The influence of co-morbidity on health-related quality of life in asthma and COPD patients
Open accessAbstract
This study examines the association between somatic co-morbidity and both general and disease-specific health-related quality of life (HRQoL) in patients with asthma and chronic obstructive pulmonary disease (COPD). A cross-sectional analysis was done among 161 COPD patients and 395 asthma patients, aged 40-75 years, recruited from general practice. In the total study population, 47% had no, 32% had one, and 21% had two or more somatic co-morbid conditions, with no significant differences between asthma and COPD patients. Co-morbidity appeared to be associated with poor disease-specific HRQoL in asthma [odds ratio (OR) = 2.08 (1.37-3.18)] and with poor general HRQoL in asthma [OR = 2.96 (1.93-4.53)] and COPD [1.81 (0.91-3.60)] patients. Poorest HRQoL was found in patients with more than one co-morbid condition. Cardiac disease and hypertension were associated with poor disease-specific HRQoL in asthma. Of all co-morbid conditions, musculoskeletal disorders were most strongly associated with poor general HRQoL. Cardiac disease was found to be associated with general and disease-specific HRQoL in asthma but not in COPD. In studies on patients with asthma or COPD aged 40-75 years, co-morbidity should be treated as a determinant of HRQoL.
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- Authors
- WIJNHOVEN, H. A. H., KRIEGSMAN, D. M. W., HESSELINK, A. E., DE HAAN, M., & SCHELLEVIS, F. G.
- Affiliations
- Amsterdam Public Health (NL)
- Netherlands Institute for Health Services Research (NL)
- Venue
- Respiratory Medicine
- Publisher
- Elsevier BV
- Published
- 2003-05
- Volume
- 97
- Issue
- 5
- Pages
- 468-475
- ISSN
- 0954-6111 (ISSN-L)
- OpenAlex
- W2008473933
- Cited by
- 118
- References
- 30
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 6 · 2019: 7 · 2018: 6 · 2017: 5 · 2016: 13 · 2015: 6 · 2014: 6 · 2013: 8 · 2012: 2
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Respiratory Medicine (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- VU Research Portal (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
- Keywords
- comorbidities, health-related quality of life, asthma, chronic obstructive pulmonary disease, disease-specific quality of life, musculoskeletal disorders, heart disease, hypertension, older adults
- MeSH terms
- Adult, Aged, Asthma, Cross-Sectional Studies, Female, Health Status Indicators, Heart Diseases, Humans, Male, Middle Aged, Musculoskeletal Diseases, Netherlands, Quality of Life, Surveys and Questionnaires, Comorbidity, Logistic Models, Odds Ratio, Pulmonary Disease, Chronic Obstructive
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