Science-Driven Nutritional Interventions for the Prevention and Treatment of Cancer
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Abstract
In population studies, dietary patterns clearly influence the development, progression, and therapeutic response of cancers. Nonetheless, interventional dietary trials have had relatively little impact on the prevention and treatment of malignant disease. Standardization of nutritional interventions combined with high-level mode-of-action studies holds the promise of identifying specific entities and pathways endowed with antineoplastic properties. Here, we critically review the effects of caloric restriction and more specific interventions on macro- and micronutrients in preclinical models as well as in clinical studies. We place special emphasis on the prospect of using defined nutrition-relevant molecules to enhance the efficacy of established anticancer treatments. Significance: The avoidance of intrinsically hypercaloric and toxic diets contributes to the prevention and cure of cancer. In addition, specific diet-induced molecules such as ketone bodies and micronutrients, including specific vitamins, have drug-like effects that are clearly demonstrable in preclinical models, mostly in the context of immunotherapies. Multiple trials are underway to determine the clinical utility of such molecules.
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Polyamines, including spermidine, are naturally occurring in foods and can be synthesized by the gut microbiome.
“Polyamines, including spermidine, are naturally occurring in foods and can be synthesized by the gut microbiome, suggesting a potential beneficial role for spermidine-enriched diets35.”
From Longitudinal gut microbiome changes in immune checkpoint blockade-treated advanced melanoma (2024) · cites this paper as [35]
Spermidine-enriched diets may have a potential beneficial role.
“suggesting a potential beneficial role for spermidine-enriched diets35.”
From Longitudinal gut microbiome changes in immune checkpoint blockade-treated advanced melanoma (2024) · cites this paper as [35]
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Sorted by citations
Longitudinal gut microbiome changes in immune checkpoint blockade-treated advanced melanoma
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Self-citation
- Authors
- Montégut, L., de Cabo, R., Zitvogel, L., & Kroemer, G.
- Affiliations
- Inserm (FR)
- 4Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland.
- Venue
- Cancer Discovery
- Published
- 2022-08-23
- Volume
- 12
- Issue
- 10
- Pages
- 2258-2279
- ISSN
- 2159-8274 (ISSN-L)
- 2159-8290
- PMC
- PMC10749912
- OpenAlex
- W4292731398
- Cited by
- 38
- References
- 199
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 13 · 2023: 11 · 2022: 3
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cancer Discovery (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- Ligue Contre le Cancer (Equipe labellisé, e)
- Agence Nationale de la Recherche (Projet blanc AMMICa US23/CNRS UMS3655)
- Cancéropôle ile-de-France
- Investissement d'avenir (Labex Immuno-Onco, ANR-18-IDEX-0001, RHU Immunolige, IdEx Université, de Paris ANR-18-IDEX-0001)
- Gustave Roussy (Odyssea)
- European Union Horizon 2020 Project (Oncobiome, Crimson)
- Fondation Carrefour (NA)
- Institut National Du Cancer (NA)
- Institut Universitaire de France (NA)
- Mark Foundation (ASPIRE Award)
- Seerave Foundation (NA)
- SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE)
- SIRIC Cancer Research and Personalized Medicine (CARPEM)
- Elior (NA)
- Topics
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Keywords
- dietary intervention, cancer prevention, cancer therapy, caloric restriction, dietary habits, micronutrients, vitamins, ketone bodies, anticancer agents, immunotherapy, preclinical models, mechanism of action
- MeSH terms
- Humans, Ketone Bodies, Neoplasms, Vitamins, Micronutrients
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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