The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Hepatocyte Transplantation for the Treatment of Human Disease
Abstract
A great deal of work with animal models indicates that hepatocytes transplanted into the liver or spleen survive, function, and participate in the normal regenerative process. Recent clinical studies suggest that hepatocyte transplantation may be useful for bridging patients to whole organ transplantation and for providing metabolic support during liver failure and for replacing whole organ transplantation in certain metabolic liver diseases. In specific situations where the rate of death of host hepatocytes is high, the transplanted cells can repopulate the native liver. Techniques have been established for the large scale isolation, culture and cryopreservation of human hepatocytes. Shortage of donor organs and the need for immunosuppression are two major hurdles to widespread application of this procedure, and current research in experimental animals is aimed at addressing these problems.
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Cites
Treatment of the Crigler–Najjar Syndrome Type I with Hepatocyte Transplantation
Fox, I. J., Chowdhury, J. R., Kaufman, S. S., Goertzen, T. C., Chowdhury, N. R., Warkentin, P. I., Dorko, K., Sauter, B. V., & Strom, S. C. (1998) · New England Journal of Medicine · doi:10.1056/nejm199805143382004 · Cited by 1,023
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HEPATOCYTE TRANSPLANTATION AS A BRIDGE TO ORTHOTOPIC LIVER TRANSPLANTATION IN TERMINAL LIVER FAILURE
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Self-citation
Cited by
Tissue Engineering--Current Challenges and Expanding Opportunities
Griffith, L. G., & Naughton, G. (2002) · Science · doi:10.1126/science.1069210 · Cited by 2,343
Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
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Generation of Hepatocyte-Like Cells from Human Embryonic Stem Cells
Rambhatla, L., Chiu, C.-P., Kundu, P., Peng, Y., & Carpenter, M. K. (2003) · Cell Transplantation · doi:10.3727/000000003783985179 · Cited by 437
Zhou, J., Zhai, Y., Mu, Y., Gong, H., Uppal, H., Toma, D., Ren, S., Evans, R. M., & Xie, W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511116200 · Cited by 368
Human hepatocyte transplantation: current experience and future challenges
Dhawan, A., Puppi, J., Hughes, R. D., & Mitry, R. R. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.44 · Cited by 362
Metadata
- Authors
- Strom, S., Chowdhury, J., & Fox, I.
- Venue
- Seminars in Liver Disease
- Publisher
- Georg Thieme Verlag KG
- Published
- 1999
- Volume
- 19
- Issue
- 01
- Pages
- 39-48
- ISSN
- 0272-8087 (ISSN-L)
- 1098-8971
- OpenAlex
- W2070991874
- Cited by
- 366
- References
- 47
- FWCI
- 10.64
- Type
- journal article
- Language
- en
- Open access
- closed
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