Sex differences in negative emotional responses to chronic pain
Open accessAbstract
We proposed a sequential model of pain processing with pain intensity as stage 1, pain unpleasantness as stage 2, pain-related emotions (depression, anxiety, frustration, anger, fear) as stage 3, and overt behavioral expression of pain as stage 4. We tested hypotheses about relationships between sex and the first 3 stages of pain processing by conducting simultaneous regression analysis using LISREL-8 with data collected from 967 women and 680 men with chronic pain. We found the following results: (1) women reported higher pain-related frustration and fear; (2) frustration related most highly to pain intensity among women, as compared with anxiety and depression among men; (3) depression and frustration related most highly to usual and highest pain unpleasantness among women, as compared with frustration among men; and (4) contrary to expectations, pain-related emotions were more strongly related to pain for men. Consistent with the sequential model of pain processing, emotional response to pain was more closely related to pain unpleasantness than to pain intensity across sex. Anxiety and frustration were the emotions most highly related to pain. The current results highlight sex differences in the experience of chronic pain and the importance of assessing a range of emotions in patients with pain.
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Response to treatment for chronic pain differs between sexes.
“In addition, response to treatment differs between sexes [6–10].”
From Chronic pain and sex-differences; women accept and move, while men feel blue (2017) · cites this paper as [9]
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Acoustic Measurement of Emotion Expression of Women with Chronic Knee Pain
Rasmussen, S. R. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/mz8g-fj80 · Cited by 1 · see citing works
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Aldolase B and Angiotensinogen are associated with weekly chronic multisite spinal pain in menPreprint
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- Authors
- Riley, J. L., Robinson, M. E., Wade, J. B., Myers, C. D., & Price, D. D.
- Affiliations
- University of Florida Health (US)
- Virginia Commonwealth University (US)
- University of Florida (US)
- Venue
- The Journal of Pain
- Publisher
- Elsevier BV
- Published
- 2001-12
- Volume
- 2
- Issue
- 6
- Pages
- 354-359
- ISSN
- 1526-5900 (ISSN-L)
- OpenAlex
- W2047319884
- Cited by
- 76
- References
- 34
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 5 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 1 · 2019: 5 · 2018: 2 · 2017: 4 · 2015: 2 · 2014: 4 · 2013: 1 · 2012: 2
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Pain (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Pain Management Techniques
- Keywords
- sex differences, chronic pain, pain-related emotions, pain unpleasantness, pain intensity, frustration, fear, anxiety, depression, anger, emotional response to pain
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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