The DOI matches its Crossref record.
Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Pharmacokinetic studies in cancer patients and healthy volunteers have shown that at doses of 8 g per day of pure curcumin (99.3%), 3.6 g of curcuminoids, or piperine (20 mg) co-administered with 2 g of curcumin, the highest mean maximum plasma concentration (Cmax) was 1.77 ± 1.87 μM (Shoba et al., 1998; Cheng et al., 2001; Sharma et al., 2004).”
From Curcuminoids Inhibit Multiple Human Cytochromes P450, UDP-Glucuronosyltransferase, and Sulfotransferase Enzymes, whereas Piperine Is a Relatively Selective CYP3A4 Inhibitor (2008) · cites this paper as Shoba et al., 1998
In the citing paper
“Piperine, found in the extract of black pepper, enhances the relative oral bioavailability of curcuminoids by as much as 20-fold in healthy human volunteers (Shoba et al., 1998).”
From Curcuminoids Inhibit Multiple Human Cytochromes P450, UDP-Glucuronosyltransferase, and Sulfotransferase Enzymes, whereas Piperine Is a Relatively Selective CYP3A4 Inhibitor (2008) · cites this paper as Shoba et al., 1998
In the citing paper
“Additionally, 20 mg of pure piperine increased the serum AUC0–3h of curcumin by 20-fold relative to curcumin taken without piperine [5].”
From Predicting Food–Drug Interactions between Piperine and CYP3A4 Substrate Drugs Using PBPK Modeling (2024) · cites this paper as [5]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Bioavailability of curcumin: Problems and promises
Anand, P., Kunnumakkara, A. B., Newman, R. A., & Aggarwal, B. B. (2007) · Molecular Pharmaceutics · doi:10.1021/mp700113r · Cited by 5,543
Curcumin: A Review of Its Effects on Human Health
Hewlings, S., & Kalman, D. (2017) · Foods · doi:10.3390/foods6100092 · Cited by 2,720
I NHIBITION OF C ARCINOGENESIS BY D IETARY P OLYPHENOLIC C OMPOUNDS
Yang, C. S., Landau, J. M., Huang, M.-T., & Newmark, H. L. (2001) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.21.1.381 · Cited by 1,260
Aggarwal, B. B., & Sung, B. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.11.002 · Cited by 1,140
Black Pepper and its Pungent Principle-Piperine: A Review of Diverse Physiological Effects
Srinivasan, K. (2007) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390601062054 · Cited by 821
Madeo, F., Carmona-Gutierrez, D., Hofer, S. J., & Kroemer, G. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.018 · Cited by 630
The effect of curcumin (turmeric) on Alzheimer’s disease: An overview
Mishra, S., & Palanivelu, K. (2008) · Annals of Indian Academy of Neurology · doi:10.4103/0972-2327.40220 · Cited by 599
Piperine: A review of its biological effects
Haq, I., Imran, M., Nadeem, M., Tufail, T., Gondal, T. A., & Mubarak, M. S. (2021) · Phytotherapy Research · doi:10.1002/ptr.6855 · Cited by 434
Polyphenols and Their Impact on the Prevention of Neurodegenerative Diseases and Development
Grabska-Kobyłecka, I., Szpakowski, P., Król, A., Książek-Winiarek, D., Kobyłecki, A., Głąbiński, A., & Nowak, D. (2023) · Nutrients · doi:10.3390/nu15153454 · Cited by 273
Bioavailability challenges associated with development of anti-cancer phenolics
Gao, S., & Hu, M. (2010) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955710791384081 · Cited by 242
Haroyan, A., Mukuchyan, V., Mkrtchyan, N., Minasyan, N., Gasparyan, S., Sargsyan, A., Narimanyan, M., & Hovhannisyan, A. (2018) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-017-2062-z · Cited by 232
Kakkar, V., Muppu, S. K., Chopra, K., & Kaur, I. P. (2013) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2013.02.005 · Cited by 222
Neurotherapeutic applications of nanoparticles in Alzheimer’s disease
Sahni, J. K., Doggui, S., Ali, J., Baboota, S., Dao, L., & Ramassamy, C. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.11.033 · Cited by 219
Volak, L. P., Ghirmai, S., Cashman, J. R., & Court, M. H. (2008) · Drug Metabolism and Disposition · doi:10.1124/dmd.108.020552 · Cited by 214
Stefanska, B., Karlic, H., Varga, F., Fabianowska‐Majewska, K., & Haslberger, A. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02002.x · Cited by 200
Overview of metabolism and bioavailability enhancement of polyphenols
Lewandowska, U., Szewczyk, K., Hrabec, E., Janecka, A., & Gorlach, S. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf404439b · Cited by 196
Clinical development of curcumin in neurodegenerative disease
Hu, S., Maiti, P., Ma, Q., Zuo, X., Jones, M. R., Cole, G. M., & Frautschy, S. A. (2015) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2015.1044981 · Cited by 179
Gurley, B., Fifer, E., & Gardner, Z. (2012) · Planta Medica · doi:10.1055/s-0031-1298331 · Cited by 165
Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer’s disease
Ahmed, T., Enam, S. A., & Gilani, A. H. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.05.078 · Cited by 156
Hasan, M., Elkhoury, K., Kahn, C. J. F., Arab-Tehrany, E., & Linder, M. (2019) · Molecules · doi:10.3390/molecules24102023 · Cited by 133
Parachikova, A., Green, K. N., Hendrix, C., & LaFerla, F. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014015 · Cited by 87
Kenđel Jovanović, G., Mrakovcic-Sutic, I., Pavičić Žeželj, S., Šuša, B., Rahelić, D., & Klobučar Majanović, S. (2020) · Nutrients · doi:10.3390/nu12113583 · Cited by 73
The Positive Role of Curcumin-Loaded Salmon Nanoliposomes on the Culture of Primary Cortical Neurons
Hasan, M., Latifi, S., Kahn, C. J. F., Tamayol, A., Habibey, R., Passeri, E., Linder, M., & Arab-Tehrany, E. (2018) · Marine Drugs · doi:10.3390/md16070218 · Cited by 54
Possible role of common spices as a preventive and therapeutic agent for Alzheimer's disease
Mirmosayyeb, O., Tanhaei, A., Sohrabi, H. R., Martins, R. N., Tanhaei, M., Najafi, M. A., Safaei, A., & Meamar, R. (2017) · International Journal of Preventive Medicine · doi:10.4103/2008-7802.199640 · Cited by 50
Encapsulation of curcumin in alginate microbeads(AMB) for control release of curcumin
Shaikh, S. A. M., & Barik, A. (2023) · Journal of Chemical Sciences · doi:10.1007/s12039-023-02159-0 · Cited by 21
Predicting Food–Drug Interactions between Piperine and CYP3A4 Substrate Drugs Using PBPK Modeling
Lin, F., Hu, Y., Zhang, Y., Zhao, L., Zhong, D., & Liu, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252010955 · Cited by 20
Metadata
- Authors
- Shoba, G., Joy, D., Joseph, T., Majeed, M., Rajendran, R., & Srinivas, P.
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 1998-05
- Volume
- 64
- Issue
- 04
- Pages
- 353-356
- ISSN
- 0032-0943
- 1439-0221
- Cited by
- 1,656
- References
- 0
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
