The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Differentiation of Embryonic Stem Cells Into Hepatocytes: Biological Functions and Therapeutic Application
Open accessAbstract
Embryonic stem (ES) cells provide a unique source for tissue regeneration. We examined whether mouse ES cells can efficiently differentiate into transplantable hepatocytes. ES cells were implanted into mouse livers 24 hours after carbon tetrachloride intoxication; ES–derived cells with several hepatocyte–cell–markers were generated. They were able to grow in vitro and showed morphology consistent with typical mature hepatocytes and expressed hepatocyte–specific genes. After transplantation into the carbon tetrachloride–injured mouse liver, ES–derived green fluorescent protein–positive cells were incorporated into liver tissue and rescued mice from hepatic injury. No teratoma formation was observed in the transplant recipients. In conclusion, ES cells can provide a valuable tool for studying the molecular basis for differentiation of hepatocytes and form the basis for cell therapies.
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Cites
Liver from bone marrow in humans
Theise, N. D., Nimmakayalu, M., Gardner, R., Illei, P. B., Morgan, G., Teperman, L., Henegariu, O., & Krause, D. S. (2000) · Hepatology · doi:10.1053/jhep.2000.9124 · Cited by 1,210
Cited by
Embryonic Stem Cells: Prospects for Developmental Biology and Cell Therapy
Wobus, A. M., & Boheler, K. R. (2005) · Physiological Reviews · doi:10.1152/physrev.00054.2003 · Cited by 782
Liver regeneration and repair: Hepatocytes, progenitor cells, and stem cells
Fausto, N. (2004) · Hepatology · doi:10.1002/hep.20214 · Cited by 720
Adipose tissue-derived mesenchymal stem cells as a source of human hepatocytes
Banas, A., Teratani, T., Yamamoto, Y., Tokuhara, M., Takeshita, F., Quinn, G., Okochi, H., & Ochiya, T. (2007) · Hepatology · doi:10.1002/hep.21704 · Cited by 555
Self-citationDifferentiation of human embryonic stem cells into hepatocytes in 2D and 3D culture systems in vitro
Baharvand, H., Hashemi, S. M., Kazemi Ashtiani, S., & Farrokhi, A. (2006) · The International Journal of Developmental Biology · doi:10.1387/ijdb.052072hb · Cited by 429
Human hepatocyte transplantation: current experience and future challenges
Dhawan, A., Puppi, J., Hughes, R. D., & Mitry, R. R. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.44 · Cited by 362
Metadata
- Authors
- Yamamoto, H., Quinn, G., Asari, A., Yamanokuchi, H., Teratani, T., Terada, M., & Ochiya, T.
- Venue
- Hepatology
- Published
- 2003-05
- Volume
- 37
- Issue
- 5
- Pages
- 983-993
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2030648440
- Cited by
- 211
- References
- 1
- FWCI
- 6.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yamamoto, H., Quinn, G., Asari, A., Yamanokuchi, H., Teratani, T., Terada, M., & Ochiya, T. (2003). Differentiation of Embryonic Stem Cells Into Hepatocytes: Biological Functions and Therapeutic Application. Hepatology. https://doi.org/10.1053/jhep.2003.50202
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
