Cited by 125Sesquiterpenes and Asteraceae StudiesPhytochemistry and Biological ActivitiesPlant chemical constituents analysis

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Studies on the Constituents of Artemisia annua Part II*

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You-you, Tu, Mu-yun, Ni, Yu-rong, Zhong, Lan-na, Li, Shu-lian, Cui, Mu-qun, Zhang, Xiu-zhen, Wang, Zheng, Ji, Xiao-tian, Liang·1982·Planta Medica

DOI 10.1055/s-2007-971424

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Abstract

The present paper is a continuation of our study on the Chinese traditional herb Artemisia annua L. [1-5], describing several additional constituents: quinghaosu IV and V (V, VII), quinghao acid (VIII) [6], chrysosplenol (VIa) [7] and a paraffinic alcohol; V, VII and VIII are compounds with unreported structures. Key Word Index Artemisia annua L. - Compositae - Qinghaosu - Qinghaosu I-V - Qinghao acid - Flavones - Alkanol - Scopoletin - Essential oil

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I) Cooperative research group on the structure of qinghaosu: Kexue Toiigbao 22, 142 (1977).
Liu,J.M.,M.Y.Ni,J.F.Fan, Y. Y. Tu, Z. H. Wu. Y. L. Wu and W. S. Zhou: Acta Chimica Sinica 37, 129 (1979).
Journal reporter: J. New Med. /,10(1979).
Cooperative research group on qinghaosu: Yaoxue Tongbao /4,49 (1979).
Tu, Y. Y., M. Y. Ni. Y. R. Zhong. L. N. Li, S. L. Cui, M. 0. Zhang, X. Z. Wang and X. T. Liang: Acta Pharm. Sinica /6, 366 (1981).
Ghisalberti, F. L., P. R. Jeffe- ries and C. I. Stacey: Aust. J. Chem. 20(5), 1049 (1967).
Jeremic, D., A. Jokic, A. Beh- bud and M. Stefanovic: Tetrahe- dron Letters 32,3039(1973).
Vlahav, R., M. Hoiub and V. Herout: Coil. Czech. Chem. Comm. 32, 822 (1967).
Liang. X. T.: NMR, Analysis and Appiications of High Resoiu- tion Proton Spectra (in Chinese), p. 268, Science Press (1976).
Ryhage, R. and E. Stenha- gen: J. Lipid Research 1, 361 (1960).

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Connolly, J. D., & Hill, R. A. (1991) · Springer eBooks · doi:10.1007/978-1-4899-4513-6_3 · Cited by 6
Biotransformation of artemisinic acid by the fungus Trichothecium roseum and anti-candidal activity of its metabolites
Singh, P., Kapkoti, D. S., Singh, N., Tewari, R., Saikia, D., Rout, P. K., Pandey, R., & Bhakuni, R. S. (2019) · Biocatalysis and Biotransformation · doi:10.1080/10242422.2018.1552265 · Cited by 5
“All the protons and carbons of the compound 4 were assigned by the analysis of its 1H, 13C, DEPT and HMBC, NMR spectra and compared with spectral data reported for artemisinic acid (You-You et al. 1982; Jung et al. 1986).”
Background
Artemisinin is highly soluble in polyethylene Glycol 4000 and such solution has multiple biological effects
Dai, F., Bao, Y. J., Li, Z., Chen, S., Gao, L.-Z., Liu, Z.-L., Cheng, L., Peng, Y., & Tong, X. (2020) · Acta Biochimica Polonica · doi:10.18388/abp.2020_5190 · Cited by 5
Artemisia annua (Quing-Hao): In Vitro Culture and the Production of Artemisinin
Paniego, N. B., Maligne, A. E., & Giulietti, A. M. (1993) · Biotechnology in agriculture and forestry · doi:10.1007/978-3-642-58062-8_5 · Cited by 5
Evaluation of Achyranthes aspera shoot extract as an alternative therapy for malaria
Mankilik, M. M., Longdet, I. Y., & Luka, C. D. (2021) · The Journal of Basic and Applied Zoology · doi:10.1186/s41936-021-00211-4 · Cited by 4
Modification of the sesquiterpene lactone arteannuin B and antimicrobial activities of the products obtained
Abduazimov, B. K., Zoirova, K. T., Sham’yanov, I. D., et al. (1997) · Chemistry of Natural Compounds · doi:10.1007/bf02254803 · Cited by 4
Use of Sargassum fusiforme Extract and its Bioactive Molecules to inhibit HIV Infection: Bridging Two Paradigms between Eastern and Western Medicine
Guo, H., Liu, Y., Paskaleva, E. E., et al. (2014) · Chinese Herbal Medicines · doi:10.1016/s1674-6384(14)60041-1 · Cited by 4
“…antimalarial drug artemisinin that was extracted from Artemisia annua L. by cold water (Chen et al, 2012; Tu et al, 1981; Klayman, 1985; Tu, 2011; You-You et al, 1982), and FDA approved arsenic trioxide (trisenox) that was traditionally used to treat acute promyelocytic leukemia (APL) (Kwong and…”
Method
Mechanistic Insights into the Nonenzymatic Biosynthesis of Artemisinin and Related Natural Products: A Quantum Chemical Study
Yan, M., Ding, X., Zhao, L., Lü, X., He, H., Fan, S., & Yang, Z. (2025) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.5c00034 · Cited by 3
A critical review on rubriflordilactones A, B, and C: occurrence, structural diversity, bioactivities, and synthesis
Bansal, D., Sivaganesan, P., Elanchezhian, C., et al. (2025) · Organic & Biomolecular Chemistry · doi:10.1039/d5ob01614b · Cited by 3
Plants with antimalarial properties: A systematic review of the current clinical evidence
Aracil, A., & Green, J. (2019) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2019.04.005 · Cited by 3

Authors: You-you, T., Mu-yun, N., Yu-rong, Z., Lan-na, L., Shu-lian, C., Mu-qun, Z., Xiu-zhen, W., Zheng, J., & Xiao-tian, L.
Affiliations: Institute of Chinese Materia Medica (CN)
ORCID: Zheng, Ji
Venue: Planta Medica
Publisher: Georg Thieme Verlag KG
Published: 1982-03
Volume: 44
Issue: 03
Pages: 143-145
ISSN: 0032-0943 (ISSN-L)
1439-0221
DOI: 10.1055/s-2007-971424
OpenAlex: W1971899040
Cited by: 125
References: 0
Citations by year: 2026: 2 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 9 · 2020: 9 · 2019: 4 · 2018: 6 · 2017: 4 · 2016: 10 · 2015: 2 · 2014: 4 · 2013: 4 · 2012: 1
FWCI: 0.55
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Planta Medica (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant chemical constituents analysis
Keywords: Artemisia annua, scopoletin, flavones, essential oils, natural compounds, traditional Chinese medicine

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Studies on the Constituents of Artemisia annua Part II*

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