Resistance exercise training alters mitochondrial function in human skeletal muscle
Open accessAbstract
INTRODUCTION: Loss of mitochondrial competency is associated with several chronic illnesses. Therefore, strategies that maintain or increase mitochondrial function will likely be of benefit in numerous clinical settings. Endurance exercise has long been known to increase mitochondrial function in the skeletal muscle. Comparatively little is known regarding the effect of resistance exercise training (RET) on skeletal muscle mitochondrial respiratory function. PURPOSE: The purpose of the current study was to determine the effect of chronic resistance training on skeletal muscle mitochondrial respiratory capacity and function. METHODS: Here, we studied the effect of a 12-wk RET program on skeletal muscle mitochondrial function in 11 young healthy men. Muscle biopsies were collected before and after the 12-wk training program, and mitochondrial respiratory capacity was determined in permeabilized myofibers by high-resolution respirometry. RESULTS: RET increased lean body mass and quadriceps muscle strength by 4% and 15%, respectively (P < 0.001). Coupled mitochondrial respiration supported by complex I, and complex I and II substrates increased by 2- and 1.4-fold, respectively (P < 0.01). The ratio of coupled complex I-supported respiration to maximal respiration increased with RET (P < 0.05), as did complex I protein abundance (P < 0.05), whereas the substrate control ratio for succinate was reduced after RET (P < 0.001). Transcripts responsible for proteins critical to electron transfer and NAD production increased with training (P < 0.05), whereas transcripts involved in mitochondrial biogenesis were unaltered. CONCLUSIONS: Collectively, 12 wk of RET resulted in qualitative and quantitative changes in skeletal muscle mitochondrial respiration. This adaptation was accompanied by modest changes in mitochondrial proteins and transcript expression. RET seems to be a means to augment the respiratory capacity and intrinsic function of skeletal muscle mitochondria.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Resistance training helps mitigate these effects by maintaining muscle mass and preserving metabolic capacity, including mitochondrial function and glucose utilization.
“Resistance training helps mitigate these effects by maintaining muscle mass and preserving metabolic capacity, including mitochondrial function and glucose utilization.”
From Weight maintenance after discontinuation of GLP-1 therapies (2026) · cites this paper as [77]
The Results report increased lean body mass and mitochondrial respiration after 12 weeks of resistance training, supporting the muscle-mass and mitochondrial-function parts of the claim. The paper does not report glucose utilization, so that part is unsupported. (LLM, conf=0.87)
Experimental — accuracy not yet measuredPRT increases mitochondrial protein fractional synthesis rates and improves mitochondrial function.
“strong evidence shows that PRT increases mitochondrial protein fractional synthesis rates [119,371] and improves mitochondrial function [119,372].”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [372]
Strong evidence shows that PRT increases mitochondrial protein fractional synthesis rates and improves mitochondrial function.
“More recently, strong evidence shows that PRT increases mitochondrial protein fractional synthesis rates [119,371] and improves mitochondrial function [119,372].”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [372]
Endurance and resistance exercise have both been linked to increased mitochondrial biogenesis.
“Both endurance and resistance exercise have been associated with elevated mitochondrial biogenesis (93, 109).”
From Mitochondria initiate and regulate sarcopenia (2017) · cites this paper as [109]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works
Srere, P. A. (1969) · Methods in Enzymology · doi:10.1016/0076-6879(69)13005-0 · Cited by 2,005 · see citing works
Biochemical Adaptations in Muscle
Holloszy, J. O. (1967) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)96046-1 · Cited by 1,517 · see citing works
Decline in skeletal muscle mitochondrial function with aging in humans
Short, K. R., Bigelow, M. L., Kahl, J., Singh, R., Coenen-Schimke, J., Raghavakaimal, S., & Nair, K. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501559102 · Cited by 1,333 · see citing works
Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects
Larsen, S., Nielsen, J., Hansen, C. N., Nielsen, L. B., Wibrand, F., Stride, N., Schroder, H. D., Boushel, R., Helge, J. W., Dela, F., et al. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.230185 · Cited by 1,180 · cited 2× · see citing works
“CS activity is often reported as a biochemical read-out of skeletal muscle oxidative capacity (18).”
BackgroundMethodPercutaneous Needle Biopsy of Skeletal Muscle in Physiological and Clinical Research
Bergström, J. P. (1975) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365517509095787 · Cited by 1,159 · see citing works
Dreyer, H. C., Fujita, S., Cadenas, J. G., Chinkes, D. L., Volpi, E., & Rasmussen, B. B. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.113175 · Cited by 570 · see citing works
Self-citationPatients with type 2 diabetes have normal mitochondrial function in skeletal muscle
Boushel, R., Gnaiger, E., Schjerling, P., Skovbro, M., Kraunsøe, R., & Dela, F. (2007) · Diabetologia · doi:10.1007/s00125-007-0594-3 · Cited by 519 · see citing works
Capacity of oxidative phosphorylation in human skeletal muscle
Gnaiger, E. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.03.013 · Cited by 446 · see citing works
Bell, G. J., Syrotuik, D., Martin, T. P., Burnham, R., & Quinney, H. A. (2000) · European Journal of Applied Physiology · doi:10.1007/s004210050063 · Cited by 411 · see citing works
Effects of exercise on mitochondrial content and function in aging human skeletal muscle
Menshikova, E. V., Ritov, V. B., Fairfull, L., Ferrell, R. E., Kelley, D. E., & Goodpaster, B. H. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.6.534 · Cited by 398 · see citing works
Mitochondrial citric acid cycle and related enzymes: Adaptive response to exercise
Holloszy, J. O., Oscai, L. B., Don, I., & Mole, P. A. (1970) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(70)90017-3 · Cited by 314 · see citing works
Skeletal muscle NAMPT is induced by exercise in humans
Costford, S. R., Bajpeyi, S., Pasarica, M., Albarado, D. C., Thomas, S. C., Xie, H., Church, T. S., Jubrias, S. A., Conley, K. E., & Smith, S. R. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00318.2009 · Cited by 297 · see citing works
Plasticity of skeletal muscle mitochondria: structure and function.
HOPPELER, H., & FL??CK, M. (2003) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200301000-00016 · Cited by 267 · see citing works
Effect of resistance training on muscle use during exercise
Ploutz, L. L., Tesch, P. A., Biro, R. L., & Dudley, G. A. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.76.4.1675 · Cited by 256 · see citing works
Drummond, M., Glynn, E., Fry, C., Timmerman, K., Volpi, E., & Rasmussen, B. (2010) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00690.2009 · Cited by 231 · see citing works
Self-citationJacobs, R. A., & Lundby, C. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01081.2012 · Cited by 222 · see citing works
Structural changes in skeletal muscle tissue with heavy-resistance exercise
Lüthi, J., Howald*, H., Claassen, H., Rösler, K., Vock**, P., & Hoppeler, H. (1986) · International Journal of Sports Medicine · doi:10.1055/s-2008-1025748 · Cited by 221 · cited 1× · see citing works
“many other studies have also shown that mitochondrial density (21) and the activity of oxidative enzymes thought to reflect”
BackgroundGreen, H., Goreham, C., Ouyang, J., Ball-Burnett, M. E., & Ranney, D. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.2.r591 · Cited by 198 · see citing works
Mitochondrial volume density in human skeletal muscle following heavy resistance training.
Jd, M., SALE, D. G., Мороз, Gc, E., Sutton, M. A., & HOWALD, H. (1979) · PubMed · Cited by 191 · see citing works
Effects of weight loss and physical activity on skeletal muscle mitochondrial function in obesity
Menshikova, E. V., Ritov, V. B., Toledo, F. G. S., Ferrell, R. E., Goodpaster, B. H., & Kelley, D. E. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00322.2004 · Cited by 189 · see citing works
Physical activity changes the regulation of mitochondrial respiration in human skeletal muscle
Zoll, J., Sanchez, H., N’guessan, B. B., Ribera, F., Lampert, E., Bigard, X. A., Serrurier, B., Fortin, D., Gény, B., Veksler, V., et al. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.019661 · Cited by 186 · see citing works
Effect of acute exercise on citrate synthase activity in untrained and trained human skeletal muscle
Leek, B. T., Mudaliar, S. R. D., Henry, R. R., Mathieu-Costello, O. A., & Richardson, R. S. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.2.r441 · Cited by 184 · see citing works
Suetta, C., Andersen, J. L., Dalgas, U., Berget, J., Koskinen, S., Aagaard, P., Magnusson, S. P., & Kjaer, M. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01354.2007 · Cited by 184 · see citing works
Pesta, D. H., Hoppel, F., Macek, C., Messner, H., Faulhaber, M., Kobel, C., Parson, W., Burtscher, M., Schocke, M. F. H., & Gnaiger, E. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00285.2011 · Cited by 181 · see citing works
Molecular Adaptations to Aerobic Exercise Training in Skeletal Muscle of Older Women
Konopka, A. R., Douglass, M. D., Kaminsky, L. A., Jemioło, B., Trappe, T. A., Trappe, S. W., & Harber, M. P. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq109 · Cited by 123 · see citing works
Tang, J. E., Hartman, J. W., & Phillips, S. M. (2006) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h06-026 · Cited by 116 · see citing works
Effects of physical training on exercise blood flow and enzymatic activity in skeletal muscle
Varnauskas, E., Björntorp, P. A., Fahlén, M., Přerovský, I., & Stenberg, J. (1970) · Cardiovascular Research · doi:10.1093/cvr/4.4.418 · Cited by 106 · see citing works
Wang, N., Hikida, R. S., Staron, R. S., & Simoneau, J. (1993) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00374913 · Cited by 103 · see citing works
Enzymatic adaptations consequent to long-term strength training
Tesch, P., Komi, P., & Häkkinen, K. (1987) · International Journal of Sports Medicine · doi:10.1055/s-2008-1025706 · Cited by 101 · see citing works
Plasticity of skeletal muscle mitochondria: structure and function.
Hoppeler, H. H., & Flück, M. (2003) · PubMed · doi:10.1249/01.mss.0000043292.99104.12 · Cited by 92 · see citing works
Larsen, S., Ara, I., Rabøl, R., Andersen, J. L., Boushel, R., Dela, F., & Helge, J. W. (2009) · Diabetologia · doi:10.1007/s00125-009-1353-4 · Cited by 90 · see citing works
Detection of Autologous Blood Transfusions in Cross-Country Skiers
Berglund*, B., Hemmingsson, P., & Birgegård, G. (1987) · International Journal of Sports Medicine · doi:10.1055/s-2008-1025643 · Cited by 87 · see citing works
Tesch, P. A., THORSSON, A., & Colliander, E. B. (1990) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1990.tb09035.x · Cited by 81 · see citing works
Chilibeck, P. D., Syrotuik, D. G., & Bell, G. J. (1999) · European Journal of Applied Physiology and Occupational Physiology · doi:10.1007/s004210050641 · Cited by 74 · see citing works
Stepto, N., Benziane, B., Wadley, G., Chibalin, A., Canny, B., Eynon, N., & McConell, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0053080 · Cited by 68 · see citing works
Salvadego, D., Domenis, R., Lazzer, S., Porcelli, S., Rittweger, J., Rizzo, G., Mavelli, I., Šimunič, B., Pišot, R., & Grassi, B. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00883.2012 · Cited by 68 · see citing works
Uncoupled skeletal muscle mitochondria contribute to hypermetabolism in severely burned adults
Porter, C. C., Herndon, D. N., Børsheim, E., Chao, T., Reidy, P. T., Borack, M. S., Rasmussen, B. B., Chondronikola, M., Saraf, M. K., & Sidossis, L. S. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00206.2014 · Cited by 67 · see citing works
Self-citationGreen, DAHLY, Shoemaker, GOREHAM, BOMBARDIER, & BALL‐BURNETT (1999) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1999.00484.x · Cited by 64 · see citing works
Alvehus, M., Boman, N., Söderlund, K., Svensson, M., & Burén, J. (2014) · European Journal of Applied Physiology · doi:10.1007/s00421-014-2879-9 · Cited by 39 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Malm, C., Jakobsson, J., & Isaksson, A. (2019) · Sports · doi:10.3390/sports7050127 · Cited by 664 · see citing works
Maintenance of Skeletal Muscle Mitochondria in Health, Exercise, and Aging
Hood, D. A., Memme, J. M., Oliveira, A. N., & Triolo, M. (2019) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114310 · Cited by 567 · see citing works
“Invisible sportswomen”: The sex data gap in sport and exercise science research
Cowley, E. S., Olenick, A. A., McNulty, K. L., & Ross, E. Z. (2021) · Women in Sport and Physical Activity Journal · doi:10.1123/wspaj.2021-0028 · Cited by 449 · see citing works
Exercise and mitochondrial health
Memme, J. M., Erlich, A. T., Phukan, G., & Hood, D. A. (2021) · The Journal of Physiology · doi:10.1113/jp278853 · Cited by 343 · see citing works
Exercise Metabolism and Adaptation in Skeletal Muscle
Smith, J. A. B., Murach, K. A., Dyar, K. A., & Zierath, J. R. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00606-x · Cited by 342 · see citing works
Singh, A., D'Amico, D. F., Andreux, P. A., Fouassier, A. M., Blanco-Bose, W. E., Evans, M., Aebischer, P., Auwerx, J. H., & Rinsch, C. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100633 · Cited by 276 · see citing works
Egan, B., & Sharples, A. P. (2023) · Physiological Reviews · doi:10.1152/physrev.00054.2021 · Cited by 278 · see citing works
Izquierdo, M., de Souto Barreto, P., Arai, H., Bischoff-Ferrari, H. A., Cadore, E. L., Cesari, M., Chen, L.-K., Coen, P. M., Courneya, K. S., Duque, G., et al. (2025) · The Journal of nutrition, health and aging · doi:10.1016/j.jnha.2024.100401 · Cited by 273 · see citing works
Roberts, M. D., McCarthy, J. J., Hornberger, T. A., Phillips, S. M., Mackey, A. L., Nader, G. A., Boppart, M. D., Kavazis, A. N., Reidy, P. T., Ogasawara, R., et al. (2023) · Physiological Reviews · doi:10.1152/physrev.00039.2022 · Cited by 214 · see citing works
Self-citationMitochondria as a Target for Mitigating Sarcopenia
Coen, P. M., Musci, R., Hinkley, J., & Miller, B. F. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2018.01883 · Cited by 140 · see citing works
Burtscher, J., Millet, G. P., Place, N., Kayser, B., & Zanou, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126479 · Cited by 159 · see citing works
Mitochondria initiate and regulate sarcopenia
Alway, S. E., Mohamed, J. S., & Myers, M. J. (2017) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000101 · Cited by 153 · see citing works
“Both endurance and resistance exercise have been associated with elevated mitochondrial biogenesis (93,109).”
BackgroundImpact of Resistance Training on Skeletal Muscle Mitochondrial Biogenesis, Content, and Function
Groennebaek, T., & Vissing, K. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00713 · Cited by 154 · see citing works
Exercise Induces Tissue-Specific Adaptations to Enhance Cardiometabolic Health
Ashcroft, S. P., Stocks, B., Egan, B., & Zierath, J. R. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2023.12.008 · Cited by 149 · see citing works
Holloway, G. P., Holwerda, A. M., Miotto, P. M., Dirks, M. L., Verdijk, L. B., & van Loon, L. J. C. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.069 · Cited by 134 · see citing works
The effects of real and simulated microgravity on cellular mitochondrial function
Nguyen, H. P., Tran, P. H., Kim, K., & Yang, S. (2021) · npj Microgravity · doi:10.1038/s41526-021-00171-7 · Cited by 133 · see citing works
Repeated exposure to heat stress induces mitochondrial adaptation in human skeletal muscle
Hafen, P. S., Preece, C. N., Sorensen, J. R., Hancock, C. R., & Hyldahl, R. D. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00383.2018 · Cited by 129 · see citing works
Mitochondrial dysfunction and skeletal muscle atrophy: Causes, mechanisms, and treatment strategies
Kubat, G. B., Bouhamida, E., Ülger, Ö., Türkel, İ., Pedriali, G., Ramaccini, D., Ekinci, Ö., Özerkliğ, B., Atalay, Ö., Patergnani, S., et al. (2023) · Mitochondrion · doi:10.1016/j.mito.2023.07.003 · Cited by 128 · see citing works
Impact of Endurance and Resistance Training on Skeletal Muscle Glucose Metabolism in Older Adults
Consitt, L. A., Dudley, C., & Saxena, G. (2019) · Nutrients · doi:10.3390/nu11112636 · Cited by 116 · see citing works
Glycogen availability and skeletal muscle adaptations with endurance and resistance exercise
Knuiman, P., Hopman, M. T. E., & Mensink, M. (2015) · Nutrition & Metabolism · doi:10.1186/s12986-015-0055-9 · Cited by 113 · see citing works
Franklin, B. A., Eijsvogels, T. M. H., Pandey, A., Quindry, J. C., & Toth, P. P. (2022) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2022.100424 · Cited by 128 · see citing works
Scandalis, L., Kitzman, D. W., Nicklas, B. J., Lyles, M. F., Brubaker, P. H., Nelson, M. B., Gordon, M., Stone, J., Bergstrom, J., Neufer, P. D., et al. (2023) · JAMA Cardiology · doi:10.1001/jamacardio.2023.0957 · Cited by 112 · see citing works
Understanding the Role of Exercise in Cancer Cachexia Therapy
Hardee, J. P., Counts, B. R., & Carson, J. A. (2017) · American Journal of Lifestyle Medicine · doi:10.1177/1559827617725283 · Cited by 108 · see citing works
Dose in Exercise-Based Dysphagia Therapies: A Scoping Review
Krekeler, B. N., Rowe, L. M., & Connor, N. P. (2020) · Dysphagia · doi:10.1007/s00455-020-10104-3 · Cited by 109 · see citing works
Roberts, M. D., Haun, C. T., Mobley, C. B., Mumford, P. W., Romero, M. A., Roberson, P. A., Vann, C. G., & McCarthy, J. J. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00834 · Cited by 107 · see citing works
Groennebaek, T., Jespersen, N. R., Jakobsgaard, J. E., Sieljacks, P., Wang, J., Rindom, E., Musci, R. V., Bøtker, H. E., Hamilton, K. L., Miller, B. F., et al. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01796 · Cited by 88 · see citing works
Mitochondria and Aging—The Role of Exercise as a Countermeasure
Nilsson, M. I., & Tarnopolsky, M. A. (2019) · Biology · doi:10.3390/biology8020040 · Cited by 92 · see citing works
Human Skeletal Muscle Mitochondrial Adaptations Following Resistance Exercise Training
Parry, H. A., Roberts, M. D., & Kavazis, A. N. (2020) · International Journal of Sports Medicine · doi:10.1055/a-1121-7851 · Cited by 92 · see citing works
Mitochondrial Properties in Skeletal Muscle Fiber
Dong, H., & Tsai, S. (2023) · Cells · doi:10.3390/cells12172183 · Cited by 95 · see citing works
Wang, S. Y., Zhu, S., Wu, J., Zhang, M., Xu, Y., Xu, W., Cui, J., Yu, B., Cao, W., & Liu, J. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-019-01861-2 · Cited by 91 · see citing works
Moro, T., Brightwell, C. R., Phalen, D. E., McKenna, C. F., Lane, S. J., Porter, C., Volpi, E., Rasmussen, B. B., & Fry, C. S. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110723 · Cited by 85 · see citing works
Self-citationGharahdaghi, N., Rudrappa, S. S., Brook, M. S., IDRIS, I. R., Crossland, H., Hamrock, C., Aziz, M. H. A., Kadi, F., Tarum, J., Greenhaff, P. L., et al. (2019) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12472 · Cited by 82 · see citing works
Tkaczenko, H., & Kurhaluk, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031098 · Cited by 80 · see citing works
Role of dietary protein and muscular fitness on longevity and aging
Strasser, B., Volaklis, K., Fuchs, D., & Burtscher, M. (2018) · Aging and Disease · doi:10.14336/ad.2017.0202 · Cited by 78 · see citing works
Cho, S., Shaban, S. M., Song, R., Zhang, H., Yang, D. S., Kim, M.-J., Xiong, Y., Li, X., Madsen, K. E., Wapnick, S., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.ado5366 · Cited by 71 · see citing works
Fiorenza, M., Lemminger, A. K., Marker, M., Eibye, K., Iaia, F. M., Bangsbo, J., & Hostrup, M. (2019) · The FASEB Journal · doi:10.1096/fj.201900106rrr · Cited by 69 · see citing works
Mesquita, P. H. C., Lamb, D. A., Parry, H. A., Moore, J. H., Smith, M. A., Vann, C. G., Osburn, S. C., Fox, C. D., Ruple, B. A., Huggins, K. W., et al. (2020) · Physiological Reports · doi:10.14814/phy2.14526 · Cited by 66 · see citing works
Reidy, P. T., Borack, M. S., Markofski, M. M., Dickinson, J. M., Deer, R. R., Husaini, S. H., Walker, D. K., Igbinigie, S., Robertson, S. M., Cope, M. B., et al. (2016) · The Journal of Nutrition · doi:10.3945/jn.116.231803 · Cited by 67 · see citing works
“After the DXA scan, ultrasound (Phillips HDI 5000) of the vastus lateralis (VL) and vastus intermedius was conductedwith the participant in a supine position as previously described (32).”
MethodSelf-citationThe Effects of Acute and Chronic Exercise on Skeletal Muscle Proteome
Petriz, B. A., Gomes, C. P. C., de Almeida, J. A., de Oliveira, G. P., Ribeiro, F. M., Pereira, R. W., & Franco, O. L. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25477 · Cited by 66 · see citing works
Burtscher, J., Burtscher, M., & Millet, G. P. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101976 · Cited by 65 · see citing works
Mesquita, P. H. C., Vann, C. G., Phillips, S. M., McKendry, J., Young, K. C., Kavazis, A. N., & Roberts, M. D. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.725866 · Cited by 62 · see citing works
Harper, C., Gopalan, V., & Goh, J. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02737-1 · Cited by 62 · see citing works
Influence of physical exercise on microRNAs in skeletal muscle regeneration, aging and diseases
Ultimo, S., Zauli, G., Martelli, A. M., Vitale, M., McCubrey, J. A., Capitani, S., & Neri, L. M. (2018) · Oncotarget · doi:10.18632/oncotarget.24991 · Cited by 62 · see citing works
Lamb, D. A., Moore, J. H., Mesquita, P. H. C., Smith, M. A., Vann, C. G., Osburn, S. C., Fox, C. D., Lopez, H. L., Ziegenfuss, T. N., Huggins, K. W., et al. (2020) · Aging · doi:10.18632/aging.103218 · Cited by 62 · see citing works
Mitochondrial health and muscle plasticity after spinal cord injury
Gorgey, A. S., Witt, O., O’Brien, L. C., Cardozo, C. P., Chen, Q., Lesnefsky, E. J., & Graham, Z. (2018) · European Journal of Applied Physiology · doi:10.1007/s00421-018-4039-0 · Cited by 63 · see citing works
Porter, C. C., Herndon, D. N., Børsheim, E., Bhattarai, N., Chao, T., Reidy, P. T., Rasmussen, B. B., Andersen, C. R., Suman-Vejas, O. E., & Sidossis, L. S. (2015) · Journal of Burn Care & Research · doi:10.1097/bcr.0000000000000308 · Cited by 59 · see citing works
Self-citationMitochondrial Quality Control in Sarcopenia: Updated Overview of Mechanisms and Interventions
Liu, D., Fan, Y., Tao, X., Pan, W., Wu, Y., Wang, X., He, Y., Xiao, W., & Li, Y. (2021) · Aging and Disease · doi:10.14336/ad.2021.0427 · Cited by 60 · see citing works
Liao, J., He, W., Li, L., Wang, J., Gong, L., Zhang, Q., & Lin, Z. (2025) · Cell Biomaterials · doi:10.1016/j.celbio.2025.100016 · Cited by 62 · see citing works
Hyatt, H. W., Kephart, W. C., Holland, A. M., Mumford, P. W., Mobley, C. B., Lowery, R. P., Roberts, M. D., Wilson, J. M., & Kavazis, A. N. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00533 · Cited by 57 · see citing works
Stier, A., Bize, P., Hsu, B.-Y., & Ruuskanen, S. (2019) · bioRxiv · doi:10.1098/rsbl.2019.0536 · Cited by 51 · see citing works
Redox Signaling from Mitochondria: Signal Propagation and Its Targets
Ježek, P., Holendová, B., & Plecitá-Hlavatá, L. (2020) · Biomolecules · doi:10.3390/biom10010093 · Cited by 54 · see citing works
Pignanelli, C., Petrick, H. L., Keyvani, F., Heigenhauser, G. J. F., Quadrilatero, J., Holloway, G. P., & Burr, J. F. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00243.2019 · Cited by 56 · see citing works
Mitochondrial involvement in sarcopenia
Affourtit, C., & Carré, J. E. (2024) · Acta Physiologica · doi:10.1111/apha.14107 · Cited by 58 · see citing works
Kitaoka, Y., Ogasawara, R., Tamura, Y., Fujita, S., & Hatta, H. (2015) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2015-0184 · Cited by 54 · see citing works
Post-absorptive muscle protein turnover affects resistance training hypertrophy
Reidy, P., Borack, M. S., Markofski, M., Dickinson, J., Fry, C., Deer, R., Volpi, E., & Rasmussen, B. (2017) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3566-4 · Cited by 49 · see citing works
Self-citationEnhancement of anaerobic glycolysis – a role of PGC-1α4 in resistance exercise
Koh, J., Pataky, M. W., Dasari, S., Klaus, K. A., Vučković, I., Ruegsegger, G. N., Kumar, A. P., Robinson, M. M., & Nair, K. S. (2022) · Nature Communications · doi:10.1038/s41467-022-30056-6 · Cited by 50 · see citing works
Roberts, M. D., Romero, M. A., Mobley, C. B., Mumford, P. W., Roberson, P. A., Haun, C. T., Vann, C. G., Osburn, S. C., Holmes, H. H., Greer, R. A., et al. (2018) · PeerJ · doi:10.7717/peerj.5338 · Cited by 50 · see citing works
Petrick, H. L., Pignanelli, C., Barbeau, P., Churchward‐Venne, T. A., Dennis, K. M. J. H., van Loon, L. J. C., Burr, J. F., Goossens, G. H., & Holloway, G. P. (2019) · The Journal of Physiology · doi:10.1113/jp277765 · Cited by 53 · see citing works
Adaptive responses of histone modifications to resistance exercise in human skeletal muscle
Lim, C., Shimizu, J., Kawano, F., Kim, H. J., & Kim, C. K. (2020) · PLoS ONE · doi:10.1371/journal.pone.0231321 · Cited by 48 · see citing works
Nutrients, Physical Activity, and Mitochondrial Dysfunction in the Setting of Metabolic Syndrome
Lemos, G., Torrinhas, R. S., & Waitzberg, D. L. (2023) · Nutrients · doi:10.3390/nu15051217 · Cited by 46 · see citing works
Thomas, A. C. Q., Stead, C. A., Burniston, J. G., & Phillips, S. M. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.08.010 · Cited by 52 · see citing works
Miller, M. S., Callahan, D. M., Tourville, T. W., Slauterbeck, J. R., Kaplan, A., Fiske, B. R., Savage, P. D., Ades, P. A., Beynnon, B. D., & Toth, M. J. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00830.2016 · Cited by 44 · see citing works
Kitaoka, Y., Nakazato, K., & Ogasawara, R. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00465.2016 · Cited by 43 · see citing works
Deane, C. S., Willis, C. R. G., Phillips, B. E., Atherton, P. J., Harries, L. W., Ames, R. M., Szewczyk, N. J., & Etheridge, T. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12706 · Cited by 40 · see citing works
Molecular Mechanisms of Exercise and Healthspan
Guan, Y., & Yan, Z. (2022) · Cells · doi:10.3390/cells11050872 · Cited by 45 · see citing works
The Role of Mitochondria in Mediation of Skeletal Muscle Repair
Alway, S., Paez, H., & Pitzer, C. R. (2023) · Muscles · doi:10.3390/muscles2020011 · Cited by 43 · see citing works
Ruple, B. A., Godwin, J. S., Mesquita, P. H. C., Osburn, S. C., Sexton, C. L., Smith, M. A., Ogletree, J. C., Goodlett, M. D., Edison, J. L., Ferrando, A. A., et al. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.728683 · Cited by 41 · see citing works
Exercise, mitochondrial dysfunction and inflammasomes in skeletal muscle
Slavin, M. B., Khemraj, P., & Hood, D. A. (2023) · Biomedical Journal · doi:10.1016/j.bj.2023.100636 · Cited by 41 · see citing works
Bishop, D. J., Lee, M. J.-C., & Picard, M. A. (2024) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022724-104836 · Cited by 42 · see citing works
Mthembu, S. X. H., Mazibuko-Mbeje, S. E., Ziqubu, K., Nyawo, T. A., Obonye, N., Nyambuya, T. M., Nkambule, B. B., Silvestri, S., Tiano, L., Muller, C. J. F., et al. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120467 · Cited by 42 · see citing works
Aerobic Adaptations to Resistance Training: The Role of Time under Tension
Mang, Z. A., Ducharme, J. B., Mermier, C. M., Kravitz, L. R., Magalhães, F. D. C., & Amorim, F. T. (2022) · International Journal of Sports Medicine · doi:10.1055/a-1664-8701 · Cited by 40 · see citing works
Khalafi, M., Sakhaei, M. H., Rosenkranz, S. K., & Symonds, M. E. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113888 · Cited by 39 · see citing works
Adaptations of Skeletal Muscle Mitochondria to Obesity, Exercise, and Polyunsaturated Fatty Acids
Chen, P. B., Yang, J. S., & Park, Y. (2018) · Lipids · doi:10.1002/lipd.12037 · Cited by 37 · see citing works
Ruegsegger, G. N., Pataky, M. W., Simha, S., Robinson, M. M., Klaus, K. A., & Nair, K. S. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00405.2023 · Cited by 38 · see citing works
Mitochondrial respiration variability and simulations in human skeletal muscle: The Gene SMART study
Jacques, M., Kuang, J., Bishop, D. J., Yan, X., Alvarez‐Romero, J., Munson, F., GARNHAM, A. P., Papadimitriou, I. D., Voisin, S. A. C., & Eynon, N. (2020) · The FASEB Journal · doi:10.1096/fj.201901997rr · Cited by 35 · see citing works
Gollan, R., Ernst, M., Lieker, E., Caro-Valenzuela, J., Monsef, I., Dresen, A., Roheger, M., Skoetz, N., Kalbe, E., & Folkerts, A. (2022) · Journal of Parkinson s Disease · doi:10.3233/jpd-223252 · Cited by 37 · see citing works
Increased mitochondrial surface area and cristae density in the skeletal muscle of strength athletes
Botella, J., Schytz, C. T., Pehrson, T. F., Hokken, R., Laugesen, S., Aagaard, P., Suetta, C., Christensen, B., Ørtenblad, N., & Nielsen, J. (2023) · The Journal of Physiology · doi:10.1113/jp284394 · Cited by 38 · see citing works
Skeletal muscle thermogenesis enables aquatic life in the smallest marine mammal
Wright, T. J., Davis, R. W., Pearson, H. C., Murray, M. J., & Sheffield‐Moore, M. (2021) · Science · doi:10.1126/science.abf4557 · Cited by 35 · see citing works
Exercise Counteracts the Deleterious Effects of Cancer Cachexia
Tsitkanou, S., Murach, K. A., Washington, T. A., & Greene, N. (2022) · Cancers · doi:10.3390/cancers14102512 · Cited by 33 · see citing works
Effects of Maternal Exercise Modes on Glucose and Lipid Metabolism in Offspring Stem Cells
Jevtovic, F., Zheng, D., Houmard, J. A., Krassovskaia, P. M., Lopez, C. A., Wisseman, B., Steen, D. M., Broskey, N. T., Isler, C. M., DeVente, J., et al. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad059 · Cited by 33 · see citing works
An, J., Su, Z., & Meng, S. (2024) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2024.105530 · Cited by 41 · see citing works
Impact of blood flow‐restricted bodyweight exercise on skeletal muscle adaptations
Jakobsgaard, J. E., Christiansen, M., Sieljacks, P., Wang, J., Groennebaek, T., de Paoli, F., & Vissing, K. (2018) · Clinical Physiology and Functional Imaging · doi:10.1111/cpf.12509 · Cited by 33 · see citing works
Resistance Exercise’s Ability to Reverse Cancer-Induced Anabolic Resistance
Montalvo, R. N., Hardee, J. P., VanderVeen, B. N., & Carson, J. A. (2018) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000159 · Cited by 34 · see citing works
Exercise is mitochondrial medicine for muscle
Oliveira, A. N., & Hood, D. A. (2019) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2019.08.008 · Cited by 34 · see citing works
Holloway, T. M., Morton, R. W., Oikawa, S. Y., McKellar, S. R., Baker, S. K., & Phillips, S. M. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00118.2018 · Cited by 34 · see citing works
Early-stage Alzheimer’s disease: are skeletal muscle and exercise the key?
Brisendine, M. H., & Drake, J. C. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00659.2022 · Cited by 33 · see citing works
Resistance exercise improves cardiac function and mitochondrial efficiency in diabetic rat hearts
Ko, T. H., Marquez, J. C., Kim, H. K., Jeong, S. H., Lee, S., Youm, J. B., Song, I. S., Seo, D. Y., Kim, H. J., Won, D. N., et al. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-2076-x · Cited by 32 · see citing works
Toth, M. J., Voigt, T. B., Tourville, T. W., Prior, S. M., Guigni, B. A., Schlosberg, A. V., Smith, I. B., Forest, T. J., Kaufman, P. A., Wood, M. E., et al. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00203.2020 · Cited by 32 · see citing works
Saeidi, A., Seifi-Skishahr, F., Soltani, M., Daraei, A., Shirvani, H., Laher, I., Hackney, A. C., Johnson, K. E., Basati, G., & Zouhal, H. (2020) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2020.1856142 · Cited by 30 · see citing works
3 D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights Into MFN ‐2‐Mediated Changes
Scudese, E., Marshall, A. G., Vue, Z., Exil, V. J., Rodriguez, B. I., Demirci, M., Vang, L., Lopez, E. G., Neikirk, K., Shao, B., et al. (2025) · Aging Cell · doi:10.1111/acel.70054 · Cited by 32 · see citing works
Vilela, T. C., Effting, P. S., Pedroso, G. S., Farias, H. R., Paganini, L., Sorato, H. R., Nesi, R. T., de Andrade, V. M., & Pinho, R. A. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.02.014 · Cited by 30 · see citing works
Reitzner, S. M., Emanuelsson, E. B., Arif, M., Kaczkowski, B., Kwon, A. T.-J., Mardinoğlu, A., Arner, E., Chapman, M., & Sundberg, C. J. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101857 · Cited by 31 · see citing works
Shi, C., Li, Q., & Zhang, X. (2020) · Pharmacology · doi:10.1159/000505593 · Cited by 30 · see citing works
Jeong, I., Cho, E., Yook, J.-S., Choi, Y., Park, D., Kang, J., Lee, S.-H., Seo, D. Y., Jung, S., & Kwak, H. (2024) · Life · doi:10.3390/life14080962 · Cited by 33 · see citing works
Kuang, J., Saner, N. J., Botella, J., Lee, M. J.-C., Granata, C., Wang, Z., Yan, X., Li, J., Genders, A. J., & Bishop, D. J. (2022) · Acta Physiologica · doi:10.1111/apha.13772 · Cited by 29 · see citing works
Cadegiani, F., & Kater, C. E. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00858 · Cited by 27 · see citing works
Tofas, T., Fatouros, I. G., Draganidis, D., Deli, C. K., Chatzinikolaou, A., Tziortzis, C., Panayiotou, G., Koutedakis, Y., & Jamurtas, A. Z. (2021) · Antioxidants · doi:10.3390/antiox10030409 · Cited by 27 · see citing works
Uemichi, K., Shirai, T., Hanakita, H., & Takemasa, T. (2021) · Physiological Reports · doi:10.14814/phy2.14789 · Cited by 27 · see citing works
Chondronikola, M., Annamalai, P., Chao, T., Porter, C. C., Saraf, M. K., CESANI, F., & Sidossis, L. S. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.76 · Cited by 27 · see citing works
Self-citationDalle, S., & Koppo, K. (2021) · Scientific Reports · doi:10.1038/s41598-021-97859-3 · Cited by 26 · see citing works
- Authors
- PORTER, C., REIDY, P. T., BHATTARAI, N., SIDOSSIS, L. S., & RASMUSSEN, B. B.
- Affiliations
- Shriners Hospitals for Children - Galveston (US)
- The University of Texas Medical Branch at Galveston (US)
- Venue
- Medicine & Science in Sports & Exercise
- Published
- 2015-09
- Volume
- 47
- Issue
- 9
- Pages
- 1922-1931
- ISSN
- 0195-9131 (ISSN-L)
- PMC
- PMC4478283
- OpenAlex
- W2018607292
- Cited by
- 288
- References
- 40
- Citations by year
- 2026: 26 · 2025: 41 · 2024: 36 · 2023: 37 · 2022: 28 · 2021: 28 · 2020: 25 · 2019: 22 · 2018: 23 · 2017: 9 · 2016: 6 · 2015: 7
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Medicine & Science in Sports & Exercise (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000071)
- National Institute on Aging (P30AG024832)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR049877)
- NIH Clinical Center
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- resistance training, skeletal muscle mitochondria, mitochondrial respiration, complex I, succinic acid, mitochondrial biogenesis, electron transfer, muscle strength, lean body mass, exercise adaptation
- MeSH terms
- Adult, Humans, Male, Mitochondria, Muscle, Physical Education and Training, RNA, Messenger, Body Mass Index, Muscle, Skeletal, Cell Respiration, Electron Transport Chain Complex Proteins, Muscle Strength, Resistance Training, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
