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Cited by 102Sports Performance and TrainingCardiovascular and exercise physiologyMuscle metabolism and nutrition

Enzymatic adaptations consequent to long-term strength training

Tesch, P., Komi, P., Häkkinen, K.·1987·International Journal of Sports Medicine
DOI 10.1055/s-2008-1025706
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Abstract

The muscle enzymatic changes subsequent to 6 months of strength training followed by 3 months of detraining were examined in 21 physically active men. They were assigned either to a heavy-resistance (HR) or an explosive strength (EX) training program. Muscle biopsies were obtained from m. vastus lateralis for the assessment of activities of the enzymes hexokinase (HK), myofibrillar ATPase (ATPase), citrate synthase (CS), phosphofructokinase (PFK), lactate dehydrogenase (LDH), myokinase (MK) and creatine kinase (CK). The activities were measured on freeze-dried tissue samples using fluorometrical assays. Both groups displayed increased (P less than 0.01-0.001) fast-twitch (FT) fiber area consequent to training with no concomitant hypertrophy of slow-twitch (ST) fiber area. Mean fiber area increased by 16% (P less than 0.001) in HR and 9% (NS) in EX. Following detraining, mean fiber area returned to pretraining value only in EX. HK decreased in both groups (P less than 0.01-0.001) and CK decreased in HR (P less than 0.05). When the two groups were treated together, all enzymes, except for LDH, decreased their activity (P less than 0.05-0.001). It is concluded that 6 months of strength training performed either as heavy-resistance or explosive training is not associated with any increased activities of enzymes reflecting phosphagen, glycolytic, or oxidative metabolism. Instead, the present results suggest that exercise-induced hypertrophy is accompanied by attenuation of certain enzyme activities of importance for ATP regeneration.

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  • Resistance training does not alter or decreases mitochondrial volume as measured by citrate synthase activity assays or transmission electron microscopy.

    “Separate reports have also shown that resistance training does not alter or decreases mitochondrial volume (as measured by citrate synthase activity assays or transmission electron microscopy; Macdougall et al., 1982; Luthi et al., 1986; Tesch et al., 1987; Parise et al., 2005; Porter et al., 2015)”

    From Skeletal Muscle Ribosome and Mitochondrial Biogenesis in Response to Different Exercise Training Modalities (2021) · cites this paper as Tesch et al., 1987

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Authors
Tesch, P., Komi, P., & Häkkinen, K.
Affiliations
  • Karolinska Institutet (SE)
  • University of Jyväskylä (FI)
Venue
International Journal of Sports Medicine
Publisher
Georg Thieme Verlag KG
Published
1987-03
Volume
08
Issue
S 1
Pages
S66-S69
ISSN
  • 0172-4622 (ISSN-L)
  • 1439-3964
DOI
10.1055/s-2008-1025706
OpenAlex
W2040511859
Cited by
101
References
0
Citations by year
2024: 1 · 2023: 5 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 4 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 6 · 2013: 2
FWCI
4.78
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Sports Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
resistance training, detraining, muscle enzyme activity, high-load resistance training, explosive strength training, vastus lateralis, hexokinase, creatine kinase, myofibrillar ATPase, citrate synthase, phosphofructokinase, lactate dehydrogenase, adenylate kinase, ATP regeneration, glycolytic metabolism, oxidative metabolism, muscle hypertrophy
MeSH terms
Adenosine Triphosphatases, Adenylate Kinase, Adult, Body Constitution, Citrate (si)-Synthase, Creatine Kinase, Hexokinase, Histocytochemistry, Humans, L-Lactate Dehydrogenase, Male, Muscles, Phosphofructokinase-1, Physical Education and Training

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