Cited by 196Ovarian function and disordersEndometriosis Research and TreatmentReproductive Biology and Fertility

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A Summary on Polycystic Ovary Syndrome: Diagnostic Criteria, Prevalence, Clinical Manifestations, and Management According to the Latest International Guidelines

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Neven, Adriana, Laven, Joop, Teede, Helena, Boyle, Jacqueline·2018·Seminars in Reproductive Medicine

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Abstract

Polycystic ovary syndrome (PCOS) is a common hormonal condition with reproductive, metabolic, and psychological sequelae. The Rotterdam Criteria are now internationally accepted, with different phenotypes recognized with varying clinical presentations and risk profiles. The complexity of the disorder, and the impact on quality of life, requires timely diagnosis, screening for complications and management strategies. PCOS remains underdiagnosed and women experience significant delays to diagnosis. Effective dissemination of evidence-based management is therefore vital. In this review, we summarize key aspects of PCOS as a prelude to this issue of Seminars in Reproductive Medicine on PCOS which focuses on the development of the international evidence-based guideline on the assessment and management of PCOS and the related translation program. We cover diagnostic criteria, prevalence, phenotypes, reproductive, metabolic, and psychological factors of PCOS. We also cover management strategies including lifestyle interventions as well as treatment of nonreproductive outcomes and reproductive outcomes informed by the latest international evidence-based guidelines.

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Pestrikova, T. Y., Yurasova, E. A., Kovaleva, T., Shcherbakova, O., Enginoeva, T. A., & Yurasova, T. I. (2024) · Vrach · doi:10.29296/25877305-2023-04-06
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冀, 凡. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.1461868
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Additional file 1 of High levels of fatty acid-binding protein 5 excessively enhances fatty acid synthesis and proliferation of granulosa cells in polycystic ovary syndrome
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Additional file 2 of Periodontal and systemic health of morbidly obese patients eligible for bariatric surgery: a cross-sectional study
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Additional file 1 of What can be done to improve polycystic ovary syndrome (PCOS) healthcare? Insights from semi-structured interviews with women in Canada
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Additional file 2 of What can be done to improve polycystic ovary syndrome (PCOS) healthcare? Insights from semi-structured interviews with women in Canada
Ismayilova, M., & Yaya, S. (2022) · Figshare · doi:10.6084/m9.figshare.19745310
Additional file 2 of High levels of fatty acid-binding protein 5 excessively enhances fatty acid synthesis and proliferation of granulosa cells in polycystic ovary syndrome
Liu, J., Li, J., Wu, X., Zhang, M., Yan, G., Sun, H., & Li, D. (2024) · Figshare · doi:10.6084/m9.figshare.25248940
Additional file 1 of Periodontal and systemic health of morbidly obese patients eligible for bariatric surgery: a cross-sectional study
Čolak, D., Cmok Kučič, A., Pintar, T., Gašpirc, B., & Gašperšič, R. (2022) · Figshare · doi:10.6084/m9.figshare.19766277
Additional file 1 of LncRNA SNHG12 promotes cell proliferation and inhibits apoptosis of granulosa cells in polycystic ovarian syndrome by sponging miR-129 and miR-125b
Xuan, F., Jin, R., Zhou, W., Ye, Y., Ren, Y., Lu, J., & Chen, A. (2024) · Figshare · doi:10.6084/m9.figshare.25530315
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Cicero, A. F. G., Scapagnini, G., Grassi, D., Marazzi, G., Zanchè, A., Genazzani, A. D., Scairati, R., & Colao, A. (2026) · Nutrients · doi:10.3390/nu18050868
Polycystic ovarian syndrome and infertility
Sharma, R., Nivedita, Kumar, S., Lalhlenmawia, H., Verma, N., Shavkatjonazizov, & Kumar, D. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-43986-5.00039-4
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Costa, L. O. B. F., & Soares, G. M. (2021) · Femina · doi:10.61622/0100-7254499202102
Impaired adipogenesis and lipid storage capacity in subcutaneous adipose tissue of patients with PMOS
Divoux, A., Erdős, E., Whytock, K. L., Osborne, T. F., & Smith, S. R. (2026) · JCI Insight · doi:10.1172/jci.insight.199981
Модели программирования исходов экстракорпорального оплодотворения у женщин с синдромом поликистозных яичников
Агабабян, Л. Р., & Усмонкулова, Х. М. (2026) · Репродуктивное здоровье Восточная Европа · doi:10.34883/pi.2026.16.4.006
Associations among quality of life, depressive symptoms, body shape concerns, anthropometric characteristics, and diet quality in women with PMOS: a cross-sectional study
Irmak, E., & Şanlıer, N. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1928327

Authors: Neven, A., Laven, J., Teede, H., & Boyle, J.
Affiliations: Erasmus MC (NL)
Monash University (AU)
Monash Medical Centre (AU)
Corresponding author: Boyle, Jacqueline
ORCID: Neven, Adriana
Laven, Joop
Teede, Helena
Boyle, Jacqueline
Venue: Seminars in Reproductive Medicine
Publisher: Georg Thieme Verlag KG
Published: 2018-01
Volume: 36
Issue: 01
Pages: 005-012
ISSN: 1526-4564 (ISSN-L)
1526-8004
DOI: 10.1055/s-0038-1668085
OpenAlex: W2891202838
Cited by: 196
References: 83
Citations by year: 2026: 9 · 2025: 22 · 2024: 29 · 2023: 32 · 2022: 43 · 2021: 35 · 2020: 18 · 2019: 8
FWCI: 2.30
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Seminars in Reproductive Medicine (publishedVersion)
PubMed (publishedVersion)
Monash University Research Portal (Monash University) (submittedVersion, other-oa)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Funders: National Health and Medical Research Council
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Keywords: polycystic ovary syndrome, Rotterdam criteria, PCOS phenotypes, prevalence, delayed diagnosis, reproductive outcomes, metabolic complications, psychological factors, lifestyle intervention, PCOS management, evidence-based recommendations, quality of life
MeSH terms: Female, Humans, Infertility, Female, Life Style, Polycystic Ovary Syndrome, Prevalence, Symptom Assessment

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A Summary on Polycystic Ovary Syndrome: Diagnostic Criteria, Prevalence, Clinical Manifestations, and Management According to the Latest International Guidelines

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