On the possible role of qinghao acid in the biosynthesis of artemisinin
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Photooxygenation of artemisinic acid (473) in vitro leads to arteannuin B (462) and 11,13-dehydro analogues of artemisinin.
“There is indeed ample precedent for the formation of such hydroperoxides from 473 by photooxygenation reactions in vitro [243], which lead both to arteannuin B (462) [251] and 11,13-dehydro analogues of artemisinin [254,308].”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [251]
Cites
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The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)
Brown, G. D. (2010) · Molecules · doi:10.3390/molecules15117603 · Cited by 363 · see citing works
In vivo transformations of dihydroartemisinic acid in Artemisia annua plants
Brown, G. D., & Sy, L.-K. (2004) · Tetrahedron · doi:10.1016/j.tet.2003.11.070 · Cited by 183 · see citing works
Responses of L. to lead and salt-induced oxidative stress
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Artemisinin: current state and perspectives for biotechnological production of an antimalarial drug
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In vivo transformations of artemisinic acid in Artemisia annua plants
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Synthesis of (+)-artemisinin and (+)-deoxoartemisinin from arteannuin B and arteannuic acid
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Selection and micropropagation of high artemisinin producing clones of <i>Artemisia annua</i> L.
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Self-citationSynthesis of labelled dihydroartemisinic acid
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- Authors
- El-Feraly, F. S., Al-Meshal, I. A., Al-Yahya, M. A., & Hifnawy, M. S.
- Affiliations
- King Saud University (SA)
- Venue
- Phytochemistry
- Publisher
- Elsevier BV
- Published
- 1986-01
- Volume
- 25
- Issue
- 12
- Pages
- 2777-2778
- ISSN
- 0031-9422 (ISSN-L)
- OpenAlex
- W2042768640
- Cited by
- 41
- References
- 7
- Citations by year
- 2025: 1 · 2024: 1 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2014: 1 · 2013: 2
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytochemistry (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical compounds biological activities
- Keywords
- artemisinin biosynthesis, arteannuin B, Artemisia annua, sesquiterpenes, singlet oxygen, photooxygenation, biogenetic precursor, antimalarial compounds
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