Regulation of Skeletal Muscle Glucose Transport and Glucose Metabolism by Exercise Training

Evans, Parker L.; McMillin, Shawna L.; Weyrauch, Luke A.; Witczak, Carol A.

doi:10.3390/nu11102432

Cited by 190Metabolism, Diabetes, and CancerCardiovascular and exercise physiologyMuscle metabolism and nutrition

Regulation of Skeletal Muscle Glucose Transport and Glucose Metabolism by Exercise Training

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Evans, Parker L., McMillin, Shawna L., Weyrauch, Luke A., Witczak, Carol A.·2019·Nutrients

DOI 10.3390/nu11102432PMC PMC6835691

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Abstract

Aerobic exercise training and resistance exercise training are both well-known for their ability to improve human health; especially in individuals with type 2 diabetes. However, there are critical differences between these two main forms of exercise training and the adaptations that they induce in the body that may account for their beneficial effects. This article reviews the literature and highlights key gaps in our current understanding of the effects of aerobic and resistance exercise training on the regulation of systemic glucose homeostasis, skeletal muscle glucose transport and skeletal muscle glucose metabolism.

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Exercise itself, independent of muscle hypertrophy, can potentially reduce fat mass and improve glucose homeostasis by increasing energy expenditure, enhancing insulin sensitivity, and stimulating glucose uptake via contraction-mediated pathways.
“Exercise itself, independent of muscle hypertrophy, can potentially reduce fat mass and improve glucose homeostasis by increasing energy expenditure, enhancing insulin sensitivity, and stimulating glucose uptake via contraction-mediated pathways [25–27].”
From Effects of Skeletal Muscle Hypertrophy on Fat Mass and Glucose Homeostasis in Humans and Animals: A Narrative Review with Systematic Literature Search (2025) · cites this paper as [26]
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Authors: Evans, P. L., McMillin, S. L., Weyrauch, L. A., & Witczak, C. A.
Affiliations: East Carolina University (US)
Corresponding author: Witczak, Carol A.
ORCID: Evans, Parker L.
McMillin, Shawna L.
Weyrauch, Luke A.
Witczak, Carol A.
Venue: Nutrients
Publisher: MDPI AG
Published: 2019-10-12
Volume: 11
Issue: 10
Pages: 2432
ISSN: 2072-6643 (ISSN-L)
DOI: 10.3390/nu11102432
PMC: PMC6835691
OpenAlex: W2979414752
Cited by: 190
References: 214
Citations by year: 2026: 24 · 2025: 24 · 2024: 25 · 2023: 35 · 2022: 35 · 2021: 34 · 2020: 11 · 2019: 2
FWCI: 1.80
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Nutrients (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
The Scholarship East Carolina University's Institutional Repository (East Carolina University) (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institutes of Health (F31 DK119080, R01 DK103562)
American College of Sports Medicine (18-00636)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords: skeletal muscle glucose transport, skeletal muscle glucose metabolism, aerobic exercise training, resistance training, glucose homeostasis, type 2 diabetes, exercise adaptation
MeSH terms: Biological Transport, Glucose, Homeostasis, Humans, Exercise, Muscle, Skeletal

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Regulation of Skeletal Muscle Glucose Transport and Glucose Metabolism by Exercise Training

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