-seq, PLoS Comput Biol, 16, 10.1371/journal.pcbi.1007664 · DOI
  61. Love, 2014, Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2, Genome Biol, 15, 550, 10.1186/s13059-014-0550-8 · DOI · Paper page
  62. Schloss, 2009, Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities, Appl Environ Microbiol, 75, 7537, 10.1128/AEM.01541-09 · DOI · Paper page
  63. Pruesse, 2007, SILVA: a comprehensive online resource for quality checked and aligned ribosomal RNA sequence data compatible with ARB, Nucleic Acids Res, 35, 7188, 10.1093/nar/gkm864 · DOI
  64. Cole, 2009, The Ribosomal Database Project: improved alignments and new tools for rRNA analysis, Nucleic Acids Res, 37, D141, 10.1093/nar/gkn879 · DOI
  65. Rognes, 2016, VSEARCH: a versatile open source tool for metagenomics, PeerJ, 4, 10.7717/peerj.2584 · DOI

Cited by

Sorted by citations

Metadata

Authors
Gobert, A. P., Latour, Y. L., Asim, M., Barry, D. P., Allaman, M. M., Finley, J. L., Smith, T. M., McNamara, K. M., Singh, K., Sierra, J. C., Delgado, A. G., Luis, P. B., Schneider, C., Washington, M. K., Piazuelo, M. B., Zhao, S., Coburn, L. A., & Wilson, K. T.
ORCID
Venue
Gastroenterology
Publisher
Elsevier BV
Published
2022-03
Volume
162
Issue
3
Pages
813-827.e8
ISSN
0016-5085
DOI
10.1053/j.gastro.2021.11.005
PMC
PMC8881368
Cited by
143
References
4
Language
en
Update notices
erratum (2022-06-01)
Licence
Funders
  • Crohn's and Colitis Foundation of America
  • National Institutes of Health (R01DK128200)
  • NIAID (T32AI138932)
  • U.S. Department of Defense (W81XWH-21-1-0617)
  • CURE Childhood Cancer
  • NCCIH (R01AT004821)
  • U.S. Department of Veterans Affairs (I01BX001453, I01CX002171, 1IK2BX002126, I01BX004366, T32AI138932)
  • NIDDK
  • NCI (P01CA116087, R01CA190612, T32CA009592, P01CA028842)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review