Prevalence of Comorbidities in Asthma and Nonasthma Patients: A Meta-analysis
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This study compares the prevalence rates of comorbidities between asthma and nonasthma control patients reported in the literature.Literature was searched in several electronic databases. After the selection of studies by following précised eligibility criteria, meta-analyses of odds ratios were carried out with subgroup and sensitivity analyses.Eleven studies studying 117,548 asthma patients compared with 443,948 non-asthma controls were included in the meta-analysis. The prevalence of cardiovascular comorbidities (odds ratio (OR): [95% CI] 1.90 [1.70, 2.14]; P < 0.00001), cerebrovascular comorbidities (OR 1.44 [1.29, 1.60]; P < 0.00001), obesity (OR 1.51 [1.14, 2.01]; P < 0.00001), hypertension (OR 1.66 [1.47, 1.88]; P < 0.00001, diabetes (OR 1.25 [1.08, 1.44]; P < 0.00001), other metabolic and endocrine comorbidities (OR 1.60 [1.40, 1.83]; P < 0.00001), psychiatric and neurological comorbidities (OR 1.62 [1.44, 1.82]; P < 0.00001), gut and urinary comorbidities (OR 1.91 [1.47, 2.49]; P < 0.00001),), cancer (OR 1.17 [1.10, 1.25]; P < 0.00001), and respiratory comorbidities (OR 5.60 [4.22, 7.44]; P < 0.00001) were significantly higher in the asthma patients in comparison with nonasthma controls.Asthma is associated with significantly higher comorbidities including cardio-/cerebrovascular diseases, obesity, hypertension, diabetes, psychiatric and neurological comorbidities, gut and urinary conditions, cancer, and respiratory problems other than asthma. Respiratory comorbidities are found 5 times more prevalent in asthma than in non-asthma patients.
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Physical health factors, such as high BMI and co-occurring health conditions, were extremely common in people with asthma, consistent with existing literature.
“Physical health factors, such as high BMI and co-occurring health conditions, were extremely common in people with asthma, consistent with existing literature.16”
From A systematic review of psychological, physical health factors, and quality of life in adult asthma (2019) · cites this paper as [16]
This was found throughout the included papers and is consistent with previous research.
“This was found throughout the included papers and is consistent with previous research (e.g. refs 8,16).”
From A systematic review of psychological, physical health factors, and quality of life in adult asthma (2019) · cites this paper as [16]
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Role of 5-HT2 Receptors Family in the Allergy-Induced Increased Aorta Contractile Responses to 5-HTPreprint
Campos‐Bedolla, P., Torrejón-González, E. G., Mendoza-Mejía, D., Vargas, M. H., Segura-Medina, P., Rodríguez-Márquez, A., & Silva, A. V. M. (2021) · Research Square · doi:10.21203/rs.3.rs-287268/v1 · Cited by 1 · see citing works
- Authors
- Su, X., Ren, Y., Li, M., Zhao, X., Kong, L., & Kang, J.
- Affiliations
- First Hospital of China Medical University (CN)
- Corresponding author
- Su, Xinming
- Venue
- Medicine
- Published
- 2016-05
- Volume
- 95
- Issue
- 22
- Pages
- e3459
- ISSN
- 0025-7974 (ISSN-L)
- PMC
- PMC4900697
- OpenAlex
- W2411471160
- Cited by
- 110
- References
- 37
- Citations by year
- 2026: 8 · 2025: 4 · 2024: 14 · 2023: 15 · 2022: 10 · 2021: 15 · 2020: 11 · 2019: 18 · 2018: 10 · 2017: 5
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (2013225049, 81300024)
- Department of Science and Technology of Liaoning Province (2013225049)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
- Keywords
- asthma, comorbidities, cardiovascular comorbidity, obesity, hypertension, diabetes mellitus, psychiatric comorbidity, neurological comorbidity, respiratory comorbidities, cancer, prevalence, chronic disease burden, comorbidity risk factors
- MeSH terms
- Asthma, Cardiovascular Diseases, Cerebrovascular Disorders, Endocrine System Diseases, Humans, Global Health, Comorbidity, Prevalence
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