The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Exercise-Induced Muscle Damage
Abstract
Muscular overuse is associated with structural damage of the contractile elements and reflected in delayed onset muscle soreness (DOMS). Mechanical stress is supposed to be the major contributing factor for inducing muscle damage. The initial damage is followed by an inflammatory response and eventually by regeneration. Calcium is assumed to play an important role in triggering the inflammatory changes. Biopsy data in man indicate that the inflammatory changes in humans do not parallel the soreness ratings, leaving the delayed onset of muscle soreness unexplained. It is a well known phenomenon that one bout of eccentric exercise has a long lasting protective effect against damage induced by a second bout of exercise. Experimental evidence suggests that this adaptation can partly be attributed to an increase in connective tissue. Plasma CK activity has widely been used as a marker for the amount of muscle damage. It has been shown that gender differences in exercise-induced CK release are caused by sex hormones dependent differences in sarcolemmal permeability. Plasma CK activity does not necessarily reflect the amount of structural damage.
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“These effects are particularly relevant for athletes undergoing unaccustomed or eccentric exercise, which induces exercise-induced muscle damage (EIMD), inflammation, and oxidative stress [74,82].”
From Use of Nutritional Strategies, Bioactive Compounds, and Dietary Supplements in Young Athletes: From Evidence to Potential Risks—A Narrative Review (2025) · cites this paper as [74]
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Citations
Cites
Myofibrillar damage following intense eccentric exercise in man
Fridén, J., Sjöström, M., & Ekblom, B. (1983) · International Journal of Sports Medicine · doi:10.1055/s-2008-1026030 · Cited by 1,005
Muscle function after exercise-induced muscle damage and rapid adaptation
CLARKSON, P. M., NOSAKA, K., & BRAUN, B. (1992) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199205000-00004 · Cited by 970
Initial events in exercise-induced muscular injury
BEN KIBLER, C. W., & ARMSTRONG, R. B. (1990) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199008000-00002 · Cited by 457
Cited by
Muscle damage is linked to cytokine changes following a 160-km race
Nieman, D. C., Dumke, C. L., Henson, D. A., McAnulty, S. R., Gross, S. J., & Lind, R. H. (2005) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2005.03.008 · Cited by 180
Modulation of autophagy and ubiquitin-proteasome pathways during ultra-endurance running
Jamart, C., Francaux, M., Millet, G. Y., Deldicque, L., Frère, D., & Féasson, L. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00952.2011 · Cited by 157
Shin, K.-A., Park, K. D., Ahn, J., Park, Y., & Kim, Y.-J. (2016) · Medicine · doi:10.1097/md.0000000000003657 · Cited by 109
“Marathon running induces not only musculoskeletal injury but also atraumatic, temporary dysfunction and injury to the cardiovascular system, liver, and kidney.(3,4,6,7,9) Increases in AST, ALT, and LDH after a 24-hour ultramarathon indicate chronic liver injury because of long-time extreme exercise.”
BackgroundJamurtas, A. Z., Koutedakis, Y., Paschalis, V., Tofas, T., Yfanti, C., Tsiokanos, A., Koukoulis, G., Kouretas, D., & Loupos, D. (2004) · European Journal of Applied Physiology · doi:10.1007/s00421-004-1156-8 · Cited by 81
Comparison of lower limb muscle activation during downhill, level and uphill running
Cai, Z.-Y., Hsu, C.-C., Su, C.-P., Lin, C.-F., Lin, Y.-A., Lin, C.-L., & Hsu, M.-C. (2010) · Isokinetics and Exercise Science · doi:10.3233/ies-2010-0379 · Cited by 22
de Souza, R. F., Augusto, R. L., de Moraes, S. R. A., de Souza, F. B., Gonçalves, L. V. D. P., Pereira, D. D., Moreno, G. M. M., de Souza, F. M. A., & Andrade-da-Costa, B. L. D. S. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00157 · Cited by 16
(2018) · Europe PMC (PubMed Central) · Cited by 16
De Zan, D., Eletti, F., Fiore, G., Di Girolamo, E., Bozzini, G. G. M., Perico, V., Tosi, M., Norsa, L., Zuccotti, G., & Verduci, E. (2025) · Nutrients · doi:10.3390/nu17132194 · Cited by 11
Metadata
- Authors
- Kuipers, H.
- Venue
- International Journal of Sports Medicine
- Publisher
- Georg Thieme Verlag KG
- Published
- 1994-04
- Volume
- 15
- Issue
- 03
- Pages
- 132-135
- ISSN
- 0172-4622 (ISSN-L)
- 1439-3964
- OpenAlex
- W2089175192
- Cited by
- 255
- References
- 3
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
