The epidemiology of corticosteroid-induced osteoporosis: a meta-analysis
Open accessAbstract
Studies of oral corticosteroid dose and loss of bone mineral density have reported inconsistent results. In this meta-analysis, we used information from 66 papers on bone density and 23 papers on fractures to examine the effects of oral corticosteroids on bone mineral density and risk of fracture. Strong correlations were found between cumulative dose and loss of bone mineral density and between daily dose and risk of fracture. The risk of fracture was found to increase rapidly after the start of oral corticosteroid therapy (within 3 to 6 months) and decrease after stopping therapy. The risk remained independent of underlying disease, age and gender. We conclude that oral corticosteroid treatment using more than 5 mg (of prednisolone or equivalent) daily leads to a reduction in bone mineral density and a rapid increase in the risk of fracture during the treatment period. Early use of preventive measures against corticosteroid-induced osteoporosis is recommended.
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Sex matching is essential since human male/female differences have been found in total brain volume, gray matter brain volume in specific regions and brain connectivity; sexual dimorphism of the brain has also been found during childhood.
“Moreover, sex matching is essential since human male/female differences have been found in total brain volume (697), gray matter brain volume in specific regions (698) and brain connectivity (699); sexual dimorphism of the brain has also been found during childhood (700)(reviewed in (689)).”
From Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management (2022) · cites this paper as [699]
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- Authors
- Staa, T. P. V., Staa, T. P. V., Staa, T. P. V., Leufkens, H. G. M., & Cooper, C.
- Affiliations
- Utrecht University (NL)
- Southampton General Hospital (GB)
- Venue
- Osteoporosis International
- Published
- 2002-10-01
- Volume
- 13
- Issue
- 10
- Pages
- 777-787
- ISSN
- 0937-941X (ISSN-L)
- 1433-2965
- OpenAlex
- W2124011858
- Cited by
- 1,294
- References
- 4
- Citations by year
- 2026: 34 · 2025: 45 · 2024: 54 · 2023: 47 · 2022: 62 · 2021: 84 · 2020: 54 · 2019: 68 · 2018: 58 · 2017: 72 · 2016: 52 · 2015: 58 · 2014: 51 · 2013: 52 · 2012: 47
- FWCI
- 29.89
- Type
- journal article
- Language
- en
- Open access
- green
- dspace.library.uu.nl
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Osteoporosis International (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- ePrints Soton (University of Southampton) (submittedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
- Keywords
- corticosteroid-induced osteoporosis, oral corticosteroids, bone mineral density, fracture risk, cumulative dose, prednisolone, dose-response relationship, osteoporosis prevention
- MeSH terms
- Aged, Cross-Sectional Studies, Dose-Response Relationship, Drug, Female, Glucocorticoids, Humans, Longitudinal Studies, Male, Middle Aged, Osteoporosis, Prednisolone, Risk Factors, Time Factors, Bone Density, Fractures, Bone
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