Cited by 107Plant biochemistry and biosynthesisSesquiterpenes and Asteraceae StudiesPlant tissue culture and regeneration

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Formation of Artemisinin in Artemisia annua During One Vegetation Period*,1

Liersch, R., Soicke, H., Stehr, C., Tüllner, H.-U.·1986·Planta Medica

DOI 10.1055/s-2007-969193

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Abstract

In order to investigate the possibility of isolating greater amounts of the antimalarial compound artemisinin (quinghaosu), plants of ARTEMISIA ANNUA were cultivated and analysed at different stages of development. We found the highest content just before flowering. It was also possible to correlate development of the plants with the maximum content of artemisinin. ARTEMISIA ANNUA plants cultivated from various other sources were also examine for artemisinin content. According to our results, none of these plants contained sufficient amounts of artemisinin to justify an isolation on a technical scale. Furthermore other Artemisia species were tested. We found artemisinin in only one other species. To possibly increase the amount of artemisinin during the growth period of the plant, we tested two hormone-type growth regulators on A. ANNUA strain 811. The results showed that one of them, chlormequat, was able to increase the artemisinin content by 30% over untreated plants. We also found some slight effects of the growth regulators on morphological criteria of glandular trichomes.

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Accumulation of Secondary Metabolites and Improved Size of Glandular Trichomes in Artemisia annua
Pandey, N., Tiwari, A., Rai, S. K., & Rai, S. P. (2020) · Reference series in phytochemistry · doi:10.1007/978-3-030-30185-9_31 · Cited by 6
Recent Advances to Enhance Yield of Artemisinin: A Novel Antimalarial Compound, in Artemisia annua L. Plants
Ram, M., Jain, D. C., Mishra, H., Mandal, S., & Abdin, M. Z. (2013) · Springer eBooks · doi:10.1007/978-3-642-41027-7_11 · Cited by 5
“According to (Liersch et al. 1986), chlormequat was able to increase the artemisinin contents by 30 %.”
Background
Artemisia annua (Quing-Hao): In Vitro Culture and the Production of Artemisinin
Paniego, N. B., Maligne, A. E., & Giulietti, A. M. (1993) · Biotechnology in agriculture and forestry · doi:10.1007/978-3-642-58062-8_5 · Cited by 5
Histomorphometric study on the effects of Artemisia sieberi extract in mice skin
Kaboutari, J., Haydarnejad, M. S., Dehkordi, R. A. F., et al. (2015) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 4
Malariawirksame Verbindungen aus Pflanzen, insbesondere Peroxide [1]
Rüċker, G. (1995) · Pharmazie in unserer Zeit · doi:10.1002/pauz.19950240408 · Cited by 4
Artemisia Annua L.: Agro-Techniques for Semi-Arid Environments
Scarcella, M., Grassi, F., & Mastrorilli, M. (2011) · Italian Journal of Agronomy · doi:10.4081/ija.2011.e26 · Cited by 3
“Some authors reported artemisinin being highest during pre-flowering stages (Acton et al., 1985; Liersch et al., 1986; El-Sohly, 1990; Woerdenbag et al., 1991), whereas other results showed that artemisinin reaching its peak during flowering (Singh et al.”
BackgroundResultInfluential
Influence of planting density and development stage on photosynthetically absorbed radiation, biomass and artemisinin yield of Artemisia annua L. ‘Apollon’
Carlen, C., Koch, S., Christ, B., & Simonnet, X. (2023) · Acta Horticulturae · doi:10.17660/actahortic.2023.1358.13 · Cited by 3
INVITED REVIEW: ARTEMISININ: THE BIOSYNTHETIC PATHWAY AND ITS REGULATION IN ARTEMISIA ANNUA, A TERPENOID-RICH SPECIES
Weathers, P. J., Elkholy, S. F., & Wobbe, K. K. (2006) · Cited by 3
Transfer Of Rol Genes And Evaluation Of Artemisinin Synthesis In Transgenic Artemisia Annua L. And Artemisia Dubia Wall
Kiani, B. H. (2012) · HEC National Digital Library · Cited by 3
Trichomes in Artemisia annua: Initiation, Development, Maturation and the Possibilities to Influence these Factors
Kjær, A., Grevsen, K., & Jensen, M. (2013) · Springer eBooks · doi:10.1007/978-3-642-41027-7_7 · Cited by 2
Accumulation of Secondary Metabolites and Improved Size of Glandular Trichomes in Artemisia annua
Pandey, N., Tiwari, A., Kumar, S., & Rai, S. P. (2019) · Reference series in phytochemistry · doi:10.1007/978-3-030-11253-0_31-1 · Cited by 2
Selection of suitable reference genes for reverse transcription-quantitative polymerase chain reaction normalization in Artemisia annua L. plants at different stages of growth and development
Abdin, M. Z., Ahmad, J., Nasrullah, N., Quadri, S. N., Nissar, U., & Kumar, S. B. (2019) · Pharmacognosy Magazine · doi:10.4103/pm.pm_600_18 · Cited by 2
Antimalarial Agents
Casteel, D. A. (2003) · Wiley eBooks · doi:10.1002/0471266949.bmc091 · Cited by 2
Action des gibberellines sur la production de biomasse et d'artemisinine par Artemisia annua L. cultivée en champs
Siyapata-Ntakirutimana, E., Jaziri, M. E., Homès, J., Diallo, B., & Vanhaelen, M. H. (1996) · Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) · Cited by 2
An ecological implication of glandular trichome-sequestered artemisinin: as a sink of biotic/abiotic stress-triggered singlet oxygenPreprint
He, J., Gao, Q., Liao, T., & Zeng, Q.-P. (2015) · doi:10.7287/peerj.preprints.827v1 · Cited by 2
“From artemisinin determination throughout the vegetative stage of A. annua, it is known that top leaves exhibit generally higher artemisinin content, while bottom leaves display lower artemisinin content (Liersch et al. 1986; Ferreira et al. 1995).”
Background
Phytochemical Composition of Clonally Propagated Artemisia annua L. in Different Geographical Locations and Its Commercial Supplement Quality
Towler, M. J., Kellogg, J. J., & Weathers, P. J. (2026) · Molecules · doi:10.3390/molecules31111854 · Cited by 1
An Overview of Heterologous Organisms Used to Produce Artemisinin and Its Precursors
Li, X., He, H., Jianting, C., Wang, H., & Ye, H. (2012) · Chinese Bulletin of Botany · doi:10.3724/sp.j.1259.2012.00571 · Cited by 1
“Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathways.”
Influential
Malaria Parasites, Traditional Medicinal Plants and Artediffusin (Tehranolide) as a New Candidate of Antimalaria Agent
Rustaiyan, A., & Vahedi, M. (2012) · Journal of Biologically Active Products from Nature · doi:10.1080/22311866.2012.10719127 · Cited by 1
Studies on the Cultivation and Breeding of Artemisia annua L.
Tu, Y. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-811655-5.00007-6 · Cited by 1
Biologically active substances of the annual wormwood (Artemisia annua L.) and their use in the therapy of malaria
Navrátilová, Z., & Patočka, J. (2012) · Kontakt · doi:10.32725/kont.2012.050 · Cited by 1
An ecological implication of glandular trichome-sequestered artemisinin: as a sink of biotic/abiotic stress-triggered singlet oxygenPreprint
He, J., Gao, Q., Liao, T., & Zeng, Q.-P. (2015) · doi:10.7287/peerj.preprints.827 · Cited by 1
The Cytotoxic, Antibacterial and Free Radical Scavenging Activities of Crude Extracts of Matricaria chamomilla, Salvadora persica and Artemisia annua
Seddek, A. (2011) · King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology) · doi:10.25781/kaust-qc688
“A famous anti-malarial compound, called artemisinin, has been isolated from different species of Artemisia, including Artemisia annua [68].”
Background
Growing, harvest and postharvest processing of Artemisia annua L.
Doctora, I., & de Investigación, C. (2010)

Authors: Liersch, R., Soicke, H., Stehr, C., & Tüllner, H.-U.
Venue: Planta Medica
Publisher: Georg Thieme Verlag KG
Published: 1986-10
Volume: 52
Issue: 05
Pages: 387-390
ISSN: 0032-0943 (ISSN-L)
1439-0221
DOI: 10.1055/s-2007-969193
OpenAlex: W2073095771
Cited by: 107
References: 0
Citations by year: 2026: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 8 · 2014: 2 · 2013: 4 · 2012: 8
FWCI: 0.14
Type: journal article
Language: en
Open access: closed
Locations: Planta Medica (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant tissue culture and regeneration
Keywords: artemisinin, Artemisia annua, antimalarial compounds, plant growth stages, flowering, plant development, artemisinin content, chlormequat chloride, plant growth regulators, glandular trichomes

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Formation of Artemisinin in Artemisia annua During One Vegetation Period*,1

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