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Cited by 1,250Pregnancy and preeclampsia studiesNeurological Complications and SyndromesReproductive System and Pregnancy

Pre-eclampsia: pathophysiology and clinical implications

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Burton, Graham J, Redman, Christopher W, Roberts, James M, Moffett, Ashley·2019·BMJ
DOI 10.1136/bmj.l2381
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Abstract

Pre-eclampsia is a common disorder that particularly affects first pregnancies. The clinical presentation is highly variable but hypertension and proteinuria are usually seen. These systemic signs arise from soluble factors released from the placenta as a result of a response to stress of syncytiotrophoblast. There are two sub-types: early and late onset pre-eclampsia, with others almost certainly yet to be identified. Early onset pre-eclampsia arises owing to defective placentation, whilst late onset pre-eclampsia may center around interactions between normal senescence of the placenta and a maternal genetic predisposition to cardiovascular and metabolic disease. The causes, placental and maternal, vary among individuals. Recent research has focused on placental-uterine interactions in early pregnancy. The aim now is to translate these findings into new ways to predict, prevent, and treat pre-eclampsia.

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  • Consequently, blood flows at a higher rate towards the villi, probably damaging the terminal branches, causing inflammation and stress later seen in the placenta, and likely playing a role in the development of maternal symptoms seen in hypertensive disorders in pregnancy.

    “Consequently, the blood flows at a higher rate towards the villi, probably damaging the terminal branches, causing the inflammation and stress later seen in the placenta, likely playing a role in the development of the maternal symptoms seen in hypertensive disorders in pregnancy (Burton et al.,”

    From Pregnancy-related maternal physiological adaptations and fetal chemical exposure (2023) · cites this paper as Burton et al., 2019

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Cited by

Sorted by citations

Authors
Burton, G. J., Redman, C. W., Roberts, J. M., & Moffett, A.
Affiliations
  • University of Cambridge (GB)
  • University of Oxford (GB)
  • University of Pittsburgh (US)
Corresponding author
Moffett, Ashley
ORCID
Venue
BMJ
Publisher
BMJ
Published
2019-07-15
Volume
366
Pages
l2381
ISSN
  • 1756-1833 (ISSN-L)
  • 0959-8138
DOI
10.1136/bmj.l2381
OpenAlex
W2960659672
Cited by
1,250
References
12
Citations by year
2026: 136 · 2025: 178 · 2024: 173 · 2023: 231 · 2022: 232 · 2021: 169 · 2020: 121 · 2019: 8
FWCI
20.99
Type
journal article
Language
en
Open access
Licence
www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy (tdm)
Locations
  • BMJ (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
  • Apollo (University of Cambridge) (submittedVersion)
  • Apollo
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Keywords
preeclampsia, pathophysiology, hypertension in pregnancy, proteinuria, syncytiotrophoblast, placental senescence, early-onset preeclampsia, late-onset preeclampsia, cardiovascular disease, metabolic disorders, first pregnancy
MeSH terms
Female, Humans, Placenta, Pre-Eclampsia, Pregnancy, Risk Factors, Trophoblasts, Uterus, Age of Onset

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