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Formation of Artemisinin in Artemisia annua During One Vegetation Period*,1
Abstract
In order to investigate the possibility of isolating greater amounts of the antimalarial compound artemisinin (quinghaosu), plants of ARTEMISIA ANNUA were cultivated and analysed at different stages of development. We found the highest content just before flowering. It was also possible to correlate development of the plants with the maximum content of artemisinin. ARTEMISIA ANNUA plants cultivated from various other sources were also examine for artemisinin content. According to our results, none of these plants contained sufficient amounts of artemisinin to justify an isolation on a technical scale. Furthermore other Artemisia species were tested. We found artemisinin in only one other species. To possibly increase the amount of artemisinin during the growth period of the plant, we tested two hormone-type growth regulators on A. ANNUA strain 811. The results showed that one of them, chlormequat, was able to increase the artemisinin content by 30% over untreated plants. We also found some slight effects of the growth regulators on morphological criteria of glandular trichomes.
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“There is increasing evidence that artemisinin production in A. annua is localized in the biseriate glandular trichomes: specialized structures, found predominantly on the surface of leaves and flowers [244,325].”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [325]
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Ferreira, J., Luthria, D. L., Sasaki, T., & Heyerick, A. (2010) · Molecules · doi:10.3390/molecules15053135 · Cited by 532
The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)
Brown, G. D. (2010) · Molecules · doi:10.3390/molecules15117603 · Cited by 363
Duke, M. V., Paul, R. N., Elsohly, H. N., Sturtz, G., & Duke, S. O. (1994) · International Journal of Plant Sciences · doi:10.1086/297173 · Cited by 252
Matías‐Hernández, L., Jiang, W., Yang, K., Tang, K., Brodelius, P. E., & Pelaz, S. (2017) · The Plant Journal · doi:10.1111/tpj.13509 · Cited by 220
Effects of components of Artemisia annua on coccidia infections in chickens
Allen, P. C., Lydon, J., & Danforth, H. D. (1997) · Poultry Science · doi:10.1093/ps/76.8.1156 · Cited by 199
“Extracts were filtered, dried under vacuum, and stored at –10 C until analyzed following methods of Zhao and Zeng (1985) and Liersch et al. (1986).”
BackgroundMethodInfluential
Metadata
- Authors
- Liersch, R., Soicke, H., Stehr, C., & Tüllner, H.-U.
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 1986-10
- Volume
- 52
- Issue
- 05
- Pages
- 387-390
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W2073095771
- Cited by
- 107
- References
- 0
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 8 · 2014: 2 · 2013: 4 · 2012: 8
- FWCI
- 0.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Planta Medica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant tissue culture and regeneration
- Keywords
- artemisinin, Artemisia annua, antimalarial compounds, plant growth stages, flowering, plant development, artemisinin content, chlormequat chloride, plant growth regulators, glandular trichomes
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