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Cited by 147Muscle metabolism and nutritionSports Performance and TrainingExercise and Physiological Responses

Influence of paroxetine, branched-chain amino acids and tyrosine on neuroendocrine system responses and fatigue in humans

Strüder, H., Hollmann, W., Platen, P., Donike, M., Gotzmann, A., Weber, K.·1998·Hormone and Metabolic Research
DOI 10.1055/s-2007-978864
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Abstract

Effects of a serotonin re-uptake inhibitor and oral amino acid supplementations on physical and mental performance as well as neuroendocrine variables were investigated. 10 male subjects cycled in four trials until exhaustion. Participants ingested a placebo in trial (T) I, 20 mg paroxetine in T II, 21 g branched-chain amino acids (BCAA) in T III and 20g tyrosine (TYR) in T IV. Heart rate, capillary lactate, plasma insulin, free fatty acids, glucose, serotonin and beta-endorphin did not differ in trials. Plasma ammonia increments during exercise were higher in T III. Plasma BCAA in T III and plasma TYR in T IV were increased after 30 min of exercise according to the supplemented substances. In contrast to all other trials, the ratio of plasma free TRP/BCAA did not increase in T III. Plasma TYR/BCAA was augmented in T IV and decreased in T III after 30 min of exercise, whereas it did not change in T I and II. Plasma prolactin (PRL), growth hormone, cortisol, adrenocorticotropic hormone, norepinephrine and epinephrine increased during all trials. Plasma PRL increments were higher in T IV. Exhaustion was reached earlier in T II. No significant differences were found between other trials. Drive during psychometric testing subsequent to exercise was improved in T III and IV. The results indicate that fatigue during endurance exercise was increased by pharmacological augmentation of the brain serotonergic activity. However, a reduction of 5-HT synthesis via BCAA supplementation did not affect physical fatigue. TYR administration did not alter physical performance either although plasma PRL increments suggest that changes in the monoaminergic system were induced. Precaution is necessary before assuming an ergogenic value of amino acids.

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  • All seven studies that measured plasma tyrosine levels found significantly elevated levels after tyrosine intake compared to placebo.

    “All seven studies in which plasma tyrosine levels were measured (Strüder et al., 1998;Sutton et al., 2005;Shurtleff et al., 1994;Chinevere et al., 2002;Tumilty et al., 2011Tumilty et al., , 2014;;Watson et al., 2012) found these levels to be significantly elevated after tyrosine intake compared to placebo.”

    From Behavioral and cognitive effects of tyrosine intake in healthy human adults (2015) · cites this paper as Strüder et al., 1998

  • Among six studies of endurance exercise performance in physically trained young men, five found no significant difference between tyrosine and placebo, while one found tyrosine enhanced performance.

    “While one study found tyrosine to enhance endurance exercise performance (Tumilty et al., 2011), five studies found no significant differences between tyrosine and the placebo (Strüder et al., 1998;Sutton et al., 2005;Chinevere et al., 2002;Tumilty et al., 2014;Watson et al., 2012).”

    From Behavioral and cognitive effects of tyrosine intake in healthy human adults (2015) · cites this paper as Strüder et al., 1998

  • One study observed acute tyrosine-induced elevations in prolactin during exercise.

    “The other study observed acute tyrosine-induced elevations in prolactin during exercise (Strüder et al., 1998).”

    From Behavioral and cognitive effects of tyrosine intake in healthy human adults (2015) · cites this paper as Strüder et al., 1998

  • The release of prolactin from the anterior pituitary is inhibited by dopamine in the brain.

    “This was unexpected because the release of prolactin from the anterior pituitary is inhibited, rather than stimulated, by dopamine in the brain (Strüder et al., 1998;Harmer et al., 2001).”

    From Behavioral and cognitive effects of tyrosine intake in healthy human adults (2015) · cites this paper as Strüder et al., 1998

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Authors
Strüder, H., Hollmann, W., Platen, P., Donike, M., Gotzmann, A., & Weber, K.
Affiliations
German Sport University Cologne (DE)
ORCID
Venue
Hormone and Metabolic Research
Publisher
Georg Thieme Verlag KG
Published
1998-04
Volume
30
Issue
04
Pages
188-194
ISSN
  • 0018-5043 (ISSN-L)
  • 1439-4286
DOI
10.1055/s-2007-978864
OpenAlex
W2003294099
Cited by
147
References
0
Citations by year
2026: 4 · 2024: 3 · 2023: 2 · 2022: 7 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 6 · 2016: 5 · 2015: 15 · 2014: 8 · 2013: 6 · 2012: 6
FWCI
0.98
Type
journal article
Language
en
Open access
closed
Locations
  • Hormone and Metabolic Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Bundesinstitut für Sportwissenschaft
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
paroxetine, branched-chain amino acids, tyrosine, amino acid supplementation, exercise fatigue, endurance exercise, serotonin, prolactin, growth hormone, cortisol, ACTH, plasma free tryptophan, blood ammonia, ergogenic aids, psychometric performance
MeSH terms
Adult, Amino Acids, Branched-Chain, Exercise Test, Fatigue, Humans, Male, Neurosecretory Systems, Psychometrics, Tyrosine, Selective Serotonin Reuptake Inhibitors, Paroxetine

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