Cited by 35Endometriosis Research and TreatmentGynecological conditions and treatmentsIntestinal and Peritoneal Adhesions

Evaluation of cases of abdominal wall endometriosis at Universidade Estadual de Campinas in a period of 10 Years

Open access
Yela, Daniela Angerame, Trigo, Lucas, Benetti-Pinto, Cristina Laguna·2017·Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics

Abstract

Purpose To determine the clinical and epidemiological characteristics of abdominal wall endometriosis (AWE), as well as the rate and recurrence factors for the disease. Methods A retrospective study of 52 women with AWE was performed at Universidade Estadual de Campinas from 2004 to 2014. Of the 231 surgeries performed for the diagnosis of endometriosis, 52 women were found to have abdominal wall endometriosis (AWE). The frequencies, means and standard deviations of the clinical characteristics of these women were calculated, as well as the recurrence rate of AWE. To determine the risk factors for disease recurrence, Fisher's exact test was used. Results The mean age of the patients was 30.71 ± 5.91 years. The main clinical manifestations were pain (98%) and sensation of a mass (36.5%). We observed that 94% of these women had undergone at least 1 cesarean section, and 73% had used medication for the postoperative control of endometriosis. The lesion was most commonly located in the cesarean section scar (65%). The recurrence rate of the disease was of 26.9%. All 14 women who had relapsed had surgical margins compromised in the previous surgery. There was no correlation between recurrent AWE and a previous cesarean section (p = 0.18), previous laparotomy (p = 0.11), previous laparoscopy (p = 0.12) and postoperative hormone therapy (p = 0.51). Conclusion Women with previous cesarean sections with local pain or lumps should be investigated for AWE. The recurrence of AWE is high, especially when the first surgery is not appropriate and leaves compromised surgical margins.

AI snapshot

Written from the paper’s full text.

TL;DR

This retrospective study of 52 women with abdominal wall endometriosis at Universidade Estadual de Campinas (2004–2014) found pain and a mass as the main symptoms, mostly in cesarean-section scars, with a 26.9% recurrence rate. All 14 recurrences had compromised surgical margins in the previous surgery, though no significant correlation was found with prior cesarean, laparotomy, laparoscopy, or postoperative hormone therapy.

Key findings

  • Mean age was 30.71 ± 5.91 years; mean BMI was 26.48 ± 5.24 kg/m²; main manifestations were nodule pain (98%) and sensation of a mass (36.5%); mean symptom duration was 39.83 ± 34.09 months.
  • 94% had undergone at least 1 cesarean section; the lesion was most commonly located in the cesarean section scar (65.4%); mean lesion size was 2.52 ± 1.21 cm on ultrasound and 3.98 ± 1.72 cm intraoperatively.
  • The recurrence rate was 26.9%; all 14 women who relapsed had compromised surgical margins in the previous surgery.
  • No correlation was found between recurrent AWE and previous cesarean section (p = 0.18), previous laparotomy (p = 0.11), previous laparoscopy (p = 0.12), or postoperative hormone therapy (p = 0.51).

Methods

  • Retrospective study at Universidade Estadual de Campinas from January 2004 to December 2014; 917 surgeries were assessed, 231 were selected for endometriosis removal, 56 AWE cases were identified, and 4 were excluded for insufficient chart data or lack of histopathological confirmation, leaving 52 women for analysis.
  • Variables analyzed included age, pregnancies, parity, cesarean section, abortion, BMI, symptoms (pelvic pain, mass, bleeding), symptom duration, associated diseases, postsurgical menstrual-suppression medication, and size and location of the endometrioma.
  • Frequencies, means, and standard deviations were calculated; Fisher’s exact test was used to determine recurrence factors; SAS version 9.4 was used. The study was approved by the institutional Research Ethics Committee under number 342430/2013.

Limitations

  • The paper states that its retrospective nature made data collection and complete data acquisition more difficult, and suggests a prospective study.
  • The text makes evident that the study was single-center at a tertiary hospital, with 52 women and only 14 recurrence cases, limiting generalizability and statistical power for recurrence-factor analysis.
  • The text makes evident that recurrence-factor analysis used Fisher’s exact test without multivariable adjustment; no further limitations are stated in the paper.

Model-written summary. Check it against the paper before relying on it.

Integrity signals

Registry

Crossref · 10.1055/s-0037-1603965

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Nothing to recompute.

Claims the paper makes

0 of 21 cited sources checked · 0 supported · 0 flagged

  • Findingown data

    The precise relationship between cesarean section and abdominal wall endometriosis could not be established in this study.

    “In the present study, the precise relationship between cesarean section and AWE could not be established, despite the high rate of cesarean sections in patients with AWE.”
    Quote in the paperSubstantial claim
  • Findingown data

    There was no correlation between recurrent abdominal wall endometriosis and postoperative hormone therapy (p = 0.51).

    “There was no correlation between recurrent AWE and a previous cesarean section (p = 0.18), previous laparotomy (p = 0.11), previous laparoscopy (p = 0.12) and postoperative hormone therapy (p = 0.51).”
    Quote in the paperSubstantial claim
  • Findingown data

    The mean age of the 52 women with abdominal wall endometriosis was 30.71 ± 5.91 years.

    “The mean age of the women was 30.71 ± 5.91 years.”
    Quote in the paperNot a substantial claim
  • Findingown data

    Sensation of a mass was a clinical manifestation in 36.5% of the women with abdominal wall endometriosis.

    “The main clinical manifestations were nodule pain (98%) and the sensation of a mass (36.5%).”
    Quote in the paperNot a substantial claim
  • Findingown data

    There was no correlation between recurrent abdominal wall endometriosis and previous laparoscopy (p = 0.12).

    “There was no correlation between recurrent AWE and a previous cesarean section (p = 0.18), previous laparotomy (p = 0.11), previous laparoscopy (p = 0.12) and postoperative hormone therapy (p = 0.51).”
    Quote in the paperSubstantial claim
  • Classified as probably not a substantial claim. 14
  • The quote only partly states this claim. 3
  • May combine two claims. 5
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingown data

    The mean body mass index of the women with abdominal wall endometriosis was 26.48 ± 5.24 kg/m2.

    “The mean BMI was 26.48 ± 5.24 kg/m2”
    Quote in the paperNot a substantial claim
  • The quote only partly states this claim.

    Findingown data

    The mean size of the endometrioma on ultrasound was 2.52 ± 1.21 cm.

    “the mean size of the lesion was 2.52 ± 1.21 cm on ultrasound, and 3.98 ± 1.72 cm in the intraoperative period”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingown data

    Only one woman had a painless mass.

    “Only one woman had a painless mass”
    Quote in the paperNot a substantial claim
  • The quote only partly states this claim.

    Findingown data

    The mean size of the endometrioma in surgery was 3.98 ± 1.72 cm.

    “the mean size of the lesion was 2.52 ± 1.21 cm on ultrasound, and 3.98 ± 1.72 cm in the intraoperative period”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S1 (asserted), S3 (load-bearing), S4 (based). The quote only partly states this claim.

    Findingown data

    The mean duration of clinical manifestations was 39.83 ± 34.09 months.

    “The mean duration of the clinical treatment was 39.83 ± 34.09 months.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    Endometriosis is characterized by the presence of endometrial tissue with glands and stroma implanted outside the uterine cavity, which responds to ovarian hormone stimulation.

    “Endometriosis is a disease characterized by the presence of endometrial tissue with glands and stroma implanted outside the uterine cavity, which responds to ovarian hormone stimulation.”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites [1] L C Giudice, 2004, Endometriosis, Lancet source

      Not checked in the free run.

    • cites [2] H Bektaş, 2010, Abdominal wall endometrioma; a 10-year experience and brief review of the literature, J Surg Res source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    Extrapelvic endometriosis occurs in 9-15% of endometriosis cases.

    “The disease is less commonly (9–15%) located outside the pelvic cavity, and is termed extrapelvic endometriosis.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [3] C Douglas, 2004, Extragenital endometriosis--a clinicopathological review of a Glasgow hospital experience with case illustrations, J Obstet Gynaecol source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisecitation

    The incidence of abdominal wall endometriosis is rare, occurring in 0.03-3.5% of cases, with some studies reporting up to 12%.

    “The incidence of abdominal wall endometriosis (AWE) is rare. The disorder occurs in 0.03–3.5% of cases, and some studies have reported a rate of up to 12%.”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites [12] N S Nominato, 2010, Caesarean section greatly increases risk of scar endometriosis, Eur J Obstet Gynecol Reprod Biol source

      Not checked in the free run.

    • cites [15] Y Chang, 2009, Abdominal wall endometriomas, J Reprod Med

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductreasoning

    A limitation of the study is its retrospective nature, which makes data collection and complete data acquisition more difficult.

    “A limitation of the study is its retrospective nature, which makes data collection and complete data acquisition more difficult.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisecitation

    Endometriosis affects women of reproductive age and is more common in multiparous women aged 25 to 35 years.

    “According to the literature, endometriosis affects women of reproductive age. It is more common in multiparous women aged 25 to 35 years.25”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [25] X Zhao, 2005, Abdominal wall endometriomas, Int J Gynaecol Obstet source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    Other therapeutic options for abdominal wall endometriosis are suppression of menstruation with progestins or a gonadotropin-releasing hormone (GnRH) analogue.

    “Other therapeutic options are the suppression of menstruation with progestins or a gonadotropin-releasing hormone (GnRH) analogue.20”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [20] G KC Leite, 2009, Scar endometrioma following obstetric surgical incisions: retrospective study on 33 cases and review of the literature, Sao Paulo Med J source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    Abdominal wall endometriosis mostly affects patients with a history of cesarean section.

    “The disease mostly affects patients with a history of cesarean section.17”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [17] T Wasfie, 2002, Abdominal wall endometrioma after cesarean section: a preventable complication, Int Surg

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisecitation

    Alcohol consumption and heavy menstrual bleeding may be risk factors for abdominal wall endometriosis, while multiparity may be a protective factor.

    “A study indicated that alcohol consumption and heavy menstrual bleeding may be risk factors for the development of AWE. In contrast, multiparity may be a protective factor.27”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [27] M A de Oliveira, 2007, Risk factors for abdominal scar endometriosis after obstetric hysterotomies: a case-control study, Acta Obstet Gynecol Scand source

      Not checked in the free run.

  • Classified as probably not a substantial claim.

    Premisecitation

    To prevent recurrence of abdominal wall endometriosis, surgical resection with free margins should be performed.

    “To prevent this occurrence, surgical resection with free margins should be performed.20 21 22 23”
    Quote in the paperSubstantial claim0 of 3 sources checked
    • cites [20] G KC Leite, 2009, Scar endometrioma following obstetric surgical incisions: retrospective study on 33 cases and review of the literature, Sao Paulo Med J source

      Not checked in the free run.

    • cites [21] Y Ding, 2013, A retrospective review of abdominal wall endometriosis in Shanghai, China, Int J Gynaecol Obstet source

      Not checked in the free run.

    • cites [22] F L Vilarino, 2011, [Surgical scar endometriosis: a series of 42 patients], Rev Bras Ginecol Obstet

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisecitation

    Abdominal wall endometriosis is associated with a history of obstetric or gynecologic procedures, although some cases occur spontaneously.

    “It is associated with a history of obstetric or gynecologic procedures,2 12 although some cases occur spontaneously.16”
    Quote in the paperNot a substantial claim0 of 3 sources checked
    • cites [2] H Bektaş, 2010, Abdominal wall endometrioma; a 10-year experience and brief review of the literature, J Surg Res source

      Not checked in the free run.

    • cites [12] N S Nominato, 2010, Caesarean section greatly increases risk of scar endometriosis, Eur J Obstet Gynecol Reprod Biol source

      Not checked in the free run.

    • cites [16] T S Papavramidis, 2009, Spontaneous abdominal wall endometriosis: a case report, Acta Chir Belg source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisecitation

    The preferential treatment for abdominal wall endometriosis is surgery, and the diagnosis is confirmed by histopathology.

    “The preferential treatment is surgery, and the diagnosis is confirmed by histopathology.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [20] G KC Leite, 2009, Scar endometrioma following obstetric surgical incisions: retrospective study on 33 cases and review of the literature, Sao Paulo Med J source

      Not checked in the free run.

16 of 16

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

Each contradiction between two passages listed here was confirmed by an independent check.

  • Age standard deviation differs between results and Table 1

    Minor

    The results give the age standard deviation as 5.91 years, while Table 1 gives 5.92 years.

  • Laparotomy percentage does not match its count

    Minor

    Table 3 reports 5 of 14 patients in the laparotomy "Yes" category as 25.19%; 5 divided by 14 is approximately 35.71%.

    Reported 25.19 · recomputed 35.714286

  • Cesarean-section history reported as both 51% and 94%

    Minor

    The discussion says that only 51% of patients in this study had a cesarean delivery, whereas the results report 94%. The discrepancy affects a characteristic emphasized in the conclusion.

3 of 3

Cites

Flagged first, then by citations

2 of the 32 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. N S Nominato, 2007, [Scar endometriosis: a retrospective study of 72 patients], Rev Bras Ginecol Obstet, 29, 423

Cited by

Sorted by citations

Authors
Yela, D. A., Trigo, L., & Benetti-Pinto, C. L.
Affiliations
  • Universidade Estadual de Campinas (UNICAMP) (BR)
  • Department of Obstetrics and Gynecology, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (Unicamp), Campinas, São Paulo, Brazil
Venue
Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics
Published
2017-06-21
Volume
39
Issue
08
Pages
403-407
ISSN
  • 0100-7203 (ISSN-L)
  • 1806-9339
OpenAlex
W2665280447
Cited by
35
References
32
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 22 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 1
FWCI
2.22
Type
journal article
Language
en
Open access
Locations
  • Revista Brasileira Ginecologia e Obstetrícia (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
  • Americanae (AECID Library) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
  • Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
Keywords
abdominal wall endometriosis, endometriosis recurrence, cesarean section scar, surgical margins, recurrence risk factors, postoperative pain, postoperative hormone therapy, laparotomy, laparoscopy, clinical features
MeSH terms
Adult, Brazil, Endometriosis, Female, Humans, Muscular Diseases, Recurrence, Retrospective Studies, Time Factors, Universities, Abdominal Wall

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