The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.
Biological Roles of Uterine Glands in Pregnancy
Open accessAbstract
All mammalian uteri contain glands in the endometrium that synthesize or transport and secrete substances essential for survival and development of the conceptus (embryo/fetus and associated extraembryonic membranes). This review summarizes information related to the biological roles of uterine glands and their secretions in blastocyst/conceptus survival and implantation, uterine receptivity, and stromal cell decidualization in humans and animal models. The infertility and recurrent pregnancy loss observed in the ovine uterine gland knockout (UGKO) model unequivocally supports a primary role for uterine glands and, by inference, their secretions present in uterine luminal fluid in survival and development of the conceptus. Further, studies with mutant and progesterone-induced UGKO mice found that uterine glands and their secretions are required for establishment of uterine receptivity and blastocyst implantation as well as stromal cell decidualization. Similarly in humans, uterine glands and their secretory products are likely critical regulators of blastocyst implantation, uterine receptivity, and conceptus growth and development during the first trimester. Circumstantial evidence suggests that deficient glandular activity may be a causative factor in pregnancy failure and complications in humans. Thus, an increased understanding of uterine gland biology is important for diagnosis, prevention, and treatment of fertility and pregnancy problems in mammals.
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“There is strong evidence in the sheep and other domestic species that interferon τ performs additional functions, combining with placental lactogens secreted by the trophoblast to upregulate the expression of genes encoding uterine milk proteins and growth factors in the endometrial glands (514).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [514]
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“Complete ablation results in a cessation of growth of the conceptus and loss of the pregnancy in the adult animal, whereas partial ablation leads to a small, non-expanded conceptus that fails to attach.”
From Placental Origins of Chronic Disease (2016) · cites this paper as [514]
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Cites
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Sorted by citations
Pre-eclampsia: pathophysiology and clinical implications
Burton, G. J., Redman, C. W., Roberts, J. M., & Moffett, A. (2019) · BMJ · doi:10.1136/bmj.l2381 · Cited by 1,250
Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium
Turco, M. Y., Gardner, L., Hughes, J., Cindrová‐Davies, T., Gómez‐Ruíz, M., Farrell, L. E., Hollinshead, M. S., Marsh, S. G. E., Brosens, J. J., Critchley, H., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3516 · Cited by 809
Placental Origins of Chronic Disease
Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717
Immune mechanisms at the maternal-fetal interface: perspectives and challenges
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Metadata
- Authors
- Spencer, T.
- Affiliations
- Washington State University (US)
- Corresponding author
- Spencer, Thomas
- ORCID
- Spencer, Thomas
- Venue
- Seminars in Reproductive Medicine
- Publisher
- Georg Thieme Verlag KG
- Published
- 2014-06-24
- Volume
- 32
- Issue
- 05
- Pages
- 346-357
- ISSN
- 1526-4564 (ISSN-L)
- 1526-8004
- PMC
- PMC4198167
- OpenAlex
- W2002782874
- Cited by
- 115
- References
- 7
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 5 · 2023: 13 · 2022: 15 · 2021: 11 · 2020: 10 · 2019: 13 · 2018: 9 · 2017: 9 · 2016: 8 · 2015: 6
- FWCI
- 3.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Seminars in Reproductive Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD076347)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Reproductive Physiology in Livestock
- Keywords
- endometrial glands, endometrial receptivity, embryo implantation, conceptus development, uterine fluid, miscarriage, recurrent pregnancy loss, infertility, progesterone, sheep model, mouse model
- MeSH terms
- Animals, Endometrium, Female, Humans, Embryo Implantation, Pregnancy, Sheep, Uterus, Mice
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