The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Incubation Phase of Acute Hepatitis B in Man: Dynamic of Cellular Immune Mechanisms
Open accessAbstract
After hepatitis B virus (HBV) infection, liver injury and viral control have been thought to result from lysis of infected hepatocytes by virus–specific cytotoxic T cells. Patients are usually studied only after developing significant liver injury, and so the viral and immune events during the incubation phase of disease have not been defined. During a single–source outbreak of HBV infection, we identified patients before the onset of symptomatic hepatitis. The dynamics of HBV replication, liver injury, and HBV–specific CD8+ and CD4+ cell responses were investigated from incubation to recovery. Although a rise in alanine transaminase (ALT) levels was present at the time of the initial fall in HBV–DNA levels, maximal reduction in virus level occurred before significant liver injury. Direct ex vivo quantification of HBV–specific CD4+ and CD8+ cells, by using human leukocyte antigen (HLA) class I tetramers and intracellular cytokine staining, showed that adaptive immune mechanisms are present during the incubation phase, at least 4 weeks before symptoms. The results suggest that the pattern of reduction in HBV replication is not directly proportional to tissue injury during acute hepatitis B in humans. Furthermore, because virus–specific immune responses and significant reductions in viral replication are seen during the incubation phase, it is likely that the immune events central to viral control occur before symptomatic disease.
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Cites
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Cited by
Thimme, R., Wieland, S., Steiger, C., Ghrayeb, J., Reimann, K. A., Purcell, R. H., & Chisari, F. V. (2003) · Journal of Virology · doi:10.1128/jvi.77.1.68-76.2003 · Cited by 979
Immunobiology and pathogenesis of hepatitis B virus infection
Iannacone, M., & Guidotti, L. G. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-021-00549-4 · Cited by 520
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Self-citationLiver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases
Gao, B., Radaeva, S., & Park, O. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0309135 · Cited by 377
Temporal Analysis of Early Immune Responses in Patients With Acute Hepatitis B Virus Infection
Dunn, C., Peppa, D., Khanna, P., Nebbia, G., Jones, M., Brendish, N., Lascar, R. M., Brown, D., Gilson, R. J., Tedder, R. J., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.06.054 · Cited by 362
Self-citation
Metadata
- Authors
- Webster, G. J. M., Reignat, S., Maini, M. K., Whalley, S. A., Ogg, G. S., King, A., Brown, D., Amlot, P. L., Williams, R., Vergani, D., Dusheiko, G. M., & Bertoletti, A.
- Venue
- Hepatology
- Published
- 2000-11
- Volume
- 32
- Issue
- 5
- Pages
- 1117-1124
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2164439917
- Cited by
- 414
- References
- 24
- FWCI
- 10.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Webster, G. J. M., Reignat, S., Maini, M. K., Whalley, S. A., Ogg, G. S., King, A., Brown, D., Amlot, P. L., Williams, R., Vergani, D., Dusheiko, G. M., & Bertoletti, A. (2000). Incubation Phase of Acute Hepatitis B in Man: Dynamic of Cellular Immune Mechanisms. Hepatology. https://doi.org/10.1053/jhep.2000.19324
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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